Clinical trials: Genitourinary Disease
Acute Kidney Injury
Neutrophil Gelatinase-associated Lipocalin in Major Abdominal Surgery
Acute kidney injury (AKI) after major surgery is a well-known complication. The incidence of AKI after major surgery ranges from 13% to 50%.
- Trial name
- NCT05721638
- Testing
- Neutrophil gelatinase-associated lipocalin
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Antalya Training and Research Hospital
Acute Kidney Injury
Ultra-Low Contrast Angiography in AKI
The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.
- Trial name
- NCT05906758
- Testing
- Angiography
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Hyperparathyroidism, Kidney Disease
Safety and Efficacy Study of Paricalcitol Versus Calcitriol in the Treatment of Secondary Hyperparathyroidism
The purpose of this study is to determine whether oral paricalcitol is safer and more efficacious compared to oral calcitriol in the treatment of hyperparathyroidism in chronic kidney disease patients undergoing dialysis.
- Trial name
- NCT00800358
- Testing
- Paricalitol, Calcitriol
- Where
- 11 sites in Malaysia
- Volunteers
- 69 people
- Sponsor
- Penang Hospital, Malaysia
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Chordoma, Kidney Cancer
- Trial name
- NCT00003926
- Testing
- amifostine trihydrate, busulfan, filgrastim
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
HIV Infections
Effectiveness of Antiretroviral Therapy During Acute HIV Infection
This study will determine whether HIV treatment that is initiated during the acute phase of HIV infection, followed by discontinuation of treatment, is effective in reducing the amount of HIV and an increasing the amount of CD4…
- Trial name
- NCT00705926
- Testing
- Highly Active Antiretroviral Therapy (HAART), No treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Renal Cell Cancer
WIRE - Novel Treatments in Renal Cell Cancer
Evaluation of proof of mechanism with relation to ktrans and/or CD8 count when different IMPs are given as monotherapy or as combination therapy.
- Trial name
- WIRE (NCT03741426)
- Testing
- Olaparib, Cediranib, Volrustomig
- Where
- 7 sites in United Kingdom
- Volunteers
- 134 people
- Sponsor
- CCTU- Cancer Theme
Efficacy and Safety
Evaluation of PLD Combined With Carboplatin Versus Paclitaxel Plus Carboplatin in the First-line Treatment of Epithelial Ovarian Cancer
This is a randomized, multicenter, open, controlled Post-Marketing Study. 396 patients who were histopathology or exfoliated cell pathology of pleural and ascites confirmed with epithelial ovarian cancer/fallopian tube/peritoneal…
- Trial name
- NCT03794778
- Testing
- pegylated liposomal doxorubicin, paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
HIV, Pharmacokinetics
TMC125-TiDP2-C188: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Effect of Multiple-dose TMC125 on Buprenorphine and Norbuprenorphine Administered in HIV-negative Patients on Stable Buprenorphine/Naloxone Maintenance Therapy.
TMC125 is from the class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs work by blocking reverse transcriptase, a protein that HIV needs to make more copies of itself.
- Trial name
- NCT00828815
- Testing
- TMC125
- Volunteers
- 22 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Acute Kidney Injury
Tunneled Dialysis Catheters Versus Non-tunneled Dialysis Catheters as First-line for Renal Replacement Therapy in the ICU
The investigators propose a randomized controlled trial to examine whether tunneled dialysis catheters should be first-line for acute kidney injury requiring renal replacement therapy (AKI-RRT) in the critical care setting…
- Trial name
- BACKDOOR (NCT03496935)
- Testing
- Tunneled versus non-tunneled dialysis catheter insertion
- Volunteers
- 102 people
- Sponsor
- Brigham and Women's Hospital
Cervical Cancer
High Dose Rate Interstitial Brachytherapy With Three Dimensional Printing Template for Recurrent Gynecologic Tumors
This is a single-center study.Eligible patients will have histologically proven pelvic recurrence of cervical cancer after radiotherapy .
- Trial name
- NCT04127435
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Gonorrhea, Chlamydia
Adolescent Sexually Transmitted Infection Screening in the Emergency Department
Sexually transmitted infections (STIs) are highly prevalent among adolescents. Clinical practices related to screening, diagnosis, treatment, and prevention of STIs among adolescents are suboptimal.
- Trial name
- STI (NCT03715335)
- Testing
- Targeted STI Screening, Universally Offered STI Screening
- Where
- 5 sites in United States
- Volunteers
- 98,413 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Urinary Tract Infection (UTI), Complicated Urinary Tract Infection
Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)
This is a Phase 3, multi-site, non-randomized, open-label study evaluating the safety and efficacy of MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g) for the treatment of complicated urinary tract infection (cUTI) including…
- Conditions
- Urinary Tract Infection (UTI), Complicated Urinary Tract Infection, Pyelonephritis, Uncomplicated Pyelonephritis
- Trial name
- NCT02728089
- Testing
- MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g)
- Volunteers
- 115 people
- Sponsor
- Merck Sharp & Dohme LLC
Amenorrhea, Dysmenorrhea
Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation
This is a Phase IV, randomized, double-blind, comparative study of the use of two preparations of ethinyl estradiol and cyproterone acetate in the treatment of menstrual irregularities of hyper-androgenic origin.
- Conditions
- Amenorrhea, Dysmenorrhea, Menstruation Disturbances, Hyperandrogenism
- Trial name
- NCT01103518
- Testing
- Ethinyl Estradiol + Cyproterone acetate
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Fundação Educacional Serra dos Órgãos
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal)
Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS).
- Conditions
- Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn
- Trial name
- NCT07550218
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Urinary Incontinence,Stress, Ultrasound
Ultrasound and Pelvic Floor Muscle Training
The objective is to validate the use of ultrasound measurements (urethral mobility, movement of the ano-rectal angle, elastography measurements) in women with urinary incontiennce before and after pelvic floor muscle training…
- Conditions
- Urinary Incontinence,Stress, Ultrasound, Elastography, Contraction; Pelvic
- Trial name
- ERP (NCT04361890)
- Testing
- perineal ultrasound
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Urolithiasis, Kidney Stone
Flexible Ureteroscopy With Tip-bendable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2-3cm Renal Stones
Background: Percutaneous nephrolithotomy (PCNL) is the first-line treatment for renal stones larger than 2 cm according to EAU and AUA guidelines.
- Trial name
- NCT06526390
- Testing
- f-URS, mini-PCNL
- Where
- China
- Volunteers
- 720 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
End Stage Renal Disease, Hemodialysis
Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients
The purpose of this study is to determine whether on-line hemodiafiltration ameliorate the endothelial dysfunction compared with the low flux hemodialysis in end stage renal disease patients on maintenance hemodialysis.
- Trial name
- NCT00532597
- Testing
- On-line hemodiafiltration, Low flux hemodialysis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Eulji General Hospital
Vaginal Atrophy
Real-world Evidence Study on the Performance and Safety of Halova Ovules
An open-label, multicentric, non-randomized, single-arm, pilot, interventional clinical investigation to confirm the tolerability and performance of the medical device Halova in lubrication of the vagina and vaginal atrophy…
- Trial name
- NCT05654610
- Testing
- Halova
- Where
- 14 sites in Romania
- Volunteers
- 249 people
- Sponsor
- Perfect Care Distribution
Detection and Characterization of Prostate Cancer Based on Artificial Intelligence
Automatic Detection in MRI of Prostate Cancer: DAICAP
Prostate cancer is the most common cancer in France and the 3rd most common cancer death in humans. The introduction of pre-biopsy MRI has considerably improved the quality of prostate cancer (PCa) diagnosis by increasing the…
- Trial name
- DAICAP (NCT05513820)
- Where
- France
- Volunteers
- 1,250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heavy Menstrual Bleeding
Dexamethasone for Excessive Menstruation
This study builds on previous research which has provided compelling evidence that deficient activity of glucocorticoids in the endometrium is a cause of increased menstrual bleeding.
- Trial name
- dexFEM (NCT01769820)
- Testing
- Dexamethasone
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- University of Edinburgh
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