Clinical trials: Genome
Solid Tumor, Microsatellite Instability
APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors
The purpose of this study is to determine the safety, tolerability, and recommended dose schedule of APL-501 in individuals with advanced or relapsed or recurrent solid tumors.
- Conditions
- Solid Tumor, Microsatellite Instability, Mismatch Repair Deficiency, Cancer of Unknown Primary Site
- Trial name
- NCT03053466
- Testing
- APL-501
- Where
- 5 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Apollomics (Australia) Pty. Ltd.
Breast Cancer
Study of Blood Samples From High-Risk Postmenopausal Women Who Received Treatment on Breast Cancer Prevention Clinical Trials NSABP-P-1 or NSABP-P-2
RATIONALE: Studying the genes expressed in samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00967239
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Volunteers
- 1,881 people, healthy volunteers welcome
- Sponsor
- NSABP Foundation Inc
Colorectal Cancer
Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan
We will explore the genetic (including APC, k-ras, p53, MSI, etc.) and environmental (including family history, life style, diet, nutritional status, DM, serum IGF-I, IGFBP-3, etc.) risk factors of colorectal tumorigenesis.
- Trial name
- NCT00172757
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pharmacogenomics, Medication Therapy Management
A Pharmacist Implemented Pharmacogenomics Service in the Program of All-inclusive Care for the Elderly
The aim of this study is to evaluate and describe the feasibility of implementing a pharmacist-led pharmacogenomics service for the Program of All-inclusive Care for the Elderly (PACE), a community-based practice setting.
- Trial name
- PACE (NCT03257605)
- Volunteers
- 296 people
- Sponsor
- Tabula Rasa HealthCare
Kawasaki Disease
Clinical Precise Diagnosis and Treatment in the Kawasaki Disease
The purpose of this project is to explore the differential gene expression profile of Kawasaki disease, and will explore the diagnosis and treatment targets related to coronary artery injury or kawasaki disease susceptibility…
- Trial name
- NCT05347901
- Testing
- Echocardiography, Genomics NGS sequencing
- Where
- 4 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Carcinoma, Hepatocellular, Liver Cirrhosis, Alcoholic
A Study of Molecular and Genetic Factors for Liver Cancer in the Greater Baltimore Area
Background: Liver cancer is the third most deadly and fifth most common cancer worldwide. Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, and it has grown more prevalent in the United States.
- Conditions
- Carcinoma, Hepatocellular, Liver Cirrhosis, Alcoholic, Hepatitis, Alcoholic, Hepatitis, Chronic
- Trial name
- NCT00913757
- Where
- 2 sites in United States
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
NSCLC
Whether Sputum Can Serve as an Alternative Source for Liquid Biopsy in Patients With Lung Cancer
This study intends to use Onconscreen plus 520 Panel (Burning Rock, China) to conduct NGS testing in sputum, tissues and blood samples of patients with advanced NSCLC.
- Trial name
- NCT05034445
- Testing
- Next generation sequencing
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Cardiovascular Phenotype, Metabolic Phenotype
Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study
Background: Mosaicism is a condition in which cells within the same person have a different genetic makeup. Sometimes, a type of mosaicism called 45,X may not be discovered in a woman until she undergoes routine tests during…
- Conditions
- Cardiovascular Phenotype, Metabolic Phenotype, Hypertensive Disease, Psychological Phenotype
- Trial name
- NCT05548881
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Colorectal Neoplasms, Hereditary Nonpolyposis Colorectal Cancer
Implementation of a New Strategy to Identify HNPCC Patients
The purpose of this study is to compare two different strategies to implement a new method to identify patients with HNPCC, which appeared cost-effective and feasible.
- Trial name
- NCT00141466
- Testing
- Education for professionals, Distribution of educational materials, Feedback for professionals
- Where
- 13 sites in Netherlands
- Volunteers
- 360 people
- Sponsor
- Radboud University Medical Center
Acute Leukemia
Physical Activity in Acute Lymphoblastic Leukemia (ALL)
Acute lymphoblastic leukemia (ALL) is the most common blood cancer of children and adolescents. Remarkable progress has been made in treating this deadly disease, but many children suffer relapses despite these advances.
- Trial name
- ALL (NCT06783738)
- Testing
- Exercise
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Breast Cancer
Investigation of the Prognostic Value of Patterns of Genomic Alterations or Protein Expression in Patients With Operated Early Breast Cancer
This study retrospectively analyze tumor samples and clinical data from Greek women with operable breast cancer of intermediate or high-risk of relapse who participated in HeCOG adjuvant studies.
- Trial name
- NCT07630558
- Where
- Greece
- Volunteers
- 1,891 people
- Sponsor
- Hellenic Cooperative Oncology Group
Sickle Cell Disease
Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders
The primary objectives of this prospective mixed-method interview study are to use semi-structured interviews in parents of sickle cell disease (SCD) patients to describe parental attitudes of research involving genomic…
- Trial name
- NCT04416178
- Where
- United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Endometriosis, Endometrioma
Genomic Maps of Endometrial Tissues of Patients With Endometriosis and Healthy Controls
Endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year.
- Trial name
- NCT03687398
- Testing
- genetic testing with nanoclonal technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Abnormal Cytology
Oncogenous HPV DNA Integration (Intégration De l'ADN Des HPV Oncogènes)
High-risk human papillomavirus (HR-HPV) are involved in cervical cancer development. Integration of HR-HPV DNA in cellular genomes is considered as a major event in the cervical cancer development.
- Trial name
- IDAHO (NCT02864121)
- Testing
- all patients included in IDAHO study
- Where
- France
- Volunteers
- 407 people
- Sponsor
- CHU de Reims
Natural Pregnancy, Pregnancy, Ovarian
Genomic Imprinting and Assisted Reproductive Technologies
Genomic imprinting, referring to an epigenetic marking resulting in monoallelic gene expression, plays a critical role in development.
- Trial name
- EPIGEN (NCT00773825)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
Investigation of Genomic Alteration in Patients With Luminal A or Luminal B Subtypes
This is a translational study in patients with operated early breast cancer of Luminal A or Luminal B sub types.The Hellenic Cooperative Oncology Group (HeCOG) has designed an observational biomarker-driven study in patients with…
- Trial name
- NCT04403984
- Where
- Greece
- Volunteers
- 750 people
- Sponsor
- Hellenic Cooperative Oncology Group
Neurodevelopmental Disorders and Developmental Abnormalities
Transcriptomic Approach for the Identification and Prioritization of Genome Variants in Neurodevelopmental Disorders With Malformation
Three million persons in France are impacted by rare diseases. Amid the 7000 different diseases which are identified today, neurodevelopmental disorders are the main symptoms found interesting 35 000 birth every years, according…
- Trial name
- ATOMICS (NCT06762678)
- Testing
- RNA sequencing and whole genome sequencing in a trio way
- Where
- 7 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Angers
Solid Tumor, Hematological Malignancy
Bergonie Institut Profiling : Fighting Cancer by Matching Molecular Alterations and Drugs in Early Phase Trials
This is a biology driven, monocentric study designed to identify actionable molecular alterations in cancer patients with advanced disease.
- Trial name
- BIP (NCT02534649)
- Testing
- Newly obtained biopsy and Blood samples collection
- Where
- 7 sites in France
- Volunteers
- 10,000 people
- Sponsor
- Institut Bergonié
Inherited Retinal Dystrophy, Retinitis Pigmentosa
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models
Inherited retinal dystrophies (IRDs), a large group of heterogeneous and rare disorders, may result in irreversible bilateral visual loss and blindness.
- Conditions
- Inherited Retinal Dystrophy, Retinitis Pigmentosa, Macular Dystrophy
- Trial name
- NCT05793515
- Testing
- whole genome sequencing
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Superiore di Sanità
Population Genomic Screening Implementation Best Practices
Facilitating the Implementation of Population-wide Genomic Screening
This is a multi-site hybrid implementation-effectiveness trial that uses a stepped-wedge cluster randomized design to evaluate the impact of the FOCUS toolkit, a multicomponent implementation guide, on improving the…
- Trial name
- FOCUS (NCT07806643)
- Testing
- FOCUS Toolkit Training
- Where
- 7 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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