Clinical trials: Genitourinary Disease
Benign Prostatic Hyperplasia
Efficacy of Prostatic Artery Embolization (PAE) in Patients With Severe Benign Prostatic Hyperplasia (BPH)
Purpose: To evaluate the efficacy of prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH) and refractory lower urinary tract symptoms (LUTS) in decreasing the volume of the prostate gland.
- Trial name
- NCT02167919
- Testing
- Microspheres
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of North Carolina, Chapel Hill
Anal Cancer, High-grade Squamous Intraepithelial Lesion
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
The randomized phase of the trial compared topical or ablative treatment with active monitoring in preventing anal cancer in patients with human immunodeficiency virus (HIV) and high-grade squamous intraepithelial lesions (HSIL).
- Conditions
- Anal Cancer, High-grade Squamous Intraepithelial Lesion, HIV Infection, Human Papilloma Virus Infection
- Trial name
- ANCHOR (NCT02135419)
- Testing
- imiquimod, fluorouracil, infrared photocoagulation therapy
- Where
- 25 sites in United States, Puerto Rico
- Volunteers
- 4,446 people
- Sponsor
- AIDS Malignancy Consortium
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
A Pragmatic Approach to CKD Patient Education
Over 350,000 adult Arkansans have chronic kidney disease (CKD) and 9 out of 10 (312,000) of these Arkansans are unaware of having it.
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Patient Engagement
- Trial name
- PACED (NCT05138419)
- Testing
- CKD "What You Need To Know" Workbook System, CKD Action Plan, CKD Web-based Resource List
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Acute Kidney Injury
A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
The purpose of this study is to determine whether THR-184 when administered around the time of cardiac surgery that requires cardiopulmonary bypass can prevent or ameliorate the development of acute kidney injury.
- Trial name
- NCT01830920
- Testing
- THR-184
- Where
- 41 sites in United States, Canada
- Volunteers
- 452 people
- Sponsor
- Thrasos Innovation, Inc.
Chronic Kidney Disease
Putting Patients at the Center of Kidney Care Transitions (PREPARE NOW)
Objective: The investigators will change the health system to improve care patients receive as they transition through earlier stages of kidney disease toward kidney failure.
- Trial name
- NCT02722382
- Testing
- Patient-Centered Kidney Transitions Care
- Where
- United States
- Volunteers
- 1,572 people
- Sponsor
- Duke University
Polycystic Ovarian Syndrome (PCOS), Reproductive Health
Management of Polycystic Ovarian Syndrome-associated Reproductive Dysfunction Through Kefir Supplementation
Polycystic ovary syndrome (PCOS) affect around 6-12% of women of age 18-25 years. Kefir contains bioactive compounds such as lactic acid bacteria, yeast, peptides, polysaccharides and organic acids and acts as a good probiotic…
- Trial name
- NCT07711782
- Testing
- (C0) Control group, (G1) Experimental group
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Lahore
Pregnancy Related, Pelvic Floor Disorders
Perineal Massage Using A Pelvic Wand During Pregnancy
There is limited research on the optimal strategy to reduce obstetric laceration, postpartum urinary retention, and postpartum pelvic pain.
- Conditions
- Pregnancy Related, Pelvic Floor Disorders, Obstetric; Injury, Patient Empowerment
- Trial name
- NCT06986824
- Testing
- Pelvic wand
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Beth Israel Deaconess Medical Center
Preterm Infant, Parents
Transition Model-Based Discharge Training in Parents of Preterm Infants
Infant and Child Monitoring Protocol prepared by the General Directorate of Mother and Child Health and Family Planning of the Ministry of Health regarding the monitoring of postpartum processes in our country.
- Conditions
- Preterm Infant, Parents, Premature Birth, Randomized Controlled Trial
- Trial name
- TRAMPRE (NCT05525624)
- Testing
- TRAMPRE, Control Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Vaginal Wall Prolapse
Surgical Repair of Vaginal Wall Prolapse Using Gamma Irradiated Amniotic Membrane as a Scaffold
The surgical repair of vaginal wall prolapse continues to remain one of the most difficult challenges in female pelvic floor reconstruction. The recurrence rate after standard colporrhaphy ranges from 40-60 %.
- Trial name
- NCT05355623
- Testing
- Vaginal Repair
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Polycystic Ovary Syndrome (PCOS), Insulin Resistance
Evaluation of Serum Preptin Levels in Patients With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age and is strongly associated with insulin resistance and metabolic dysfunction.
- Trial name
- PREPTIN-PCOS (NCT07736079)
- Volunteers
- 60 people
- Sponsor
- GÜLDEN ANATACA
Stage IV Renal Cell Cancer AJCC V7
A Proof of Principle Study of Pembrolizumab With SBRT in TKI mRCC Patients
This study is designed as a phase-II proof of concept trial to investigate if a treatment strategy where stereotactic body radiation therapy (SBRT) is given with pembrolizumab is sufficiently active to warrant further…
- Trial name
- OZM-065 (NCT02599779)
- Testing
- Pembrolizumab, Stereotactic Body Radiation Therapy
- Where
- 3 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Sunnybrook Health Sciences Centre
HIV Infections, Tuberculosis
Efficacy of 400 mg Efavirenz Versus Standard 600 mg Dose in HIV/TB Co-infected Patients
TB is the most common cause of death in patients with HIV worldwide. Rifampicin [RIF] is the cornerstone of anti-TB therapy. Current guideline recommend efavirenz (EFV) 600mg per day as the first of choice for HIV/TB…
- Trial name
- NCT04513379
- Testing
- Efavirenz 600mg, Efavirenz 400mg
- Volunteers
- 80 people
- Sponsor
- Shanghai Public Health Clinical Center
Pediatric Urolithiasis, Distal Ureteral Stone
Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones.
This study will evaluate whether intravesical aminophylline can facilitate semi-rigid ureteroscopic access in children with distal ureteral stones when the first gentle attempt to enter the ureter is unsuccessful.
- Conditions
- Pediatric Urolithiasis, Distal Ureteral Stone, Ureteral Calculi
- Trial name
- NCT07617896
- Testing
- Aminophylline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Kidney Failure, Chronic
Trial of Aerobic Exercise in Patients Undergoing Outpatient Hemodialysis
Randomized controlled trial comparing effects of ergometer exercise during hemodialysis to effects of pedometer use outside of hemodialysis on exercise capacity, functional status, quality of life and adequacy of hemodialysis.
- Trial name
- NCT00492362
- Testing
- ergometer exercise during hemodialysis, pedometer activity outside of hemodialysis
- Where
- 4 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Gestational Diabetes, Mobile Application
eHealth in Treatment of Gestational Diabetes (eMOMGDM)
The overall aim of the eMOM GDM-project is to develop and evaluate a novel system to clinical decision making and patient behavior change in treatment of GDM, combining diet, physical activity, sleep, heart rate (e.g.
- Trial name
- eMOMGDM (NCT04714762)
- Testing
- eMOM GDM application
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Smoke Inhalation Patients
Impact of Hydroxocobalamine on Outcome of Smoke Inhalation Injury Admitted to the ICU
In Europe, hydroxocobalamin (cyanokit) has been used for suspicion of cyanide intoxication associated with the inhalation of fire smoke (1). However, the impact of hydroxocobalamin on outcome has never been thoroughly evaluated.
- Trial name
- COB-AKI (NCT03558646)
- Testing
- There is no intervention planned (observational)
- Where
- France
- Volunteers
- 739 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Postpartum Hemorrhage
Does the Rapid Intravenous Administration of Oxytocin After Delivery of the Baby Decrease the Bleeding During Cesarean Section in Women at Risk of Bleeding During Cesarean Section?
Oxytocin is normally given either rapidly into the vein (bolus) or put into an intravenous bag and administered more slowly, after delivery of the baby by cesarean section. Both of these methods are commonly used.
- Trial name
- NCT00257803
- Testing
- Oxytocin, Saline solution
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HIV Infected Women, Healthy Women Volunteers
Study of Immunity at the Genital Mucosa of HIV-1 Infected and Healthy Women
Current knowledge on mucosa, especially genitals in women, however, remain inadequate, especially regarding defense mechanisms and possibilities for a vaccine to induce an active immune response at mucosal front door of the most…
- Trial name
- MUCOVAC (NCT01715103)
- Testing
- vaginal swabs by washing and cytobrush
- Where
- 2 sites in France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Metastatic Renal Cell Carcinoma
Velcade and Sorafenib in Unresected or Metastatic Renal Cell Carcinoma
This is an open label, non-randomized, single arm phase II study. The primary objective of this study is to investigate the efficacy of combination of sorafenib and VELCADE® (bortezomib).
- Trial name
- NCT01100242
- Testing
- Velcade and Sorafenib
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- New Mexico Cancer Research Alliance
Dysmorphic Uterus
Survey of Dysmorphic Uterus Knowledge Among Gynecologists.
Uterine malformations were initially described by Cruveilhier and Von Rokitansky in the 1800s. Many proposed classifications had been presented over the years, although only two are mostly used worldwide: the first proposed by…
- Trial name
- DUS-1 (NCT04075786)
- Testing
- Survey
- Volunteers
- 300 people
- Sponsor
- Università degli Studi dell'Insubria
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