Clinical trials: Genitourinary Disease
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Combination Chemotherapy in Treating Patients With Transitional Cell Cancer of the Urothelium
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
- Trial name
- NCT00014274
- Testing
- carboplatin, gemcitabine hydrochloride, methotrexate
- Where
- 29 sites in Austria, Belgium and 9 more
- Volunteers
- 238 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Acute Kidney Injury Due to Sepsis
Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock
The goal of this clinical trial is to evaluate the efficacy of a hemodynamic resuscitation protocol guided by the Venous Return Gradient (Pmsf - CVP), measured via the non-invasive arm cuff technique, in reducing the incidence of…
- Trial name
- NCT07481097
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
AKI - Acute Kidney Injury
Sevoflurane and Dexmedetomidine's Contrasting Renal Impacts After Non-Cardiac Surgery
Postoperative acute kidney injury (PO-AKI) is a significant complication, especially after complex surgeries. The choice of anesthetic may influence PO-AKI risk.
- Trial name
- NCT06835010
- Testing
- Dexmedetomidine, Sevoflurane inhalant product
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
End Stage Renal Disease
A Simplified Lung Ultrasound Guided Management Protocol Of Pulmonary Congestion in Hemodialysis
Pulmonary congestion secondary to volume overload or interstitial tissue inflammation is common in chronic hemodialysis patients.
- Trial name
- NCT06296160
- Testing
- Intervention Group
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
HIV Infections, Influenza
Incidence of H1N1v Influenza-like Illness and Risk Factors for Serious Influenza Forms in HIV Infected Patients
To estimate the incidence of H1N1v influenza-like illness and to study the risk factors for serious influenza forms during pandemic period in French HIV infected patients.
- Trial name
- ANRS 2H (NCT01039220)
- Testing
- naso-pharyngeal swab
- Where
- France
- Volunteers
- 1,266 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Infertility
Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice Forielle
This is a multicenter, prospective randomized controlled, interventional investigation to assess the safety and clinical performance of Forielle, a medical device for endometrial washing, in restoring favorable endometrial…
- Trial name
- ENDOMEDE (NCT03387059)
- Testing
- Forielle
- Where
- 7 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
HIV-infection/AIDS
Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection
Background: In nearly all people with human immunodeficiency virus (HIV) infection, immunity cannot either control or eradicate the infection.
- Trial name
- HAVARTI (NCT03147859)
- Testing
- Vedolizumab (brand name Entyvio)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Reconstruction, Breast Cancer
Evaluation of Well Being and Patient Reported Outcomes After Robotic Single-port Nipple Sparing Mastectomy and Implant Reconstruction
This study is being carried out to better understand how different types of mastectomy surgeries affect women's recovery, satisfaction, and overall well-being after breast cancer surgery and reconstruction.
- Conditions
- Breast Reconstruction, Breast Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2), Robotic Surgery
- Trial name
- Reborn-i (NCT07236359)
- Testing
- Intervention, Standard open nipple sparing mastectomy with immediate implant-based reconstruction
- Volunteers
- 108 people
- Sponsor
- Beaumont Hospital
Metabolic Cardiovascular Syndrome
Health Improvement After Pregnancy (HIP) Program Randomized Control Trial
Recent Canadian studies, public opinion polls and the Canadian Heart Health Strategy and Action Plan state that women's heart health is a key national priority; it should be addressed through improving heart health awareness and…
- Trial name
- HIP (NCT02077179)
- Testing
- HIP Program
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Queen's University
Premature Birth of Newborn, Critically Ill
The Use of Methadone in Newborn Infants
This proposed investigation will test the following hypotheses: 1) Enzymatic activity of CYP2B6 characterized by the formation clearance of methadone to EDDP (CLf,EDDP), is directly related to both gestational and postnatal age…
- Trial name
- Methadone (NCT01327079)
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- John van den Anker
HIV Infections
Neurocognitive Assessment in Youth Initiating HAART
ATN 071 is a prospective cohort study comparing neurocognitive functioning in four groups of youth, age 18-24: Two groups with CD4+ T cells above 350 cells/mm3 and HIV RNA >1,000 copies/ml, one initiating HAART (Group 1) and the…
- Trial name
- NCT00683579
- Testing
- Early Treatment with HAART, No treatment, HAART Treatment - standard care
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 220 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
This is an open-label study that will measure blood levels of different parts of a drug called GKS189075. People participating in this study will receive a single dose of 250mg GSK189075 by mouth.
- Conditions
- Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, Renal Insufficiency
- Trial name
- NCT00501462
- Testing
- GSK189075
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16
HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3
Randomized, 2-arm observational study. The 2 arms (randomized at the level of health care provider) will be: 1. usual practice; 2.
- Conditions
- Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6
- Trial name
- NCT02558803
- Testing
- Simple Reminder
- Where
- 5 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- Regenstrief Institute, Inc.
Calculi, Urinary, Neurogenic Bladder Disorder
Urinary Calculi After Bladder Augmentation in Children
The goal of this observational study is to analyse the occurence of urinary calculi after bladder augmentation in children: location of the calculi (kidney or bladder) type of bladder augmentation with higher rate of urinary…
- Conditions
- Calculi, Urinary, Neurogenic Bladder Disorder, Spina Bifida, Child, Only
- Trial name
- LITAPED (NCT06734403)
- Testing
- Bladder Augmentation
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Clermont-Ferrand
Polycystic Ovary Syndrome
Effect of Ultrasound Acupoints on Patients With Polycystic Ovary Syndrome
This study will be conducted to evaluate the effect of ultrasound acupoints on menstrual irregularity and hormone levels on polycystic ovary syndrome (PCOS) patient.
- Trial name
- NCT06844903
- Testing
- Pulsed ultrasound at acupuncture points, Standard care program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Kafrelsheikh University
Metastatic Prostate Cancer, Bone Metastasis
Duration of Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Men With Metastatic CRPC
Bone is the most common site of metastases in prostate cancer and bone complications cause substantial morbidity to this population.
- Trial name
- SubDueP (NCT01062503)
- Testing
- Zoledronic acid
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Acquired Immunodeficiency Syndrome, Blood Transfusion
Effectiveness of AIDS Antibody Screening
To determine the effectiveness of efforts to eliminate the human immunodeficiency virus (HIV) from whole blood and blood components in the blood supply.
- Conditions
- Acquired Immunodeficiency Syndrome, Blood Transfusion, HIV Infections
- Trial name
- NCT00005303
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma
Modified Immune Cells (Autologous CAR T Cells) in Treating Patients with Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
This is a Phase I/Ib dose escalation, dose expansion, study to evaluate the safety and identify the recommended dose of modified immune cells PRGN-3005 (autologous chimeric antigen receptor (CAR) T cells developed by Precigen…
- Conditions
- Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Recurrent Fallopian Tube Carcinoma
- Trial name
- NCT03907527
- Testing
- PRGN-3005 UltraCAR-T cells
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- Precigen, Inc
Ovarian Hyperstimulation Syndrome, Infertility Drugs
Transfer of Fresh Versus Frozen/Thawed Embryos in IVF Cycles Where GnRH Agonist is Utilized for Oocyte Maturation.
It has been suggested that in IVF cycles where GNRH agonist is utilized for final oocyte maturation in patients at risk of ovarian hyperstimulation, pregnancy rates are reduced.
- Conditions
- Ovarian Hyperstimulation Syndrome, Infertility Drugs, Female
- Trial name
- NCT00365027
- Testing
- Delayed embryo transfer
- Sponsor
- HaEmek Medical Center, Israel
Brain Development, Behavior Disorders, Child
The Brain Mechanism of Social Emotion and Communication in Infants Aged 0 to 6 Years
This study explores the relationship between brain development and infants' social emotion and communication ability, as well as the role of genetic factors and maternal exposure during pregnancy (e.g., environmental exposures…
- Conditions
- Brain Development, Behavior Disorders, Child, Intellectual Developmental Disorders
- Trial name
- NCT05040542
- Testing
- maternal exposure during pregnancy
- Where
- China
- Volunteers
- 3,001 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
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