Clinical trials: Genital Neoplasm
Cervical Intraepithelial Neoplasia
Feasibility of the Management of Severe Cervical Dysplasia in a Single Visit
1. Implement a single-visit program (SVP) for cervix cancer prevention in clinics serving a multi-ethnic population of women; 2.
- Trial name
- NCT00237562
- Testing
- Large loop electrosurgical excision
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Prostate Cancer, Urinary Incontinence
Pre-Operative Nurse-Led Education With Direct Physiotherapy Referral to Reduce Post-Prostatectomy Incontinence
Urinary incontinence is a common complication following radical prostatectomy and can significantly impact quality of life. Pelvic floor physiotherapy is recommended to reduce post-operative incontinence; however, referral…
- Conditions
- Prostate Cancer, Urinary Incontinence, Postoperative Complications, Radical Prostatectomy
- Trial name
- PRO-ACT (NCT07426861)
- Testing
- Standard Pre-Operative Education and Physiotherapy Recommendation, Pre-Operative Nurse-Led Education with Direct Physiotherapy Referral
- Where
- Ireland
- Volunteers
- 80 people
- Sponsor
- Royal College of Surgeons, Ireland
Prostate Cancer
Preoperative Semaglutide Prior to Radical Prostatectomy
In this exploratory, single-arm, nonrandomized trial, the impact of the preoperative utilization of the glucagon-like peptide-1 (GLP-1) receptor agonist (RA) semaglutide prior to radical prostatectomy in participants with…
- Trial name
- NCT07727473
- Testing
- Semaglutide 2.4 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Banner Health
Polycystic Ovary Syndrome
Combined Chromium With Letrozole Versus Letrozole Only in Induction of Ovulation in Patients With Polycystic Ovary Syndrome
Combined letrozole with chromium versus letrozole only in induction of ovulation in polycystic ovary syndrome
- Trial name
- NCT05765305
- Testing
- Letrozole with chromium
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Prostatic Neoplasm
Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate
In current clinical practice, an acceptable standard treatment for locally advanced prostate cancer is radiation therapy in combination with hormone therapy (called Treatment B or Group B in this study).
- Trial name
- PREMIUM (NCT01996696)
- Testing
- Metformin
- Where
- 3 sites in Canada
- Volunteers
- 83 people
- Sponsor
- AHS Cancer Control Alberta
Uterine Neoplasms, Endometrial Neoplasms
Colony-Stimulating Factor-1 (CSF-1) and Other Cytokines in Human Endometrial Carcinogenesis
The purposes of this study are the following: 1. To further characterize and quantify both CSF-1 and colony-stimulating factor-1 receptor (CSF-1R) expression from additional tumor specimens, specifically, tumors of high grade and…
- Trial name
- NCT00250770
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Prostate Cancer
Prognostic Value of SPECT-CT Quantitative Indices for the Response Assessment of Bone Metastatic Prostate Carcinoma
Prognostic interest of bone scintigraphy in bone metastatic prostate carcinoma (BMPC) has been shown. Recent technological advances allow to perform quantitative bone SPECT-CT in routine practice.
- Trial name
- INTEVOPROSTATE (NCT03382522)
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Brest
Prostate Cancer
Targeted And Perilesional Or Systematic Biopsy In Prostate Cancer
Magnetic Resonance Imaging (MRI) improves the detection of clinically significant prostate cancer (PCa) by guiding biopsies of MRI-visible lesions (targeted biopsies) in patients suspected with having PCa.
- Trial name
- TARGET (NCT07296042)
- Testing
- Prostate biopsy
- Where
- 5 sites in France
- Volunteers
- 456 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Gastric Cancer, Renal Cell Carcinoma
A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
The purpose of this study is to test the safety and tolerability of HFB200301 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study.
- Conditions
- Gastric Cancer, Renal Cell Carcinoma, Melanoma, Sarcoma
- Trial name
- NCT05238883
- Testing
- HFB200301, Tislelizumab
- Where
- 10 sites in United States, Spain
- Volunteers
- 72 people
- Sponsor
- HiFiBiO Therapeutics
Prostate Cancer, Prostatic Neoplasms
Predictive Factors for Response to Lutetium-177 PSMA Radioligand Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer
The goal of this observational study is to learn which factors can predict how well lutetium-177 PSMA therapy works in people with metastatic castration-resistant prostate cancer (mCRPC).
- Conditions
- Prostate Cancer, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Neoplasm Metastases
- Trial name
- NCT07863986
- Testing
- [177Lu]Lu-PSMA-617 (Pluvicto, Novartis), 68Ga-PSMA-11 PET/CT, Post-therapy 177Lu-PSMA SPECT/CT dosimetry
- Where
- Lithuania
- Volunteers
- 70 people
- Sponsor
- Lithuanian University of Health Sciences
Uterine Cervical Neoplasms, Cancer of Cervix
Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors
This is a phase II trial of combination therapy of cadonilimab(Bispecific Anti-PD-1/CTLA-4 Antibody) plus nab-Paclitaxel in patients with recurrent or metastatic cervical cancer that had failed PD-1/PD-L1 blockade therapy.
- Conditions
- Uterine Cervical Neoplasms, Cancer of Cervix, Cervical Cancer, Cervical Neoplasms
- Trial name
- NCT05824494
- Testing
- Cadonilimab, Nab paclitaxel
- Volunteers
- 58 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Precancerous/Nonmalignant Condition, Prostate Cancer
Vitamin E, Selenium, and Soy Protein in Preventing Cancer in Patients With High-Grade Prostate Neoplasia
RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development or recurrence of cancer. Vitamin E, selenium, and soy protein may be effective in preventing the development of prostate…
- Trial name
- NCT00064194
- Testing
- selenium, soy protein isolate, vitamin E
- Where
- 3 sites in Canada
- Volunteers
- 310 people
- Sponsor
- NCIC Clinical Trials Group
Ovarian Cancer
Women's Activity and Lifestyle Study in Connecticut
Despite an increase in longevity, surviving ovarian cancer often brings an array of unpleasant side effects and compromises in QOL.
- Trial name
- WALC (NCT02107066)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Yale University
Intraepithelial Neoplasia, Cervical
Comparison of Treatment of Cervical Intraepithelial Lesions With Imiquimod or LLETZ
Purpose: There are limited data on the success of conservative treatment of high-grade cervical squamous intraepithelial lesions (HSIL) with imiquimod directly compared to standard of treatment with LLETZ.
- Trial name
- NCT04859361
- Testing
- Aldara 5% Topical Cream, LLETZ
- Where
- Slovenia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Prostate Cancer, Castrate Sensitive Prostate Cancer
Focal Radiation With Pulsed Systemic Therapy of Abiraterone, Androgen Deprivation Therapy (ADT), Lynparza Towards Castration Sensitive Oligometastatic Prostate Cancer (FAALCON)
The purpose of this study is to assess the safety and effectiveness of radiation therapy with hormone therapy (ADT) and chemotherapy as an investigational study treatment for prostate cancer.
- Conditions
- Prostate Cancer, Castrate Sensitive Prostate Cancer, Oligometastatic Disease
- Trial name
- NCT04748042
- Testing
- Abiraterone, Prednisone, External Beam Radiotherapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Michigan Rogel Cancer Center
Endometrial Cancer
Carboplatin, Paclitaxel With or Without Avelumab in Advanced or Recurrent Endometrial Cancer
This study aims to evaluate the safety and activity of the Avelumab in combination with Carboplatin-Paclitaxel in advanced or recurrent endometrial cancer
- Trial name
- MITO END-3 (NCT03503786)
- Testing
- Carboplatin, Paclitaxel, Avelumab
- Where
- 11 sites in Italy
- Volunteers
- 125 people
- Sponsor
- National Cancer Institute, Naples
Endometrial Cancer
OSNA Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer
Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the…
- Trial name
- SENT-OSNA (NCT06935305)
- Testing
- OSNA, Ultrastaging
- Where
- Italy
- Volunteers
- 1,922 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prostatic Neoplasms, Genital Neoplasms, Male
Protection of Rectum From High Radiation Doses Using a Spacer
The purpose of this study is to evaluate the usefulness of diluted and non-diluted DuraSeal product as a spacer between prostate and rectum in prostate cancer low-dose brachytherapy.
- Conditions
- Prostatic Neoplasms, Genital Neoplasms, Male, Urogenital Neoplasms, Neoplasms by Site
- Trial name
- NCT01918605
- Testing
- Diluted spacer, Non-diluted spacer
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- University of Oulu
Prostate Cancer
Biopsy Collection for Men Undergoing Brachytherapy for Prostate Cancer
The primary goal of this tissue collection protocol is to establish a framework for the acquisition and banking of biospecimen collected from men undergoing brachytherapy.
- Trial name
- NCT04243473
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
68Ga-PSMA PET/CT in Prostate Cancer
The objectives of this study are to replicate the safety and efficacy of 68Ga-PSMA PET/CT and as a diagnostic and decision making tool in the management prostate cancer patients.The primary endpoints of the study are the…
- Trial name
- NCT03001869
- Testing
- 68Ga-HBED-CC-PSMA PET/CT
- Where
- Canada
- Volunteers
- 540 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
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