Clinical trials: Genital Neoplasm
Localized Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8
Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients
This early phase I is to find out how common vitamin D insufficiency is among African American patients with a history of prostate cancer that has not spread to other parts of the body (localized) or has spread to other places in…
- Conditions
- Localized Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8, Locally Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma
- Trial name
- NCT05045066
- Testing
- Cholecalciferol, Quality-of-Life Assessment, Biospecimen Collection
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Mayo Clinic
Neoplasms
Safety and Tolerability Study of AZD2171 in Combination With AZD0530 in Patients With Advanced Solid Tumours
The purpose of the study is to determine if the maximum tolerated doses of AZD2171, in combination with AZD0530, in treating patients with advanced solid tumours are safe, tolerable and efficacious.
- Trial name
- NCT00475956
- Testing
- AZD2171, AZD0530
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Urinary Tract Infection, Prostatitis
FOsfomycin for Male Urinary Tract Infection
Male urinary tract infections (MUTI) are often less recognised compared to those in women. French clinical guidelines practices recommend the use of antibiotics called fluoroquinolones, which are highly effective in treating…
- Conditions
- Urinary Tract Infection, Prostatitis, Cystitis
- Trial name
- FOMUTI (NCT06822751)
- Testing
- Fosfomycun-trometamol
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Rouen
Endometrial Cancer, Stress Urinary Incontinence
Cancer of the Uterus and Treatment of Stress Urinary Incontinence
Concurrent treatment of endometrial cancer and SUI may improve QOL, emotional and physical health and decrease costs for both patients and the health care system.
- Trial name
- CUTI (NCT02667431)
- Where
- United States
- Volunteers
- 556 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Prostate Cancer
Optimized 2D-RT for Prostate Cancer
Prostate cancer (CAP) is one of the most common malignancies in men, both in Western countries and developing countries. Radiation therapy (RT) is an important therapeutic option.
- Trial name
- NCT03339531
- Testing
- 2D radiotherapy
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometrial Cancer, Cervical Cancer
Implementation of Surgical Safety and Intraoperative Metastasis Identification Through Deep Learning: Multicentric Video Collection for Minimally Invasive Sentinel Lymph Node Dissection in Uterine Malignancies
The loco-regional metastatic or non-metastatic status of lymph nodes (LN) is critical for the therapeutic management of most cancer patients.
- Conditions
- Endometrial Cancer, Cervical Cancer, Deep Learning, Artificial Intelligence
- Trial name
- LYSE (NCT06619002)
- Testing
- Sentinel lymph node sampling
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neoplasms
A Study of DOXIL/CAELYX in Patients With Advanced or Refractory Solid Malignancies Including Patients With Ovarian Cancer
The purpose of this study is to support the qualification of a replacement manufacturing site for DOXIL/CAELYX.
- Trial name
- NCT02081495
- Testing
- DOXIL/CAELYX reference product (Treatment A), DOXIL/CAELYX test product (Treatment B)
- Where
- 6 sites in United States, Belgium and 2 more
- Volunteers
- 35 people
- Sponsor
- Janssen Research & Development, LLC
Prostate Cancer
EPI-7386 in Combination with Enzalutamide Compared with Enzalutamide Alone in Subjects with MCRPC
This is a Phase 1/2 study of EPI-7386 orally administered in combination with enzalutamide in subjects with mCRPC. Phase 1 of the study will be a single-arm dose escalation study of EPI-7386 in combination with a fixed dose of…
- Trial name
- NCT05075577
- Testing
- Enzalutamide, EPI-7386 with Enzalutamide
- Where
- 24 sites in United States, Australia and 1 more
- Volunteers
- 77 people
- Sponsor
- ESSA Pharmaceuticals
Prostate Cancer
Cisplatin in Castration Resistant Prostate Cancer
It is hypothesized that treatment with cisplatin will reverse emerging refractoriness to enzalutimide in patients with CRPC by affecting AR function.
- Trial name
- NCT03275857
- Testing
- Cisplatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Prostate Cancer
Salvage Moderate Hypofractionated Versus Ultrahypofractionated Radiotherapy for Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer
This study is the first prospective, randomized phase III clinical trial designed to evaluate whether ultrahypofractionated radiotherapy is non-inferior to conventionally moderately hypofractionated radiotherapy in terms of…
- Trial name
- NCT07500701
- Testing
- Moderate hypofractionated radiotherapy (Moderate-hypoRT), Ultra-hypofractionated radiotherapy (Ultra-hypoRT)
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Samsung Medical Center
Cervical Cancer
Feasibility - Beta Adrenergic Blockade (BB) in Cervical Cancer (CX)
The goal of this clinical research study is to learn how many patients with advanced, recurrent, incurable cervical cancer will complete questionnaires about symptoms, any anxiety, depression, and/or pain, and the quality of…
- Trial name
- NCT01902966
- Testing
- Propranolol, Diary, Relaxation Audio Recording
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Cardiovascular Diseases, Breast Cancer
RCT of Strategies to Augment Physical Activity in Black and Hispanic Breast and Prostate Cancer Survivors (ALLSTAR)
This is a two-arm, randomized, controlled trial to evaluate the effectiveness of using a behaviorally designed gamification intervention with social support compared to an attention control group to increase physical activity…
- Conditions
- Cardiovascular Diseases, Breast Cancer, Prostate Cancer, Physical Inactivity
- Trial name
- ALLSTAR (NCT05176756)
- Testing
- Gamification and Social Support, Attention control
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Adult Solid Neoplasm, Recurrent Ovarian Carcinoma
Eribulin Mesylate and Gemcitabine Hydrochloride in Treating Patients With Metastatic Solid Tumors or Solid Tumors That Cannot be Removed by Surgery
This phase I trial is studying the side effects and best dose of eribulin mesylate and gemcitabine hydrochloride in treating patients with metastatic or unresectable solid tumors.
- Conditions
- Adult Solid Neoplasm, Recurrent Ovarian Carcinoma, Recurrent Uterine Corpus Carcinoma, Stage III Ovarian Cancer AJCC v6 and v7
- Trial name
- NCT00410553
- Testing
- Eribulin Mesylate, Gemcitabine Hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
High-Dose Stereotactic Radiation for Prostate Cancer
This clinical trial studies high-dose stereotactic body radiation therapy (SBRT) in treating patients with low-, intermediate-, or high-risk localized prostate cancer.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer
- Trial name
- NCT01664130
- Testing
- stereotactic body radiation therapy, quality-of-life assessment, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Case Comprehensive Cancer Center
Ovarian Cancer
A Study With Intraperitoneal Cisplatin and Doxorubicin in Recurrent Ovarian Cancer and Peritoneal Carcinomatosis
Fifteen women with recurrent ovarian cancer will be treated by an intraperitoneal chemotherapy with cisplatin and doxorubicin in three escalating dosage schedules.
- Trial name
- NCT02475772
- Testing
- Cisplatin and doxorubicin
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Clemens Tempfer
Cervical Precancer
Development, Field Testing and Evaluation of the Efficacy of a Hand-held, Portable and Affordable Thermo-coagulator to Prevent Cervical Cancer in Low- and Middle-income Countries
This project develops, tests and produces a lightweight, cordless, battery driven and rechargeable hand-held device for treating cervical precancer (Liger Thermal Coagulator).
- Trial name
- DELTA (NCT02956239)
- Testing
- Thermocoagulation (device), Cryotherapy (device), LEEP (device)
- Where
- Zambia
- Volunteers
- 3,124 people
- Sponsor
- International Agency for Research on Cancer
Prostatic Neoplasms
18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer
PyL, also known as [18F]DCFPyL, is a second-generation fluorinated prostate-specific membrane antigen (PSMA) targeted PET imaging agent.
- Trial name
- NCT03824275
- Testing
- 18F- DCFPyL PET/CT
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Columbia University
Ovarian Cancer, Caregiver Burden
Multidimensional Burden of Platinum Resistant Ovarian Cancer (PROC) on Patients and Caregivers in Canada
Filling the gap in Canadian evidence on the burden of PROC on QoL is essential. It will help better understand the impact of PROC on multiple aspects of the lives of patients and their caregivers and the real-life hurdles faced…
- Conditions
- Ovarian Cancer, Caregiver Burden, Patient Burden
- Trial name
- NCT07035067
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Metastatic Castration-Resistant Prostatic Cancer
A Clinical Trial Evaluating the Safety of TD001 In Patients With PSMA-Expressing Metastatic Prostate Cancer
This study will evaluate the safety, tolerability, drug levels (pharmacokinetics) and preliminary antitumor activity of TD001, an antibody-drug conjugate (ADC) targeting prostate-specific membrane antigen (PSMA), in men with…
- Trial name
- NCT07258407
- Testing
- TD001
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 180 people
- Sponsor
- T.O.A.D. Oncology SA
Ovarian Cancer, Cervical Cancer
Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates.
The prevalence of anemia in gynecologic oncology new patients has been seen in previous studies to be as high as 35-59%. this population includes women with several types of gynecologic malignancies.
- Conditions
- Ovarian Cancer, Cervical Cancer, Uterine Cancer, Anemia
- Trial name
- NCT01953107
- Testing
- Oral Ferrous Fumarate
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
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