Clinical trials: Genome
Bladder Urothelial Carcinoma, Urothelial Carcinoma
Copper Cu-64 TP3805 PET/CT in Imaging Patients With Urothelial Cancer Undergoing Surgery or Biopsy
This pilot clinical trial studies how well copper Cu-64 TP3805 positron emission tomography (PET)/computed tomography (CT) works in imaging patients with urothelial cancer undergoing surgery or biopsy.
- Trial name
- NCT03039413
- Testing
- Copper Cu 64 TP3805, Positron Emission Tomography, Computed Tomography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Cardiogenic Shock
Genomic Determinants of Outcome in Cardiogenic Shock
The aim of this project is to understand the heterogeneity of both the immune consequences and treatment responses in CS. We will explore this heterogeneity through identification of transcriptomic sub-phenotypes and their…
- Trial name
- Goldilocs (NCT05728359)
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Barts & The London NHS Trust
Advanced Solid Tumors, Breast Cancer Recurrent
First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers
The goal of this study is to identify a safe and tolerated dose of the orally administered DHX9 inhibitor ATX-559. In addition, this study will evaluate the pharmacokinetics, pharmacodynamics and preliminary antitumor activity of…
- Conditions
- Advanced Solid Tumors, Breast Cancer Recurrent, Colorectal Cancer Metastatic, Colon Cancer
- Trial name
- NCT06625515
- Testing
- ATX-559
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- Accent Therapeutics
Rett Syndrome
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization
Rett syndrome (RTT) is a genetic encephalopathy and the typical form is caused by mutations in the gene MECP2. It is a genetically heterogeneous pathology.
- Trial name
- RETT (NCT02885090)
- Testing
- Blood sampling
- Where
- 9 sites in France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Genomic Instability, Prognostic Cancer Model
Genomic Signatures for Patients With Initially Unresectable Colorectal Liver Metastases
A retrospective cohort of 286 patients with synchronous CRLM underwent conversion therapies based on next-generation sequencing (NGS) results.
- Trial name
- NCT06477718
- Volunteers
- 286 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Arrhythmia, Cardiovascular Diseases
Diagnostic Investigation of Sudden Cardiac Event Risk
The overall objective of the DISCERN study is to develop and validate a genomic diagnostic assay to identify patients at increased risk for lethal ventricular arrhythmias and sudden cardiac death (SCD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Failure, CVD
- Trial name
- DISCERN (NCT00500708)
- Where
- 8 sites in United States
- Volunteers
- 1,564 people
- Sponsor
- CardioDx
Chronic Pain
Existential Genomics: Effects of Multimodal Rehabilitation and Integrative Care on Patients With Chronic Pain
Using a comprehensive prospective clinical study design, the investigators intend to compare changes in health-related markers in patients with chronic widespread pain (CWP), undergoing one of two intervention "packages" of…
- Trial name
- ExiGence (NCT02459639)
- Testing
- Anthroposophic integrative care rehabilitation program, Conventional multi-modal care rehabilitation
- Volunteers
- 100 people
- Sponsor
- The Integrative Care Science Center
Neurotoxicity Syndromes
To Study the Individual Variants of Chemotherapy-Induced Neurotoxicity
To study the risk prediction of chemotherapy-induced peripheral neuropathy (CIPN) by the clinical bioinformatics and genomic profile.
- Trial name
- NCT02481336
- Testing
- Questionnaires, Peripheral nervous system examination, Whole Genome Sequence
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Pancreas Adenocarcinoma, Cachexia
Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma
A major complication of pancreatic adenocarcinoma (PDAC) is cancer cachexia (CC) which is a complex syndrome characterized by skeletal muscle mass loss (with or without loss of fat mass) and progressive functional impairment not…
- Trial name
- NCT05376592
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Endometrial Cancer
ctDNA Assessment in Endometrial Cancer for Adjuvant Therapy
The goal of this observational study is to evaluate whether combining postoperative circulating tumor DNA (ctDNA) testing with a novel genomic risk model can better predict recurrence risk and guide adjuvant therapy decisions in…
- Trial name
- NCT07681414
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Guizhou Provincial People's Hospital
Cervical Cancer, Cervix
Assessment of EGFR Genomic Alterations as Prognostic Markers in Cervical Cancer
The Tissue Repository will search for cases, pull slides, Paraffin-embedded tissue (PET) blocks.
- Trial name
- NCT00298064
- Testing
- Tissue Repository
- Where
- United States
- Sponsor
- University of New Mexico
Sickle Cell Disease
Long-term Follow-up (LTFU) of Patients Treated With Genome-edited Autologous Hematopoietic Stem and Progenitor Cells (HSPC)
CADPT03A12001 is a prospective, multi-center study that is designed to follow all enrolled patients who have received treatment with OTQ923 for long-term safety and efficacy.
- Trial name
- NCT06155500
- Testing
- OTQ923
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Cancer
Characterization of Human Cancers by Molecular Profiling of Patient Biospecimens
Purpose of the Protocol: To prospectively identify cancer patients whose tumors express specific molecular markers targeted by therapeutic agents, for the purpose of selecting the most clinically appropriate anticancer therapy…
- Trial name
- NCT02749838
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Pharmatech
Genetic Disease
Newborn Genomic Sequencing Pilot Study
The goal of this clinical trial is to test a new method for newborn screening using whole genome sequencing, called BeginNGS. Newborns who are not suspected of having genetic diseases and who are admitted to the NICU at Rady…
- Trial name
- NCT06276348
- Testing
- Whole genome sequencing, BeginNGS test, WES
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rady Pediatric Genomics & Systems Medicine Institute
Periodontal Disease "Unrecognized Condition"
Design of a Protocol for Obtaining Genomic DNA From Saliva
Objective The aim of this study was to test a protocol for the extraction of high quality genomic DNA from saliva samples obtained with mouthwash and taken from patients with periodontal disease.
- Trial name
- DPOGDNAS (NCT02523326)
- Testing
- saliva samples obtained with mouthwash
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Centro Interdisciplinario de Ciencias de la Salud Unidad Santo Tomás
Solid, Liquid, Central Nervous System Tumors
Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients
The development of next generation sequencing (NGS) techniques, including whole genome (WGS), exome (WES) and RNA sequencing has revolutionized the ability of investigators to query the molecular mechanisms underlying tumor…
- Trial name
- NCT02530658
- Testing
- Study Introduction Visit, Informed Consent Visit, Informed Consent Follow-Up Visit
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- St. Jude Children's Research Hospital
Thrombotic Thrombocytopenic Purpura, Acquired
Association of TNFAIP3 With Immune-mediated TTP
This study aims to investigate whether genetic variation in the TNFAIP3 locus is associated with immune-mediated thrombotic thrombocytopenic purpura (iTTP), and whether such association is mediated by decreased expression of A20…
- Trial name
- A20iTTP (NCT06928233)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sarcoma
Study of Blood Samples From Patients With Ewing Sarcoma and Their Relatives
RATIONALE: Studying samples of blood in the laboratory from patients with cancer and their relatives may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- GENEWING (NCT01210209)
- Testing
- genome-wide association study
- Where
- France
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Institut Curie
Breast Cancer
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are…
- Trial name
- FLEX (NCT03053193)
- Testing
- MammaPrint, BluePrint, and Full-Genome Testing
- Where
- 134 sites in United States, Canada and 2 more
- Volunteers
- 30,000 people
- Sponsor
- Agendia
Developmental Anomalies
Study of the Diagnostic Value of "Rapid" High Throughput Genome Sequencing Analysis in Diagnostic Emergency Situations
Rare diseases (affecting less than one in 2,000 people) are a major public health issue. There are about 8,000 rare diseases and they affect more than 3 million people in France.
- Trial name
- FASTGEN (NCT03956069)
- Testing
- blood sample, genome sequencing
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
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