Clinical trials: Genitourinary Syndrome of Menopause (GSM)
Genitourinary Syndrome of Menopause
Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy
We have recently developed and optimized a vaginal Optical Coherence tomography/angiography endoscopy imaging system. This technology is able to obtain a comprehensive image of the vaginal epithelium, blood vessels, and lamina…
- Trial name
- NCT04737616
- Testing
- CO2 laser, OCT
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
PRP, Sexual Function Disturbances
PRP Injections for Genitourinary Syndrome of Menopause
Platelet-rich plasma (PRP) is autologous blood which has been centrifuged to separate the supernatant resulting in a solution with high concentration of platelets.
- Conditions
- PRP, Sexual Function Disturbances, Genitourinary Syndrome of Menopause, Postmenopausal Symptoms
- Trial name
- NCT06028009
- Testing
- Injection of platelet-rich plasma, Injection of saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Vaginal Atrophy Patients With GSM
The Effect Of Fractional CO2 Laser Therapy On Cancer Survivors With Genitourinary Syndrome Of Menopause (GSM)
Improvement in cancer therapies has led to an increase in the number of women surviving chemotherapy (and other treatments) and overcoming cancer.
- Trial name
- NCT06318052
- Testing
- The FemTouch delivery system, Gynomunal gel treatment
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Lumenis Be Ltd.
Vaginal Atrophy, Dyspareunia
Elastographic Improvement of Vaginal Atrophy Treated by Erbium Yag Laser
This study is a randomized controlled sham applied study. Its aim is to evaluate the efficacy of Er:YAG laser for the treatment of atrophic vaginitis in postmenopausal women.
- Conditions
- Vaginal Atrophy, Dyspareunia, Laser, Genitourinary Syndrome of Menopause (GSM)
- Trial name
- NCT06000202
- Testing
- Fotona Dynamis Er:YAG Laser System
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University - Cerrahpasa
Genitourinary Syndrome of Menopause (GSM)
A Randomized, Single Center Pilot Study Comparing Hyaluronic Acid to Vaginal Estrogen for Treatment of Genitourinary Syndrome of Menopause
Non-hormonal alternatives for the treatment of genitourinary syndrome of menopause (GSM) are needed. In this proposed trial, patients who are diagnosed with GSM will be randomized to receive either a hyaluronic acid (HLA) vaginal…
- Trial name
- NCT04544475
- Testing
- Revaree, Estrace
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Genitourinary Syndrome of Menopause
Impact of Oral Supplementation With Bioactive Collagen Peptides and Other Functional Ingredients
Genitourinary Syndrome of Menopause (GSM), characterized by vaginal dryness, pain, urinary incontinence, and other symptoms, can be mitigated through both hormonal and non-hormonal treatments.
- Trial name
- Maicol (NCT07151482)
- Testing
- Collagendep
- Volunteers
- 43 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Genitourinary Syndrome of Menopause (GSM)
Effects of Fractional CO2 Vaginal Laser in Postmenopausal Women With Genitourinary Syndrome of Menopause
This study evaluated the effects of fractional carbon dioxide (CO2) vaginal laser treatment in postmenopausal women with genitourinary syndrome of menopause.
- Trial name
- NCT07858994
- Testing
- Fractional CO2 Vaginal Laser
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Karina Amar Svec
Genitourinary Syndrome of Menopause
RCT of Laser Therapy for GSM
The aim of the current study is to assess whether the CO2-laser results in superior alleviation of GSM symptoms compare to Er:YAG-laser.
- Trial name
- NCT03288883
- Testing
- Photothermal Non-ablative Erbium:YAG-laser, Fractional Microablative CO2-laser
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Genitourinary Syndrome of Menopause (GSM), Breast Cancer
Efficacy of Non-ablative Radiofrequency Combined With Pelvic Floor Muscle Training for Genitourinary Syndrome of Menopause in Breast Cancer Survivors (RF-SGM)
The goal of this clinical trial is to find out whether non-ablative radiofrequency (RF) applied together with pelvic-floor muscle exercises can ease vaginal dryness and other symptoms of genitourinary syndrome of menopause (GSM)…
- Trial name
- NCT07034976
- Testing
- Active Radiofrequency (Capenergy C500 UpGradeC200)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Genitourinary Syndrome of Menopause (GSM), Breast Cancer Female
Genitourinary Syndrome of Menopause in Breast Cancer
This randomized, single-blind clinical trial will compare the effectiveness of multimodal pelvic floor physiotherapy (PPT) and fractional CO2 vaginal laser therapy in reducing genitourinary syndrome of menopause (GSM) symptoms…
- Trial name
- PILME (NCT06721936)
- Testing
- Multimodal pelviperineal physioterapy group, Laser CO2 Therapy group
- Where
- Spain
- Volunteers
- 182 people
- Sponsor
- University of Alcala
Genitourinary Syndrome of Menopause (GSM)
Via, a Hyaluronic Acid (HLA) Based Vaginal Moisturizer Study
This study aims to evaluate whether the administration of vaginal estrogen along with Via, a hyaluronic acid-based vaginal moisturizer, offers superior relief from symptoms of genitourinary syndrome of menopause (GSM) in the…
- Trial name
- NCT07038070
- Testing
- Vaginal estrogen tablet, Via Solv Wellness (Hyaluronic Acid Therapy)
- Where
- United States
- Sponsor
- NYU Langone Health
Vaginal Atrophy, Genitourinary Disease
Effect of Hybrid Laser 10600+1540 nm on GSM
The primary objective of the study is to clinically confirm, by comparison with a control group, the performance of the 10600 +1540 nm laser in the improvement of atrophic vaginal epithelium at 3 months after the last laser…
- Trial name
- NCT03956563
- Testing
- Youlaser MT Group 2, Youlaser MT Group 1
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Quanta System, S.p.A.
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.
The goal of this clinical trial is to improve the management of Genitourinary syndrome of menopause (GSM) to preliminary assess safety and effectivity of a novel hormone-free mucosa composition (XCMIM20m) applied topically to the…
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Quality of Life
- Trial name
- STOPGSMP (NCT06962345)
- Testing
- Hormone-free vulvovaginal gel with the tested composition XCMIM20m
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Mucosa Innovations, S.L.
Women With Breast Cancer
Effect of Intravaginal Prasterone on Symptoms of Genitourinary Syndrome of Menopause (GSM) in Women in Menopause With Previous Breast Cancer
The goal of this interventional study is to evaluate the effect of Intravaginal Prasterone for the treatment of moderate to severe symptoms of genitourinary syndrome (GSM) due to natural, surgical or treatment-induced menopause…
- Trial name
- PROPOSE (NCT06611514)
- Testing
- Prasterone (DHEA)
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- European Institute of Oncology
Genitourinary Syndrome of Menopause
Laser Therapy for Treatment of Genitourinary Syndrome of Menopause (GSM) in Postmenopausal Women
This is a prospective, multi-centre, double blinded, randomized controlled trial, which will be conducted under a common protocol.
- Trial name
- LASER_2022 (NCT05305209)
- Testing
- Intervention group, Control Group
- Where
- Spain
- Volunteers
- 189 people
- Sponsor
- University of Malaga
Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness
Pilot Study of Individualized Treatment for Genitourinary Syndrome of Menopause in Women After Cancer Treatment
This pilot study is designed to evaluate an individualized approach to the treatment of genitourinary syndrome of menopause (GSM) in women who have undergone oncological treatment.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness, Menopause, Female Cancer Survivors
- Trial name
- NCT07420647
- Testing
- Non-ablative vaginal Er:YAG laser therapy, Standard care
- Where
- Slovenia
- Volunteers
- 65 people
- Sponsor
- Institute of Oncology Ljubljana