Clinical trials: Genitourinary Disease
Ovarian Cancer
Addition of Herceptin to a Carboplatin-Paclitaxel Regimen in Patients With Ovarian Cancer
The purpose of this study is to evaluate whether or not the addition of Herceptin may be of benefit to a standard regimen of carboplatin-paclitaxel.
- Trial name
- NCT00189579
- Testing
- Herceptin
- Where
- France
- Volunteers
- 45 people
- Sponsor
- ARCAGY/ GINECO GROUP
Fallopian Tube Carcinoma, Malignant Ovarian Mixed Epithelial Tumor
Polyglutamate Paclitaxel and Carboplatin in Treating Patients With Ovarian Epithelial, Peritoneal, or Fallopian Tube Cancer
This phase I trial is studying the side effects and best dose of polyglutamate paclitaxel when given together with carboplatin in treating patients with ovarian epithelial, peritoneal, or fallopian tube cancer.
- Conditions
- Fallopian Tube Carcinoma, Malignant Ovarian Mixed Epithelial Tumor, Ovarian Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma
- Trial name
- NCT00060359
- Testing
- Carboplatin, Paclitaxel Poliglumex, Pharmacological Study
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Gynecologic Oncology Group
Urinary Retention
Normal and Pathological Values of Postvoiding Residual Volume in Early Postpartum Period and Their Predisposing Factors
Aim of this study is to asses post voiding residual volume by ultrasound scan 3th day after delivery with consecutive scan after 6 weeks, and determination of data dispersion among the population of primiparas.
- Trial name
- PAREZ (NCT03958279)
- Testing
- Ultrasound measurement of residual volume in the urinary bladder, Questionnaire
- Where
- Slovakia
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Comenius University
Iron Deficiency Anemia of Pregnancy
Adiposity and Iron Requirements in Pregnancy
This study aims to explore how body fat influences the response to either 25 or 50 mg of daily iron supplements during pregnancy.
- Trial name
- ADIPREG (NCT06425796)
- Testing
- Adiposity and Iron Requirements in Pregnancy (ADIPREG)
- Where
- 3 sites in United Kingdom
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Cervical Cancer, Neoadjuvant Chemoimmunotherapy
Neoadjuvant Chemotherapy Plus Camrelizumab for FIGO Stage IB1 Cervical Cancer
This multicenter, prospective clinical trial is designed to enroll PD-L1 expression-positive patients with stage IB1 cervical cancer who desire fertility preservation to undergo neoadjuvant chemotherapy in combination with a PD-1…
- Conditions
- Cervical Cancer, Neoadjuvant Chemoimmunotherapy, Fertility Preservation
- Trial name
- NCT06289062
- Testing
- Camrelizumab, Cisplatin, Nab paclitaxel
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Tongji Hospital
Uterine Atony With Hemorrhage
Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients
Postpartum hemorrhage remains a leading cause of maternal morbidity and mortality worldwide, even in high income countries. Uterine atony is estimated to cause 70-80% of postpartum hemorrhage.
- Trial name
- NCT03904446
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cynthia Wong
ESRD
Glucose Metabolism During Hemodialysis
Disturbed glucose metabolism is a common feature of patients with end-stage renal disease (ESRD). Several hormones responsible of a stable blood glucose including insulin, glucagon, and the gastrointestinal insulinotropic…
- Trial name
- NCT01800188
- Testing
- Hemodialysis, Hemodiafiltration, Meal test
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Bo Feldt-Rasmussen
Deep Vein Thrombosis, Abdominal Aortic Aneurism
Point-of-care Ultrasound in Finland
This study has two aims. 1. Deep venous thrombosis (DVT) is a common suspected medical condition. If it cannot be excluded clinically and using D-dimer, ultrasound examination is required.
- Conditions
- Deep Vein Thrombosis, Abdominal Aortic Aneurism, Pneumothorax, Gallbladder Diseases
- Trial name
- NCT03327688
- Testing
- Point-of-care ultrasound
- Where
- 4 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Ossi Hannula
HIV Infections
Safety and Acceptability of PRO 2000 Vaginal Gel in HIV Uninfected Women in India
PRO 2000 Gel is designed to be inserted into the vagina to protect women from getting HIV during sex. So far, PRO 2000 Gel has been tested for safety in 136 women from Europe and the United States.
- Trial name
- NCT00081640
- Testing
- PRO 2000/5 Gel (P)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis
Bacterial Vaginosis Home Screening to Prevent STDs
The purpose of this study is to determine whether regular screening (every 2 months) and treatment for bacterial vaginosis (BV [infection of the vagina]) will reduce the number of incidences of chlamydia and gonorrhea (sexually…
- Trial name
- NCT00667368
- Testing
- Metronidazole
- Where
- 7 sites in United States
- Volunteers
- 1,370 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intraepithelial Neoplasia, Cervical Cancer
NWRD09 for HPV-16 Positive and HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer Patients.
This is a single-arm, open label, two cohorts, multi-center clinical study to evaluate the safety and efficacy of HPV-16 targeted mRNA vaccine (NWRD09) in HPV-16 positive and HPV-16 related cervical, vaginal, and vulvar…
- Trial name
- NCT06741150
- Testing
- NWRD09 administered by intramuscular injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Newish Technology (Beijing) Co., Ltd.
Urolithiasis, Strategy Training
Real-World Study of Obstructive Upper Urinary Tract Stones and Acute Pyelonephritis
Upper urinary tract stone obstruction complicated by acute pyelonephritis is a critical urological emergency requiring urgent decompression and infection control, yet real-world clinical decisions regarding the choice between…
- Conditions
- Urolithiasis, Strategy Training, Observation, Pyelonephritis Acute
- Trial name
- NCT07816991
- Testing
- Ureteral Stent, Percutaneous Nephrostomy, Initial Medical Therapy
- Volunteers
- 1,650 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Renal Insufficiency, Chronic, Hypertension
Mobile Health Technology for Chronic Kidney Disease Patients: Medication Management
Patients with complex, long-lasting conditions such as chronic kidney disease (CKD) often take multiple medications and frequently have serious medication problems, arising from poor communication between doctors and patients.
- Conditions
- Renal Insufficiency, Chronic, Hypertension, Medication Reconciliation, Mobile Applications
- Trial name
- NCT02905474
- Testing
- Usual Care, Integrated mobile medication app, Commercially available mobile medication app
- Where
- Canada
- Volunteers
- 182 people
- Sponsor
- University Health Network, Toronto
Sexual Dysfunction, Stress Incontinence
A Study to Measure the Degree and Effectiveness of the Various vSculpt Operating Modes
A pilot study to determine the degree and effectiveness of the various modes of vSculpt, an over-the-counter "OTC" medical device, on enhanced genital blood flow and improvement in quality of life in menopausal women who suffer…
- Trial name
- NCT02856490
- Testing
- vSculpt, InTone
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Joylux, Inc.
HIV/AIDS, Tuberculosis
A Trial of Same-Day Testing and Treatment to Improve Outcomes Among Symptomatic Patients Newly Diagnosed With HIV
This is a randomized, unblinded study comparing standard vs. same-day treatment for patients with TB symptoms (cough, fever, night sweats, or weight loss) at HIV diagnosis.
- Trial name
- NCT03154320
- Testing
- Same-Day Treatment, Standard treatment
- Where
- Haiti
- Volunteers
- 500 people
- Sponsor
- Brigham and Women's Hospital
Preterm Labor
Individualized Dosing of Nifedipine For Tocolysis in Preterm Labor
This study looks at the effects of a mother's genes and other characteristics (mother's age, baby's age, race, and other diseases) on the ability of nifedipine to end contractions and prevent an early delivery.
- Trial name
- NCT02090920
- Testing
- Nifedipine
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Pregnancy Complications, Infectious
Antibiotics for Postpartum Third and Fourth Degree Perineal Tear Repairs
This study is undertaken to find out whether prophylactic antibiotics can decrease the infection rate in third and fourth degree perineal tear repairs done in the immediate postpartum period.
- Trial name
- NCT00186082
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- Stanford University
Hemorrhage, Postoperative Blood Loss
Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery
Some patients undergoing cardiac surgery develop excessive postoperative bleeding. Cardiopulmonary bypass causes platelet dysfunction.
- Trial name
- NCT00885924
- Testing
- Desmopressin
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- St. Olavs Hospital
Metastatic Solid Tumors, Non-small Cell Lung Cancer
Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer
This is a first-in-human, open-label, nonrandomized, four-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX-105 and INBRX-105 in combination…
- Conditions
- Metastatic Solid Tumors, Non-small Cell Lung Cancer, Melanoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- PDL1x41BB (NCT03809624)
- Testing
- INBRX-105 - PDL1x41BB antibody, Pembrolizumab
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Inhibrx Biosciences, Inc
Chronic Kidney Disease (Stages 4 and 5), Mild Cognitive Impairment (MCI)
Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems.
- Trial name
- Exprecoimp-CKD (NCT07160959)
- Testing
- Exercise, Control (Standard treatment)
- Where
- 6 sites in France, Italy and 4 more
- Volunteers
- 124 people
- Sponsor
- Biogem s.c.ar.l.
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