Clinical trials: Genital Neoplasm
Progesterone Receptor Positive Tumor: Max 1 Line of Prior Chemotherapy, no Prior Hormone Therapy
Phase 1-2 Study of Onapristone in Patients With Progesterone Receptor Expressing Cancers
This is a multi-center, open-label, randomized, parallel group two-stage phase 1 study with a phase 2 expansion component in pts with recurrent or metastatic APRpos uterine endometrioid adenocarcinoma.
- Trial name
- NCT02052128
- Testing
- onapristone
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Arno Therapeutics
Prostate Cancer, Hormone Refractory Prostate Cancer
Satraplatin in Hormone Refractory Prostate Cancer Patients Previously Treated With One Cytotoxic Chemotherapy Regimen
PURPOSE: The SPARC trial is designed to compare the combination of the investigational oral cytotoxic drug, satraplatin, and prednisone, versus prednisone alone as second line chemotherapy in patients with hormone-refractory…
- Trial name
- NCT00069745
- Testing
- Satraplatin, Prednisone
- Where
- 211 sites in United States, Argentina and 13 more
- Sponsor
- Agennix
Prostate Cancer
Phase I Trial of 225Ac-J591 in Patients With mCRPC
This is an open-label, single-center Phase I dose escalation study designed to determine the dose-limiting toxicity (DLT) and the maximum tolerated dose (MTD) of 225Ac-J591 in a single dose regimen.
- Trial name
- NCT03276572
- Testing
- 225Ac-J591
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Weill Medical College of Cornell University
Prostate Cancer
Spanish Urological Association Registry of Patients on Active Surveillance
Description: Multicentre observational study, not randomized. Ambispective character (retro and prospective). Opened to any member of the Asociación Española de Urología (AEU), public and private medicine.
- Trial name
- NCT02865330
- Testing
- Registry
- Where
- Spain
- Volunteers
- 946 people
- Sponsor
- Fundación Instituto Valenciano de Oncología
Recurrent Cervical Carcinoma, Recurrent Uterine Corpus Carcinoma
Patient, Physician, and Nurse Factors Associated With Entry Onto Clinical Trials and Finishing Treatment in Patients With Primary or Recurrent Uterine, Endometrial, or Cervical Cancer
This clinical trial is studying patient, physician, and nurse factors associated with entry onto clinical trials and finishing treatment in patients with primary or recurrent uterine, endometrial, or cervical cancer.
- Conditions
- Recurrent Cervical Carcinoma, Recurrent Uterine Corpus Carcinoma, Recurrent Uterine Corpus Sarcoma, Stage I Uterine Corpus Cancer
- Trial name
- NCT01098630
- Testing
- Medical Chart Review, Questionnaire Administration
- Where
- 167 sites in United States
- Volunteers
- 778 people
- Sponsor
- Gynecologic Oncology Group
Uterine Fibroid, Pregnancy Complications
Pregnancy Outcomes Following Myomectomy
The most prevalent genital pathology, uterine fibroids have a detrimental impact on the health of women. Fibroid symptoms are typically more impactful on females and frequently require uterine excision.
- Conditions
- Uterine Fibroid, Pregnancy Complications, Reproductive Issues, Reproductive Sterility
- Trial name
- NCT06474065
- Testing
- Myomectomy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Breast Cancer, Prostate Cancer
A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer
The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT).
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT07225309
- Testing
- Meaning-Centered Psychotherapy for Latinos /MCP-L
- Where
- 2 sites in United States, Mexico
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostatic Cancer
Autologous Dendritic Cell Therapy for Hormone-Refractory Metastatic Prostate Cancer
This is an open label, Phase I/IIa trial of immunotherapy with CreaVax-PC as treatment in men with hormone-Refractory Metastatic Prostate Cancer.
- Trial name
- NCT01171729
- Testing
- Autologous dendritic cell
- Where
- 2 sites in South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Prostate Cancer
Flu/TBI in Treating Patients Not Responding to Previous Hormone Therapy
RATIONALE: Giving low doses of chemotherapy, such as fludarabine, and radiation therapy before a donor stem cell transplant helps stop the growth of cancer cells.
- Trial name
- NCT00242931
- Testing
- Nonmyeloablative stem cell conditioning regimen
- Sponsor
- OHSU Knight Cancer Institute
Recurrent Ovarian Cancer
Safety and Efficacy Study of Nuc-1031 and Carboplatin Combination to Treat Recurrent Ovarian Cancer
A first in human experimental treatment in which an experimental medicine,Nuc-1031, is used in combination with a standard cancer medicine, carboplatin, to treat ovarian cancer which reappear after standard cancer treatment.
- Trial name
- ProGem2 (NCT02303912)
- Testing
- Nuc-1031 and Carboplatin
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College Healthcare NHS Trust
Prostate Cancer
Vaccine Therapy Plus QS21 in Treating Patients With Progressive Prostate Cancer
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of vaccine therapy given with QS21 in treating patients who have progressive prostate cancer.
- Trial name
- NCT00003819
- Testing
- QS21, TF(c)-KLH conjugate vaccine, Thomsen-Friedenreich antigen
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Innovative Planning and Guidance System for Prostate Focal Brachytherapy
A key feature of low-dose brachytherapy is that irradiation affects only a local area around the inserted radiation sources. The exposure of healthy tissues around these sources is then reduced.
- Trial name
- FOCUS (NCT03160365)
- Testing
- ACQUISITION OF IMAGES
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Brest
Bladder Cancer, Prostate Cancer
Occupational Situation and Return to Work of Urological Patients
This study will examine the work status of all adult patients admitted over a 6-month period to the University Hospital in Kraków, Poland, for treatment of urological diseases.
- Conditions
- Bladder Cancer, Prostate Cancer, Renal Cancer, Urinary Stones
- Trial name
- OCCURORTW (NCT07088536)
- Testing
- Occupational Status Survey and Telephone Follow-up and Quality-of-Life Assessment in a subset of patients
- Where
- Poland
- Volunteers
- 2,000 people
- Sponsor
- Jagiellonian University
Ovarian Carcinoma, Ovarian Cancer
Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal Masses
This study is performed to compare the diagnostic performance and cost-effectiveness of different diagnostic methods for differentiating benign from malignant adnexal (ovary or Fallopian tube) masses: the Risk of Malignancy Index…
- Conditions
- Ovarian Carcinoma, Ovarian Cancer, Ovarian Mass, Ovarian Cyst
- Trial name
- SUBSONiC (NCT02218502)
- Testing
- Ultrasound by general gynaecologist, Ultrasound by an expert ultrasonographist, DW-MRI
- Where
- 5 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Obesity, Colorectal Cancer
Prevention of Obesity-related Cancers: Setting up of a Multi-Cancer Education and Prevention Program in Hong Kong
Obesity could increase the risk of many chronic diseases, including hypertension, cardiovascular diseases, high lipid level, diabetes, stroke, endometrial cancer and certain types of cancer which could benefit by secondary…
- Conditions
- Obesity, Colorectal Cancer, Prostate Cancer, Breast Cancer
- Trial name
- NCT04034953
- Testing
- Faecal Immunochemical Test, Prostate-Specific Antigen Test, Mammogram
- Where
- Hong Kong
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Fallopian Tube Cancer, Ovarian Cancer
Avastin in Combination With Docetaxel in Ovarian/Fallopian Tube/Peritoneum Carcinoma
The purpose of this study is to evaluate the effectiveness of the combination of Avastin and Docetaxel in the treatment of women with platinum sensitive recurrent epithelial ovarian cancer within 12 months of platinum…
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Malignant Tumor of Peritoneum
- Trial name
- NCT00504257
- Testing
- Avastin, Docetaxel
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Vulvar Cancer, Quality of Life
Quality of Life, Unmet Needs and Satisfaction With Care After Vulvar Cancer
The aim of this prospective, longitudinal Swedish multi-center study is to assess the quality of life, treatment-related morbidity, unmet needs and satisfaction with care after treatment for vulvar cancer, evaluated by a…
- Trial name
- PROVE (NCT04152512)
- Testing
- Questionnaire administration
- Where
- 4 sites in Sweden
- Volunteers
- 153 people
- Sponsor
- Karolinska University Hospital
Testicular Cancer, Leukemia
Early Life Exposures in Agriculture
Background: The Agricultural Health Study (AHS) studied farmers and their spouses in North Carolina and Iowa. It also included people who worked with pesticides in Iowa.
- Conditions
- Testicular Cancer, Leukemia, Lymphoma, Brain Cancer
- Trial name
- NCT02743481
- Where
- United States
- Volunteers
- 60,000 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Efficacy, Safety, and Pharmacokinetics of FP-014, 11.25 mg in Patients With Advanced Prostate Cancer
This is a study in male patients with advanced prostate cancer who are eligible for androgen ablation therapy. The study duration will be up to 26 weeks. Eligibility will be assessed during a screening period of up to 28 days.
- Trial name
- KATANA E3M (NCT06795178)
- Testing
- FP-014
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.
BRCA Mutation, Serous Tubal Intraepithelial Carcinoma
International Registration of Isolated STIC: to Report and Investigate the Risk of Serous Peritoneal Carcinomatosis
To prospectively assess the incidence of peritoneal carcinomatosis for women with isolated STIC (serous tubal intraepithelial carcinoma).
- Conditions
- BRCA Mutation, Serous Tubal Intraepithelial Carcinoma, Ovarian Carcinoma, Peritoneal Carcinoma
- Trial name
- STICRISC (NCT06393543)
- Testing
- No intervention, only registration
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
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