Clinical trials: Genitourinary Syndrome of Menopause, open to volunteers
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Retrospective Cohort Study of Symptoms and Quality of Life in Women With Genitourinary Syndrome of Menopause.
The goal of this clinical trial is to retrospectively identify the most prevalent symptoms of genitourinary syndrome of menopause (GSM) among postmenopausal women and to evaluate their impact on quality of life.
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause (GSM), Quality of Life
- Trial name
- NCT07737782
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Mucosa Innovations, S.L.
Menopausal Complaints, Vaginal Atrophy
Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV
This is a research study about the effects of vaginal estradiol compared to moisturizer on vaginal symptoms of menopause and the microbiome in women with HIV.
- Conditions
- Menopausal Complaints, Vaginal Atrophy, Genitourinary Symptoms, HIV (Human Immunodeficiency Virus)
- Trial name
- NCT07526948
- Testing
- Vaginal estradiol tablets, Vaginal moisturizer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Genitourinary Syndrome of Menopause (GSM), Bacterial Vaginosis
Photobiomodulation for Vaginal Dysfunctions: Home-Based vs Outpatient Treatment
Vaginal disorders, including vulvovaginal candidiasis (VVC), bacterial vaginosis (BV), and genitourinary syndrome of menopause (GSM), are highly prevalent conditions that significantly affect women's quality of life and sexual…
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Bacterial Vaginosis, Vulvovaginal Candidiasis (VVC)
- Trial name
- NCT07697768
- Testing
- Blue LED Photobiomodulation
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Patricia Lordelo
Genitourinary Syndrome of Menopause (GSM), Breast Cancer
Determining the Extent of the Genitourinary Syndrome of Menopause Burden in Breast Cancer Survivors
Breast cancer survivors (BCS) often face unique challenges during and after treatment, including the onset of menopause-related symptoms.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Breast Cancer, Vulvovaginal Atrophy, Genitourinary Syndrome of Menopause
- Trial name
- V-light cohort (NCT07563621)
- Testing
- Questionnaires (NRS, DASS-21, EORTC QLQ-C30, EORTC QLQ-BR42, FSFI, FSDS-R)
- Where
- Belgium
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Genitourinary Syndrome of Menopause
Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause
Chronic hypoestrogenism in postmenopausal women significantly impacts the urogenital epithelium, leading to Genitourinary Syndrome of Menopause (GSM) and increasing susceptibility to gynecological infections due to vaginal pH…
- Trial name
- NCT06873971
- Testing
- Topical estrogen therapy based on estriol (E3), Active Er:YAG Laser
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.
The goal of this clinical trial is to improve the management of Genitourinary syndrome of menopause (GSM) to preliminary assess safety and effectivity of a novel hormone-free mucosa composition (XCMIM20m) applied topically to the…
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Quality of Life
- Trial name
- STOPGSMP (NCT06962345)
- Testing
- Hormone-free vulvovaginal gel with the tested composition XCMIM20m
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Mucosa Innovations, S.L.
Genitourinary Syndrome of Menopause
Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause
The goal of this randomized controlled trial is to test the efficacy of StrataMGT in the management of Genitourinary Syndrome of Menopause (GSM) compared to estrogen therapy.
- Trial name
- VITAL-E (NCT05672901)
- Testing
- StrataMGT, Estrace 0.01% Vaginal Cream
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stratpharma AG
Atrophic Vaginitis, Vaginal Atrophy
VALOR: Vaginal Atrophy & Long-term Observation of Recovery
Vulvovaginal skin conditions, namely vaginal atrophy, lichen sclerosus, lichen simplex chronicus and lichen planus affecting the female adult population will be treated with a novel gel dressing to test the short- and long-term…
- Conditions
- Atrophic Vaginitis, Vaginal Atrophy, Genitourinary Syndrome of Menopause, Lichen Sclerosus of Vulva
- Trial name
- VALOR (NCT05953090)
- Testing
- 7-0940
- Where
- 14 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stratpharma AG
Genitourinary Syndrome of Menopause
Vaginal Changes After CO2 Laser
Genitourinary syndrome of menopause (GSM) occurs due to a decline in estrogen levels as a woman approaches menopause. The syndrome negatively impacts women's quality of life and is characterized by vaginal dryness, burning…
- Trial name
- OCTRCT (NCT06691178)
- Testing
- Optical coherence tomography (OCT)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Genitourinary Syndrome of Menopause (GSM)
Bipolar Radiofrequency for Genitourinary Syndrome of Menopause
This randomized, sham-controlled clinical trial aims to evaluate the efficacy and safety of bipolar radiofrequency in the treatment of genitourinary syndrome of menopause (GSM) in postmenopausal women.
- Trial name
- BRF-GSM (NCT07419035)
- Testing
- Active bipolar radiofrequency therapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Castilla-La Mancha
Genitourinary Syndrome of Menopause (GSM)
A Clinical Study of Chinese Herbal Formula TJAOA103 in Treating Genitourinary Syndrome of Menopause
The goal of this clinical trial is to learn if Chinese herbal formula TJAOA103 works to treat genitourinary syndrome of menopause (GSM). It will also learn about the safety of TJAOA103.
- Trial name
- NCT07160127
- Testing
- TJAOA103
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Tongji Hospital
Genitourinary Syndrome of Menopause (GSM), Breast Cancer
Efficacy of Non-ablative Radiofrequency Combined With Pelvic Floor Muscle Training for Genitourinary Syndrome of Menopause in Breast Cancer Survivors (RF-SGM)
The goal of this clinical trial is to find out whether non-ablative radiofrequency (RF) applied together with pelvic-floor muscle exercises can ease vaginal dryness and other symptoms of genitourinary syndrome of menopause (GSM)…
- Trial name
- NCT07034976
- Testing
- Active Radiofrequency (Capenergy C500 UpGradeC200)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Genitourinary Syndrome of Menopause
Impact of Oral Supplementation With Bioactive Collagen Peptides and Other Functional Ingredients
Genitourinary Syndrome of Menopause (GSM), characterized by vaginal dryness, pain, urinary incontinence, and other symptoms, can be mitigated through both hormonal and non-hormonal treatments.
- Trial name
- Maicol (NCT07151482)
- Testing
- Collagendep
- Volunteers
- 43 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Menopause, Genitourinary Syndrome of Menopause
Effectiveness of a Telerehabilitation Program for Improving Sexual Function and Reducing Pain in Menopausal Women
The aim of this study is to analyze the effectiveness of a telerehabilitation program with respect to a face-to-face physiotherapy protocol in relation to the improvement of sexual function, the reduction of pain and the…
- Conditions
- Menopause, Genitourinary Syndrome of Menopause, Dyspareunia
- Trial name
- NCT06710002
- Testing
- Pelvify: Menopause and dyspareunia treatment, Face to Face Physical Therapy Protocol, Face to Face Protocol Combined With an Asynchronous Telerehabilitation Program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Instituto Médico Tecnológico SL
Genitourinary Syndrome of Menopause (GSM), Breast Cancer Female
Genitourinary Syndrome of Menopause in Breast Cancer
This randomized, single-blind clinical trial will compare the effectiveness of multimodal pelvic floor physiotherapy (PPT) and fractional CO2 vaginal laser therapy in reducing genitourinary syndrome of menopause (GSM) symptoms…
- Trial name
- PILME (NCT06721936)
- Testing
- Multimodal pelviperineal physioterapy group, Laser CO2 Therapy group
- Where
- Spain
- Volunteers
- 182 people
- Sponsor
- University of Alcala
Genitourinary Syndrome of Menopause
Concomitant Treatment with Topical Hyaluronic Acid and High Concentration Oxygen Therapy (Vaginal Natural Oxygenation Device - VNOD) in the Improvement of Symptoms Related to Genitourinary Syndrome of Menopause in Women with Natural and Oncological Postmenopause: Open-Label, Single-Center, Randomize
The Caress study is a single-center, open-label, randomized controlled trial (RCT) evaluating the efficacy of a combined treatment using topical hyaluronic acid and high-concentration oxygen therapy (Vaginal Natural Oxygenation…
- Trial name
- Caress (NCT06879938)
- Testing
- High-concentration vaginal oxygen therapy (Caress Flow) with topical hyaluronic acid, hyaluronic acid-based gel (Hydeal-D®)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Postmenopausal Atrophic Vaginitis, Genitourinary Syndrome of Menopause
Difference in Serum Estrogen Level Based on Methods of Vaginal Estrogen Application (fingertip Vs Applicator Use) in Post-menopausal Women
Study the change in serum estrogen level based on the method of vaginal cream application (applicator vs fingertip application) and Measure patient satisfaction with vaginal estrogen cream application based on the method of…
- Trial name
- NCT06808347
- Testing
- application of the vaginal estrogen cream
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Genitourinary Syndrome of Menopause
Intravaginal Negative Pressure Medical Device for Treatment of Genitourinary Syndrome of Menopause (GSM)
This pilot study aims to evaluate the safety and effectiveness of the VITA AV Clinical System over a period of up to three months after the last treatment, compared to a sham device.
- Trial name
- NCT06768073
- Where
- 2 sites in United States, Georgia
- Volunteers
- 60 people
- Sponsor
- AVeta Medical
Genitourinary Syndrome of Menopause
Vaginal CO2 Laser Therapy for Genitourinary Syndrome in Breast Cancer Survivors
This project will be based on three studies over a period on three years. The first study is a dose response study that includes 30 breast cancer survivors.
- Trial name
- NCT06007027
- Testing
- SmartXIDE2V2LR, Monalisa Touch, DEKA, Florence, Italy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus