Clinical trials: Genitourinary Disease
Cervical Cancers, Vulvar Cancer
A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)
This study will evaluate the immunogenicity and tolerability of V503 (a multivalent human papillomavirus [HPV] L1 virus-like particle [VLP] vaccine) in preadolescent and adolescent participants between 9 and 15 years old and…
- Conditions
- Cervical Cancers, Vulvar Cancer, Vaginal Cancer, Genital Lesions
- Trial name
- NCT00943722
- Testing
- V503
- Volunteers
- 3,074 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Premature Baby 25 to 32 Weeks
Cerebral Abnormalities Detected by MRI, Realized at the Age of Term and the Emergence of Executive Functions
The survival of premature babies increased during the last decades. However, the neurocognitive long term development of these children is worrying, as demonstrated by EPIPAGE 1 study.
- Trial name
- EPIRMEX (NCT02083822)
- Testing
- term MRI, executive EF functions testing
- Where
- 15 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Tours
End-Stage Renal Disease, Stroke
Assessing Cognitive fUnction and MEasuring the Cerebral circulatioN on HaemoDialysis
Stroke disease and cognitive impairment are common in patients established on haemodialysis (HD) for end-stage renal disease (ESRD). Further, initiation of HD appears to transiently increase the risk of stroke.
- Conditions
- End-Stage Renal Disease, Stroke, Cognition Disorders
- Trial name
- ACUMEN-HD (NCT02393222)
- Testing
- Observing effect of routine HD
- Volunteers
- 97 people
- Sponsor
- NHS Greater Glasgow and Clyde
Healthy, Osteoporosis
Hormone Replacement in Young Women With Premature Ovarian Failure
The human ovary produces male sex hormones (androgen) and female sex hormones (estrogen). Currently, androgen is not included in hormone replacement therapy for women with premature ovarian failure.
- Conditions
- Healthy, Osteoporosis, Premature Ovarian Failure
- Trial name
- NCT00001951
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prostate Cancer, Androgen Deprivation Therapy
EvaluatioN of HIFU Hemiablation and Short Term AndrogeN Deprivation Therapy Combination to Enhance Prostate Cancer Control.
The current study aims to examine the hypothesis that combining the focal effects of HIFU with the systemic effects of androgen deprivation therapy might eradicate the prostatic cancer cells by targeting the 'visible' index focus…
- Trial name
- ENHANCE (NCT03845751)
- Testing
- HIFU hemi-ablation combined with ADT.
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Institut Mutualiste Montsouris
Ovarian Cancer
Safety and Efficacy of Ubamatamab With First-line Chemotherapy in Ovarian Cancer
The purpose of this clinical trial is to assess the safety and efficacy of ubamatamab in combination with first-line chemotherapy in patients with ovarian cancer.
- Trial name
- RegeNovar (NCT07637851)
- Testing
- Ubamatamab, Chemotherapy, Bevacizumab
- Where
- 11 sites in France
- Volunteers
- 43 people
- Sponsor
- ARCAGY/ GINECO GROUP
Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
Effectiveness of Perineorrhaphy in Pelvic Organ Prolapse Surgery
This is an observational registry-based study of long-term outcome after vaginal native tissue repair for pelvic organ prolapse designed to emulate a pragmatic open-label two-arm trial for which patients, in whom perineorrhaphy…
- Trial name
- PINPOPS (NCT07006129)
- Testing
- Perineorrhaphy, No perineorrhaphy
- Where
- Sweden
- Volunteers
- 40,646 people
- Sponsor
- Lund University
Gastric Cancer, Invasive Breast Cancer
CONFIRM: Magnetic Resonance Guided Radiation Therapy
This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer.
- Conditions
- Gastric Cancer, Invasive Breast Cancer, in Situ Breast Cancer, Mantle Cell Lymphoma
- Trial name
- CONFIRM (NCT04368702)
- Testing
- Viewray MRIdian® Linac
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Brigham and Women's Hospital
Non-muscle Invasive Bladder Cancer (NMIBC)
Hyaluronic Acid Sodium Salt and Hydeal-D in the Management of LUTS After TURBT for NMIBC.
This will be an open-label, prospective, single-centre, randomised, controlled, parallel-group medical device investigation. The investigational plan will include four visits in total at the investigational site.
- Trial name
- NCT06069453
- Testing
- Hyaluronic Acid (HA) sodium salt and Hydeal-D
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Infertility
Variation in Serum Prolactin Levels During IntraCytoplasmic Sperm Injection
The purpose of the study is to determine whether or not stressful conditions such as ovum pick and awaiting Embryo Transfer is associated with significant increase in serum Prolactin (PRL) concentration in some…
- Trial name
- NCT02292953
- Testing
- Serum Prolactin levels
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Labor Complication
Study of the Fluid Intake Effect During Labour
Ingestion during labor is an issue that has attracted the attention of the scientific community in recent decades, with different practices occurring in different countries.
- Trial name
- NCT06371742
- Testing
- Liquid ingestion during labour
- Where
- Portugal
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Prostate-specific Membrane Antigen Positive Tumors, Prostate Cancer
A Pilot Study of [Ga-68]PSMA PET/MRI for the Assessment of PSMA-positive Tumors
The purpose of this study is to see if positron emission tomography/ magnetic resonance imaging (PET/MRI) can be used to monitor the effectiveness of cancer treatment using an investigational radioactive drug called [Ga-68]PSMA.
- Conditions
- Prostate-specific Membrane Antigen Positive Tumors, Prostate Cancer, Breast Cancer, Lung Cancer
- Trial name
- NCT02978586
- Testing
- [Ga-68]PSMA PET/MR
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Case Comprehensive Cancer Center
Clear Cell Renal Cell Carcinoma
Cemiplimab or Cemiplimab and Fianlimab After Stereotactic Body Radiotherapy in Clear Cell Renal Cell Carcinoma
The purpose of this research is to test the safety of PD-1 inhibitor cemiplimab with or without LAG-3 inhibitor fianlimab, and see what effects (good and bad) of cemiplimab either alone or combined with fianlimab has on patients…
- Trial name
- LAG-BOOST (NCT07223541)
- Testing
- Cemiplimab 350 MG Intravenous Solution, Fianlimab 1600 MG Intravenous Solution
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Oklahoma
Intrauterine Growth Retardation
Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation
OBJECTIVES: I. Determine if mutations in the gene encoding the insulin-like growth factor-I receptor lead to relative insulin-like growth factor-I insensitivity and produce intrauterine growth retardation in children.
- Trial name
- NCT00005105
- Where
- 5 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Center for Research Resources (NCRR)
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
A Study of Islatravir (ISL) and Ulonivirine (ULO) Once Weekly (QW) in Virologically Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8591B-060)
Investigators are trying to find better treatments for people with HIV-1. In this clinical study, investigators want to see how well a new treatment called ISL+ULO, taken once a week, works compared to an existing treatment…
- Trial name
- NCT06891066
- Testing
- ISL, ULO, BIC/FTC/TAF
- Where
- 23 sites in United States, Australia and 2 more
- Volunteers
- 150 people
- Sponsor
- Merck Sharp & Dohme LLC
Bronchopulmonary Disease
Preterm Lung Patient Registry
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival.
- Trial name
- NCT00951366
- Testing
- Patient Registry
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Boston Children's Hospital
Urethral Stricture
The Accuracy of Pulsed Fluoroscopy Retrograde Urethrogram Vs the Traditional Retrograde Urethrogram In Diagnosing Urethral Stricture
This study is designed as a prospective comparative randomized clinical study to determine the diagnostic accuracy (sensitivity, specificity, positive predictive value, and negative predictive value) of pulsed fluoroscopy…
- Trial name
- NCT05519566
- Testing
- Retrograde Urethrogram
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Northern Ontario School of Medicine
Preeclampsia
Comparison of Intravenous Labetalol and Intravenous Hydralazine in Severe Preeclampsia
Due to limited data regarding preeclampsia from the local population, the debate is still ongoing in the study setting. Hence, the current study was planned to compare the efficacy of labetalol and hydralazine for the treatment…
- Trial name
- NCT07572656
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 132 people
- Sponsor
- Muhammad Aamir Latif
Genitourinary; Infection, Complicating Pregnancy
Probiotic Supplementation as Prophylactic for Group B β-hemolytic Streptococcus (GBS) Infection
Streptococcus agalactiae, a Group B β-hemolytic streptococcus (GBS), is the leading cause of severe neonatal infection in developed countries.
- Trial name
- NCT06231056
- Testing
- Probiotic iNatal®
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Intrauterine Growth Restriction
Prediction of Low Birth Weight Infants Using Ultrasound Measurement of Placental Diameter and Thickness
Prediction of Low Birth Weight Infants using Ultrasound Measurement of Placental Diameter and Thickness
- Trial name
- NCT01501851
- Where
- Egypt
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
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