Clinical trials: Genital Neoplasms
Polycystic Ovary Syndrome, Anovulation
Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients
Context: Metformin administration in women with polycystic ovary syndrome (PCOS) improves hormonal and metabolic patterns with beneficial effects in terms of reproductive outcomes and intermediate cardiovascular disease risk…
- Trial name
- NCT00953355
- Testing
- Folate plus metformin
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Magna Graecia
Adenomyosis, Leiomyoma
New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma
Both pelvic masses and preoperative diagnosis of them have still continued as an important investigation subject. It is important to discriminate the diagnoses of leiomyoma and adenomyosis before operation especially among…
- Conditions
- Adenomyosis, Leiomyoma, Inflammation
- Trial name
- NCT02997787
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Uterine Cervical Cancer
Clinical Triage and Treatment of Atypical Glandular Cells (AGC) Detected in Screening
The risk of cervical cancer after diagnosis with atypical glandular cells (AGC) detected by screening is elevated for 15 years after discovery.
- Trial name
- NCT05231993
- Testing
- Conization, Colposcopy
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Karolinska Institutet
Non-small Cell Lung Cancer, Colorectal Carcinoma
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Phase I Study, a master protocol to investigate TCR-Engineered T cells recognizing KRAS mutations in adult subjects with Unresectable, Advanced, and/or Metastatic Solid Tumors.
- Conditions
- Non-small Cell Lung Cancer, Colorectal Carcinoma, Pancreatic Ductal Adenocarcinoma, Endometrial Cancer
- Trial name
- NCT06218914
- Testing
- NT-112: Autologous, engineered T Cells targeting KRAS G12D, AZD0240: Autologous, engineered T Cells targeting KRAS G12D
- Where
- 18 sites in United States
- Volunteers
- 108 people
- Sponsor
- AstraZeneca
Prostatic Neoplasms
Vaccine and Antibody Treatment of Prostate Cancer
This study will evaluate the side effects of a fixed dose of vaccine and GM-CSF with increasing doses of anti-CTLA-4 antibody in patients with advanced prostate cancer.
- Trial name
- NCT00113984
- Testing
- PROSTVAC-V/TRICOM, PROSTVAC-F/TRICOM, MDX-010
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Vulvar Cancer
Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes
RATIONALE: Patient abstract not available PURPOSE: Patient abstract not available
- Trial name
- NCT00898352
- Testing
- regional lymph node dissection, radiation therapy
- Sponsor
- Gynecologic Oncology Group
Prostatic Neoplasms, Prostate Cancer
Study of Diagnostic Performance of [18F]CTT1057 for PSMA-positive Tumors Detection
The purpose of this study was to evaluate the diagnostic performance of [18F]CTT1057 as a PET imaging agent for detection and localization of PSMA positive tumors using histopathology as Standard of Truth (SoT).
- Trial name
- GuideView (NCT04838626)
- Testing
- [18F]CTT1057
- Where
- 16 sites in United States, France and 3 more
- Volunteers
- 195 people
- Sponsor
- Novartis Pharmaceuticals
Infertility, Female, Polycystic Ovary Syndrome
IVM Versus IVF: Differences in Patients' Emotional Adjustment and Quality of Life
Patients who undergo in vitro fertilization with or without intracytoplasmic sperm injection (IVF / ICSI) often experience an impact on their quality of life and emotional maladjustment to treatment and outcome.
- Conditions
- Infertility, Female, Polycystic Ovary Syndrome, Psychological Stress, Quality of Life
- Trial name
- EMAQOLIVMIVF (NCT03066349)
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 149 people
- Sponsor
- Universitair Ziekenhuis Brussel
Recurrent Endometrial Cancer
Pembrolizumab in Ultramutated and Hypermutated Endometrial Cancer
Primary Objectives: To assess the antitumor activity (proportion of objective response by RECIST 1.1 criteria) of pembrolizumab with objective tumor response in patients with persistent, recurrent or metastatic endometrial cancer…
- Trial name
- NCT02899793
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Ovarian Cancer, Ovarian Neoplasm
Minimally Invasive Robotic Surgery, Role in Optimal Debulking Ovarian Cancer, Recovery & Survival
MIRRORS "Minimally Invasive Robotic Surgery, Role in Optimal Debulking Ovarian Cancer, Recovery \& Survival" is a new United Kingdom based prospective feasibility study the purpose of which is to establish the feasibility of…
- Conditions
- Ovarian Cancer, Ovarian Neoplasm, Ovarian Neoplasm Epithelial, Fallopian Tube Cancer
- Trial name
- MIRRORS (NCT04402333)
- Testing
- Robotic Interval Debulking Surgery
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Endometrial Cancer, Endometrial Intraepithelial Neoplasia
Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
The goal of this study is to determine the anti-proliferative effect of tirzepatide on the endometrium of patients with endometrial intra-epithelial neoplasia (EIN) and Grade 1 endometrial cancer (EC), by comparing archival…
- Conditions
- Endometrial Cancer, Endometrial Intraepithelial Neoplasia, Grade 1 Endometrial Endometrioid Carcinoma
- Trial name
- NCT07078838
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Cancer
Prostate Advances in Comparative Evidence
This study is an international multicentre randomised study of low, intermediate, and high risk prostate cancer and is composed of three parallel randomisation schemes based on applicability of surgery as a treatment for the…
- Trial name
- PACE (NCT01584258)
- Testing
- Prostatectomy, Conventionally Fractionated Prostate Radiotherapy, Prostate SBRT
- Where
- 68 sites in Canada, Ireland and 2 more
- Volunteers
- 2,205 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Brain Cancer, Prostate Cancer
Feasibility Study of Tumor Blood Flow Measurement by Detection of Positron Activation Post Proton Therapy (DS01)
The purpose of this study is the development of noninvasive (having no direct contact) detector and electronic system that will directly measure tumor blood flow rate.
- Conditions
- Brain Cancer, Prostate Cancer, Lung Cancer
- Trial name
- NCT01987193
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Ovarian Cancer
Fluzoparib Neoadjuvant Therapy for Ovarian Cancer
This study is an interventional, single-arm, open-label clinical trial. To evaluate the safety and efficacy of Fluzoparib as neoadjuvant therapy in patients with FIGO stage III and IV , BRCA mutations or HRD positive epithelial…
- Trial name
- NCT06541314
- Testing
- Fluzoparib
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Qilu Hospital of Shandong University
Cancer
Validation of FACBC for Detection of Metastasis Among High-risk Prostate Cancer Patients With Presumed Localized Disease
This study is for patients who have a high risk of metastatic prostate cancer (cancer that has spread outside of the prostate) who are going to have radical prostatectomy.
- Trial name
- EDRN-FACBC (NCT03081884)
- Testing
- FACBC PET-CT Imaging
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University
Prostate Cancer
Sense of Coherence and Quality of Life in Prostate Cancer Patients Treated With Radical Radiotherapy
This prospective single-group interventional study evaluates the relationship between sense of coherence (SOC), health-related quality of life (HRQL), and self-rated health (SRH) in patients with prostate cancer treated with…
- Trial name
- NCT07431684
- Testing
- Patient-Reported Outcome Assessment (EORTC QLQ-C30, SOC-13, Structured Interview)
- Where
- Slovenia
- Volunteers
- 250 people
- Sponsor
- Institute of Oncology Ljubljana
Prostatic Cancer
Contribution of the VERITON-CT Camera in Prostate Bone Radiostereotaxy
Stereotactic radiotherapy enables bone metastases to be treated with highly precise irradiation beams, enabling small targets to be irradiated.
- Trial name
- VERIOS (NCT06439784)
- Testing
- whole body SPECT/CT
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Prostate Cancer, Prostate Biopsy
The Impact of Video Education on Pain and Anxiety in Patients Undergoing Transrectal Ultrasonography-Guided Prostate Biopsy
This study aimed to assess the impact of dynamic video education versus static images and verbal instruction on pain perception and anxiety in patients undergoing transrectal ultrasound-guided prostate biopsy (TRUS-Bx).
- Conditions
- Prostate Cancer, Prostate Biopsy, Anxiety
- Trial name
- TRUS (NCT07156747)
- Testing
- Visual Analog Scale, State-Trait Anxiety Inventory, Video
- Where
- Turkey (Türkiye)
- Volunteers
- 223 people
- Sponsor
- Ankara Etlik City Hospital
Ovarian Cancer, Fallopian Tube Cancer
Phase 1 Study of a Cancer Vaccine to Treat Patients With Advanced Stage Ovarian, Fallopian or Peritoneal Cancer
Immunotherapy is a novel way to treat cancer and does so by targeting the immune system to destroy tumor cells. Many different therapeutic vaccines have been evaluated in phase 1, 2, and even phase 3 trials.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT01416038
- Testing
- DPX-Survivac, low dose cyclophosphamide (oral)
- Where
- 7 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Infections, Papillomavirus
Human Papillomavirus Vaccine Safety & Immunogenicity Trial in Healthy Young Adult Women With HPV Vaccine (GSK1674330A)
Infection with human papillomavirus (HPV) has been clearly established as the central cause of cervical cancer. Indeed, certain oncogenic types of HPV can infect the cervix (part of the uterus or womb).
- Trial name
- NCT00478621
- Testing
- GSK Biologicals' HPV vaccine (GSK1674330A), Cervarix TM
- Where
- 3 sites in Belgium
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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