Clinical trials: Genital Neoplasm, Female
Cervical Cancer
HPV Testing In Polish POpulation-based Cervical Cancer Screening Program.
The HIPPO PROJECT is a randomized healthcare study nested in the OCCSP in Poland. This project will assess the performance of the new screening test (HR HPV test) before its implementation in Poland.
- Trial name
- HIPPOPROJECT (NCT04111835)
- Testing
- Offering an alternative cervical cancer screening method - hrHPV molecular testing.
- Where
- Poland
- Volunteers
- 33,000 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Infertility
TNF Polymorphism and Implantation Rate
Do TNF-308 and -238 polymorphisms impact the embryo implantation rate after in vitro fertilization (IVF) in women without female infertility factor ?
- Trial name
- NCT02806934
- Testing
- biological and ultrasound test
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cervical Cancer
A Study of Carilizumab Combined With Concurrent Chemoradiotherapy
This is a one-arm phase II clinical study. In patients with stage III-IVA cervical cancer with pelvic lymph nodes > 2cm, positive para-aortic lymph nodes, or lymph node metastases > 2, patients with positive PD-L1 expression (CPS…
- Trial name
- NCT05151549
- Testing
- Camrelizumab, Cisplatin or Carboplatin
- Volunteers
- 46 people
- Sponsor
- Hunan Cancer Hospital
Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer
Multimodal Prehabilitation and Rehabilitation for Men Undergoing Robot-Assisted Radical Prostatectomy
Prostate cancer is the most common cancer in Australian men. Robot-assisted radical prostatectomy (RARP) - surgical removal of the prostate - is a standard treatment, but it frequently causes erectile dysfunction (ED) and urinary…
- Conditions
- Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer, Urinary Incontinence Following Surgical Procedure
- Trial name
- ROBOPREP (NCT07576335)
- Testing
- Tadalafil 5 mg, Pelvic Floor Muscle Training (PFMT), Aerobic Exercise Program
- Where
- 3 sites in Australia
- Volunteers
- 64 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Cancer Cervix
Image Guided Brachytherapy in Locally Advanced Cancer Cervix
This is non comparative prospective interventional study with some areas for observational research to implement based image guided adaptive cervical cancer brachytherapy ( BT ) combined with Intensity Modulated Radiotherapy …
- Trial name
- NCT04767425
- Testing
- Brachytherapy
- Volunteers
- 50 people
- Sponsor
- Fatma Ahmed Abdelfatah Rikabe
Solid Tumors
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-5552 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT04774952
- Testing
- RMC-5552
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Revolution Medicines, Inc.
Endometrial Cancer Recurrent, Endometrial Cancer
A Phase 1 Study to Evaluate OPB-201 in Recurrent Endometrial and Platinum-resistant Ovarian Cancer.
The goal of this clinical trial is to learn if OPB-201 is safe in recurrent endometrial and platinum resistant ovarian cancer participants and also to find the optimal dose of OPB-201.
- Conditions
- Endometrial Cancer Recurrent, Endometrial Cancer, Advanced Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT07664735
- Testing
- OPB-201
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Outpace Bio, Inc.
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Evaluation of Weekly Ixabepilone With or Without Biweekly Bevacizumab
This is a randomized, two-arm, open-label Phase II multicenter study designed to examine the effects of adding bevacizumab to ixabepilone for the treatment of patients who have recurrent or persistent…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- NCT03093155
- Testing
- Ixabepilone, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Yale University
Uterine Cervical Neoplasms, Endometrial Neoplasms
Early Intervention to Prevent Lower Limb Lymphedema of Gynecological Malignancy
This study is a prospective, randomized, controlled clinical trial of a single center in China and plans to enroll 400 patients. 1.
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Lymphedema, Treatment Effectiveness
- Trial name
- NCT05793749
- Testing
- Prophylactic lymphedema treatment
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chongqing University Cancer Hospital
Malignant Ascites
Study of the Trifunctional Antibody Catumaxomab to Treat Recurrent Symptomatic Malignant Ascites
The purpose of this study is to determine whether the investigational drug catumaxomab is a safe and effective treatment for recurrent symptomatic malignant ascites.
- Trial name
- NCT00326885
- Testing
- catumaxomab
- Where
- 18 sites in United States
- Volunteers
- 32 people
- Sponsor
- Neovii Biotech
Hpv
Effectiveness of HPV Vaccine Among Adolescents and Reproductive Women
To assess the effectiveness of HPV vaccine 2 doses or less to prevent HPV high risk infection among adolescents and adults. We conduct the test-negative control study including 12-45 women who interest to do a check-up pap smear.
- Trial name
- NCT06220747
- Where
- 2 sites in Thailand
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Extragonadal Germ Cell Tumor, Ovarian Cancer
Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous bone marrow transplantation may help the body kill more tumor cells.
- Conditions
- Extragonadal Germ Cell Tumor, Ovarian Cancer, Testicular Germ Cell Tumor, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00002943
- Testing
- carboplatin, cyclophosphamide, etoposide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Advanced Solid Tumors, NSCLC
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Based on the overwhelming positive response to this survey and the large number of patients being treated with PD-1/PD-L1 therapy in the UPMC system, the investigators are proposing a trial that will randomize patients who have…
- Conditions
- Advanced Solid Tumors, NSCLC, Bladder Cancer, HNSCC
- Trial name
- NCT04157985
- Testing
- Continue PD-1/PD-L1 Inhibitors treatment, Discontinue PD-1/PD-L1-1 inhibitor
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Dan Zandberg
Cervical Cancer
Prospective Study Assessing Emotional, Sexual and Quality of Life Concerns Of Women Undergoing Removal of the Cervix Versus Removal of the Uterus,Ovaries and Fallopian Tubes For Treatment Of Early Stage Cervical Cancer
The purpose of this study is to will help us understand how two treatments impact women with early stage cervical cancer: a radical hysterectomy, which removes the entire uterus, the ovaries, and fallopian tubes versus a radical…
- Trial name
- NCT00579787
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Cancer, Endometrial Cancer
MR-HIFU for Recurrent Gynaecological Cancer
The primary objective of this pilot study is to determine whether or not it is feasible to use MRgHIFU to treat symptomatic (pain, bleeding) recurrent pelvic malignancy with an acceptable safety profile when conventional…
- Conditions
- Cervical Cancer, Endometrial Cancer, Uterine Cancer, Ovarian Cancer
- Trial name
- HIFU-Gynae (NCT02714621)
- Testing
- Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cervical Cancer, Precancerous/Nonmalignant Condition
UMCC 9609 Tretinoin in Preventing Cancer of the Cervix in Patients With Cervical Neoplasia
RATIONALE: Tretinoin may help cervical neoplasia cells develop into normal cervical cells. It is not yet known whether tretinoin is more effective than a placebo in preventing cervical cancer in patients with cervical neoplasia.
- Trial name
- IRB 1996-0189 (NCT00003598)
- Testing
- tretinoin
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Michigan Rogel Cancer Center
Cervical Cancer
Health Care Decisions for Female Adolescents: The Role of Mothers and Daughters in Decision Making
Preventing cervical cancer is a public health concern. Since 2006 a quadrivalent vaccine for young women nine to twenty six years of age has been available to protect against the human papillomavirus (HPV) and to prevent some…
- Trial name
- NCT00807898
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Ovarian Cancer, Fallopian Tube Cancer
Feasibility of Interval Debulking Surgery by Laparoscopy for Peritoneal Carcinosis in Chemosensitive Patients
This prospective nonrandomized multicenter phase II study, will evaluate the possibility of performing a laparoscopic interval debulking after a minimum of 3 cycles of chemotherapy in highly chemo-sensitive patients with advanced…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cavity Cancer
- Trial name
- CILOVE (NCT01905163)
- Testing
- Tumor Debulking Surgery by laparoscopy
- Where
- 10 sites in France
- Volunteers
- 47 people
- Sponsor
- Centre Jean Perrin
Gynecological Cancer, Dyspareunia
Physiotherapy Treatment in Women With Dyspareunia Following Gynecological Cancer: a Pilot Study
Gynecological cancers represent more than half of female cancers. It has been clearly established that cancer survivors suffer from important health issues such as pain during sexual intercourse (dyspareunia) and sexual…
- Trial name
- NCT03935698
- Testing
- Physiotherapy
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Université de Sherbrooke
Spina Bifida, Urothelial Neoplasm
Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
Different clinical conditions can require urinary bladder augmentation or replacement. Tissue engineered bladder has been clinically evaluated but is not recommended due to diverse side effects.
- Conditions
- Spina Bifida, Urothelial Neoplasm, Bladder, Neurogenic, Bladder Exstrophy
- Trial name
- IMOPU (NCT03698721)
- Testing
- Transurethral Resection of Prostate
- Volunteers
- 365 people
- Sponsor
- Central Hospital, Nancy, France
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