Clinical trials: Genital Neoplasm
Precancerous/Nonmalignant Condition, Prostate Cancer
S9917, Selenium in Preventing Cancer in Patients With Neoplasia of the Prostate
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. The use of selenium may be an effective way to prevent prostate cancer in patients who have neoplasia of the prostate.
- Trial name
- NCT00030901
- Testing
- L-selenomethionine
- Volunteers
- 619 people
- Sponsor
- SWOG Cancer Research Network
Lymphedema of Leg, Cancer of Cervix
High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs
The aim of the study is to explore the feasibility and safety of High Intensity Interval Training on a stationary bike for patients with lymphedema in the lower limbs and the role of compression garments during exercise.
- Conditions
- Lymphedema of Leg, Cancer of Cervix, Cancer, Ovarian, Cancer, Endometrial
- Trial name
- NCT03653819
- Testing
- First exercise session + compression, First exercise session - compression
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Herlev and Gentofte Hospital
Gynecological Malignancies, Genital Neoplasms, Female
Treatment for Patients With Gynecological Malignancies Who Suffer From Anemia Due to Chemotherapy
The purpose of this study is to validate a Patient Satisfaction Questionnaire for Anemia Treatment (PSQ-AT) in gynecological cancer patients treated with darbepoetin alfa or recombinant human erythropoietin (rHuEPO) for anemia…
- Conditions
- Gynecological Malignancies, Genital Neoplasms, Female, Anemia
- Trial name
- NCT00121030
- Testing
- darbepoetin alfa, recombinant human erythropoietin (rHuEPO)
- Sponsor
- Amgen
Cervix Cancer, HIV Infections
Clinic vs Clinic+Community Outreach HPV Self-Collection to Increase Cervical Screening in Women With HIV
This Clinical Trials Network for Human Immunodeficiency Virus (HIV)-Associated Cervical Cancer Screening and Treatment Optimization (CASCADE) C3001-A trial aims to assess how the introduction of a…
- Conditions
- Cervix Cancer, HIV Infections, HPV Infection
- Trial name
- CASCADE3001A (NCT07428330)
- Testing
- Model 1- Screening in Clinic Only, Model 2 - Screening in Clinic and Community
- Where
- Uganda
- Volunteers
- 7,597 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Carcinoma
An Investigational Scan (MRI With Dixon Based Sequences) in Detecting Prostate Cancer
This trial studies the use of magnetic resonance imaging (MRI) with Dixon based imaging sequences in detecting prostate cancer. MRI uses radio waves and a powerful magnet linked to a computer to create detailed pictures of areas…
- Trial name
- NCT05047965
- Testing
- Dixon MRI, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancers
FACBC Positron Emission Tomography/Computed Tomography(PET/CT) Used in the Diagnosis of Primary Prostate Cancer
The purpose of this research project is to test if a compound (chemical substance) has a natural tendency to go to prostate cancer. This compound has a small amount of radioactivity attached to it and is called a radiotracer.
- Trial name
- NCT00917865
- Testing
- anti [18F]FACBC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David M. Schuster, MD
Ovarian Cancer
Olaparib Monotherapy and Olaparib + Pembrolizumab Combination Therapy for Ovarian Cancer
To evaluate the efficacy and safety of preoperative olaparib monotherapy and preoperative olaparib plus pembrolizumab combination therapy in patients with untreated stage III, IV high-grade serous or Grade 3 endometrioid ovarian…
- Trial name
- OLAPem (NCT04417192)
- Testing
- Olaparib, Pembrolizumab
- Where
- 3 sites in Japan
- Volunteers
- 30 people
- Sponsor
- National Cancer Center Hospital East
Papillomavirus Infections, Pregnancy Complications
Human Papillomavirus (HPV) Infection in Pregnancy
The purpose of this study is to determine if maternal infection with human papillomavirus (HPV) is associated with pregnancy complications including spontaneous preterm delivery (sPTD), severe preeclampsia (PE), and poor fetal…
- Trial name
- NCT00194311
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer Survivor, Sexual Dysfunction
Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors
RATIONALE: The hormone testosterone may improve the libido (sex drive) in women. It is not yet known whether testosterone is effective in improving libido in female cancer survivors.
- Conditions
- Cancer Survivor, Sexual Dysfunction, Sexuality and Reproductive Issues, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00075855
- Testing
- therapeutic testosterone
- Where
- 16 sites in United States
- Volunteers
- 150 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Ovarian Cancer, Primary Peritoneal Cavity Cancer
Monoclonal Antibody Therapy in Treating Patients With Ovarian Cancer or Primary Peritoneal Cancer in Remission Following Surgery and Chemotherapy
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00004115
- Testing
- yttrium Y 90 monoclonal antibody HMFG1
- Where
- United Kingdom
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer
Comparison of PET With 68GA-PSMA-11 and 18F-Fluorocholine for Recurrence in Men With Prostate Cancer
As choline transport and phosphorylation are upregulated in most cancers, including prostate cancer, positron emission tomography (PET) with choline tracers has found widespread use to detect recurrent disease.
- Trial name
- TEPGALCHOL (NCT03623425)
- Testing
- 68Ga-PSMA-11 PET, 18F-FCH PET
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Epithelial Ovarian Cancer
Surgical Trial Comparing LIGASURE Assisted Recto-Sigmoid Resection and Omentectomy Compared to Stand
The objective of this prospective randomized surgical trial is to evaluate whether the use of the LIGASURE surgical device during omentectomy and/or recto-sigmoid resection for women with ovarian cancer will reduce the surgical…
- Trial name
- NCT01549925
- Testing
- Standard Surgical resection, LIGASURE
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Endometrial Cancer
Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer
RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence.
- Trial name
- NCT00002976
- Testing
- conjugated estrogens
- Where
- 149 sites in United States
- Volunteers
- 2,108 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer, Endometrial Cancer
Pelvic Floor Muscle Training in Treating Urinary Incontinence in Gynecologic Cancer Survivors
This randomized pilot clinical trial studies pelvic floor muscle training in treating urinary incontinence in gynecologic cancer survivors.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Epithelial Cancer, Ovarian Germ Cell Tumor
- Trial name
- NCT01806350
- Testing
- questionnaire administration, standard follow-up care, educational intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New Mexico Cancer Research Alliance
Trophoblastic Neoplasms, Uterine Neoplasms
A Trial for Patients With Gestational Trophoblastic Disease
This phase II study is evaluating the activity of Pemetrexed in patients diagnosed with low risk Gestational Trophoblastic Tumor (GTT) that have failed prior treatment.
- Conditions
- Trophoblastic Neoplasms, Uterine Neoplasms, Hydatidiform Mole, Choriocarcinoma
- Trial name
- NCT00190918
- Testing
- Pemetrexed
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Eli Lilly and Company
Fallopian Tube Cancer, Ovarian Cancer
Mifepristone in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
RATIONALE: Progesterone can cause the growth of ovarian epithelial cancer , primary peritoneal cancer, or fallopian tube cancer.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00459290
- Testing
- mifepristone
- Where
- 22 sites in United States
- Volunteers
- 24 people
- Sponsor
- Gynecologic Oncology Group
Prostate Cancer
Positron Emission Tomography and Magnetic Resonance Imaging for Prostate Cancer
Background: Prostate cancers are difficult to see on most imaging studies such as X-rays, computed tomography (CT) scans, conventional magnetic resonance imaging (MRI) scans and conventional positron emission tomography (PET)…
- Trial name
- NCT00924313
- Testing
- (C-11 Acetate)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
NSCLC, Prostate Cancer
Clinical Trial of TB511 in Advanced Solid Tumors
1. Study population [TB511 Monotherapy Cohort for Phase 1 and Phase 2a Clinical Trial] Patients with advanced solid tumors who are either refractory or intolerant to standard of care (SoC).
- Conditions
- NSCLC, Prostate Cancer, Colorectal Cancer, Hepatocellular Carcinoma
- Trial name
- NCT06400160
- Testing
- TB511, Keytruda
- Volunteers
- 12 people
- Sponsor
- Twinpig Biolab, Inc.
Prostate Cancer
R-Flurbiprofen in Treating Patients With Localized Prostate Cancer at Risk of Recurrence
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. R-flurbiprofen may be effective in delaying the recurrence of localized prostate cancer.
- Trial name
- NCT00045123
- Testing
- tarenflurbil, adjuvant therapy
- Where
- 58 sites in United States
- Sponsor
- Myrexis Inc.
Ovarian Neoplasms, Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
Ovarian cancer is a heterogeneous disease, characterized by complex molecular and genetic changes. The high expression of vascular endothelial growth factor (VEGF) receptor, programmed death receptor ligands 1 (PD-L1) expression…
- Trial name
- FIRST (NCT03602859)
- Testing
- Niraparib, Dostarlimab (TSR-042), Standard of care
- Where
- 182 sites in United States, Belarus and 17 more
- Volunteers
- 1,400 people
- Sponsor
- Tesaro, Inc.
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