Clinical trials: Genome
Pancreatic Cyst
Genomic Profiling of Pancreatic Cystic Tumors
This study aims to find out whether quantitative and qualitative analysis, including genetic mutation analysis, of samples obtained from patients with pancreatic cysts is associated with the risk of malignancy, and helpful in the…
- Trial name
- NCT06195904
- Testing
- NA (No intervention)
- Where
- 2 sites in South Korea
- Volunteers
- 250 people
- Sponsor
- Samsung Medical Center
Prostate Cancer, Adenocarcinoma of the Prostate
Neoadjuvant Docetaxel on Newly Diagnosed Intermediate and High Grade Cancer of the Prostate
This pilot phase II trial studies docetaxel and prednisone in treating patients with newly diagnosed stage I-II prostate cancer undergoing prostatectomy.
- Conditions
- Prostate Cancer, Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage II Prostate Cancer
- Trial name
- 2007-5904 (NCT00598858)
- Testing
- Docetaxel, Prednisone
- Sponsor
- John P. Fruehauf
Health Services Administration, Genetic Predisposition
Genome Driven Primary Care Clinics - an RCT
A cluster randomized controlled study of 40 primary care clinics in Northern Israel (20 intervention clinics, 20 usual care clinics) to evaluate the value of introducing a precision medicine/genomic approach/paradigm on the…
- Conditions
- Health Services Administration, Genetic Predisposition, Microbial Colonization
- Trial name
- NCT04781205
- Testing
- Mutation arrays, NGS panels, GWAS, WES, WGS,, wearable monitors
- Where
- Israel
- Volunteers
- 200,000 people
- Sponsor
- Carmel Medical Center
Microgravity, Neuroplasticity
Neuroimage Genome Study of Neuroplasticity Associated With Microgravity
This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and…
- Conditions
- Microgravity, Neuroplasticity, MRI, Repeatable Battery for the Assessment of Neuropsychological Status
- Trial name
- NCT06350422
- Testing
- Head-Down tilt Bed Rest test
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Leukemia
S8600-S9031-S9333-A, Study of DNA in Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01434329
- Testing
- DNA methylation analysis, gene expression analysis, microarray analysis
- Volunteers
- 200 people
- Sponsor
- SWOG Cancer Research Network
Small Renal Mass, Kidney Tumor
GRADE-SRM: Genomic Risk Assessment and Decisional Evaluation for Small Renal Masses
Purpose: The purpose of this study is to evaluate the role of renal mass biopsy on decision-making for patients presenting with clinical T1 kidney tumors.
- Trial name
- GRADE-SRM (NCT03819569)
- Testing
- Small Renal Mass Biopsy, No Small Renal Mass Biopsy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Fetal Anomaly, Bereavement
Modified Delphi for Genomic Bereavement Care
It is estimated that 1 in 4 pregnancies end in loss, be these early miscarriages, ectopic pregnancies, or later intrauterine losses for any reason.
- Conditions
- Fetal Anomaly, Bereavement, Genetic Disease
- Trial name
- NCT05655741
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Healthy, Learning
Use of Virtual Reality to Communicate Concepts of Genomics to the General Public
This study will investigate how people learn best about genetics. It involves participating in activities in NHGRI's Immersive Virtual Environment Laboratory (IVE lab), where digital "virtual worlds" are created that appear to…
- Conditions
- Healthy, Learning, Communication
- Trial name
- NCT00316056
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Positron-Emission Tomography, Non-small Cell Lung Cancer
Diagnostic Significance of Single Center, Open and Prospective Evaluation of <Sup>18<Sup>F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesions and Differentiating Multiple Primary Lung Cancer From Intrapulmonary Metastases of Non-small Cell Lung Cancer
The purpose of this study is to evaluate the diagnostic value of 18F-FDG PET/CT dynamic imaging in metastasis of non-small cell lung cancer (NSCLC).
- Trial name
- NCT03679936
- Testing
- PET/CT dynamic scan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Non Small Cell Lung Carcinoma
Concordance of Key Actionable Genomic Alterations as Assessed in Tumor Tissue and Plasma in Non Small Cell Lung Cancer
A study to determine the concordance of key actionable genomic alterations as assessed in tumor tissue and plasma from patients with non small cell lung carcinoma (NSCLC)
- Trial name
- NCT02762877
- Where
- 22 sites in United States, Chile and 5 more
- Volunteers
- 140 people
- Sponsor
- Genomic Health®, Inc.
Aging
Study of the Safety and Efficacy of Natural Genome Reconstruction Technology of Hematopoietic Stem Cells in Adult Patients
This pilot randomized, double-blind, placebo-controlled study evaluates the safety and efficacy of the hDNAgr technology aimed at natural genome reconstruction in hematopoietic stem cells in adults aged 45-65.
- Trial name
- NCT06877377
- Testing
- hDNAgr Therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- S.LAB (SOLOWAYS)
Cancer
Incidental Genomics
Health care providers (HCP) are increasingly using genomic sequencing (GS) to diagnose diseases and target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases.
- Trial name
- NCT03597165
- Testing
- Incidental Genomic Sequencing Results, GS Results for Primary Indications only
- Where
- 3 sites in Canada
- Volunteers
- 289 people
- Sponsor
- Unity Health Toronto
Gastric Adenocarcinoma, Stage II Gastric Cancer
Irinotecan and Cisplatin in Treating Patients Who Are Undergoing Surgery For Locally Advanced Cancer of the Stomach or Gastroesophageal Junction
This phase II trial is studying how well giving irinotecan together with cisplatin works in treating patients who are undergoing surgical resection for locally advanced cancer of the stomach or gastroesophageal junction.
- Conditions
- Gastric Adenocarcinoma, Stage II Gastric Cancer, Stage III Gastric Cancer, Stage IV Gastric Cancer
- Trial name
- NCT00062374
- Testing
- Cisplatin, Computed Tomography, Fludeoxyglucose F-18
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Neurofibromatosis, MPNST
Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1
Background:<TAB> Many people with neurofibromatosis type 1 (NF1) get tumors of the nervous system. Finding malignant tumors early is important for removing them.
- Trial name
- NCT02211768
- Testing
- MRI, FDG-PET/CT scans, [18F]-FLT-PET/CT scans
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Vitamin D Deficiency
The GLOBAL Vitamin D Study. A Genomic, Transcriptomic, Proteomic and Metabolomic Approach
The effect of vitamin D supplementation on genetic, proteomic , and metabolomic profile in adipose tissue will be studied in 50 subjects.
- Trial name
- NCT02783924
- Testing
- Cholecalciferol
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Breast Cancer
Utilization of Genomic Signature as Decision-making for Adjuvant Treatment of Breast Cancer
Method: This multicentric prospective cohort is composed of patients with no metastatic breast cancer selected by tumor's genomic analysis and treated by chemotherapy with Anthracycline without Taxanes (6 cycles of FEC 100).
- Trial name
- SA02 (NCT00912080)
- Testing
- genomic signature
- Where
- 4 sites in France
- Volunteers
- 375 people
- Sponsor
- Institut Paoli-Calmettes
Epithelial Ovarian Cancer, Epithelial Ovarian Tumor of Borderline Malignancy
A Genomic Analysis of Evolution of Epithelia Ovarian Tumors
Epithelial ovarian carcinomatous and borderline components sometimes appeared in one patient. This study aims to analyze the genomic patterns of the carcinomatous and borderline components in the ovarian epithelial tissues.
- Conditions
- Epithelial Ovarian Cancer, Epithelial Ovarian Tumor of Borderline Malignancy, Driving Mutations, Progression-free Survival
- Trial name
- NCT03742388
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lei Li
Narcolepsy Type 1
Clinical and Neurophysiological Characteristics of Narcolepsy
The study is the first attempt in post-Soviet Russian history to collect and analyze the existing available data of narcolepsy cohort in order to get prove characteristics of narcolepsy in Russia according to known data.
- Trial name
- NCT05375890
- Testing
- no intervention
- Where
- 11 sites in Russia
- Volunteers
- 89 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Autism Spectrum Disorder, Neurodevelopmental Disorders
Platform for the Prospective Mother-child Study of the Determinants of Neurodevelopmental Disorders
Neurodevelopmental disorders such as attention deficit disorder with or without hyperactivity, autism spectrum disorder, language and social communication disorder, motor coordination disorder, learning disorder (dyslexia…
- Trial name
- MARIANNE (NCT05681923)
- Testing
- Questionnaires, Biospecimen collection, Neurodevelopmental assessment visit
- Where
- France
- Volunteers
- 7,320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Leukemia
Studying DNA in Blood and Bone Marrow Samples From Young Patients With Acute Lymphoblastic Leukemia
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01016379
- Testing
- DNA analysis, biologic sample preservation procedure, laboratory biomarker analysis
- Volunteers
- 1,000 people
- Sponsor
- Children's Oncology Group
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