Clinical trials: Genome
Glioma
MMR/MSI Phenotypes in Prediction of Tumor Vaccine Benefit for Gliomas
Glioblastoma (GBM) is the most malignant primary intracranial tumor with a median survival of about 18 months, and new therapies are urgently needed.
- Trial name
- NCT06043232
- Testing
- DC vaccine
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huashan Hospital
Breast Cancer
Effect of a Fruit- and Chaya-Based Diet on Genomic Instability and Biochemical Markers in Women With Breast Cancer Receiving Chemotherapy
This exploratory, non-randomized clinical study aims to evaluate the potential impact of a diet enriched with fruits and chaya (Cnidoscolus aconitifolius) infusion on genomic instability and selected biochemical parameters in…
- Trial name
- NCT07015294
- Testing
- Fruits and chaya infusion, Conventional diet
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- Anahuac Mayab University
Enchondromatosis
Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing
Background: Ollier disease (OD) and Maffucci syndrome (MS) are rare disorders that increase the risk of cancers in cartilage tissue. These tumors can lead to severe skeletal deformities beginning in childhood.
- Trial name
- NCT06749366
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Irritable Bowel Syndrome, Inflammatory Bowel Disease
Effects of Relaxation Response Mind-body Intervention in Patients With IBS and IBD
In this pilot study, the investigators examined whether a relaxation response mind-body intervention could be effectively delivered to mixed groups of IBS and IBD patients and determined the effects of the intervention on quality…
- Trial name
- NCT02136745
- Testing
- Relaxation Response Mind-Body Intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Gastric Cancer, Metastasis
Genomic Evolution of Metastasis in Gastric Cancer
The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.
- Trial name
- NCT05061082
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Epilepsy; Seizure, Neuromuscular Diseases
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
The "North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing, 2 (NCGENES 2)" study is part of a larger consortium project investigating the clinical utility, or net benefit of an intervention on patient and family…
- Conditions
- Epilepsy; Seizure, Neuromuscular Diseases, Brain Malformation, Intellectual Disability
- Trial name
- NCGENES2 (NCT03548779)
- Testing
- Pre-visit prep, usual care + exome seq
- Where
- 3 sites in United States
- Volunteers
- 548 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction
- Trial name
- CABGGenomics (NCT01258231)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
Encephalopathy, Birth Defect
Clinical Utility of Pediatric Whole Exome Sequencing
The investigator aims to examine the clinical utility of WES, including assessment of a variety of clinical outcomes in undiagnosed pediatric cases.
- Conditions
- Encephalopathy, Birth Defect, Intellectual Disability, Multiple Congenital Anomaly
- Trial name
- NCT03525431
- Testing
- Whole Exome Sequencing
- Where
- 4 sites in United States
- Volunteers
- 529 people
- Sponsor
- University of California, San Francisco
Postoperative Cognitive Dysfunction
Whole Genome Single Nucleotide Polymorphisms in Elderly Patients With Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) presents as a long-lasting decline in cognitive function following surgery. Recognized as an important neuropsychological complication of anesthesia and surgery, POCD occurs…
- Trial name
- GenPOCD (NCT02864173)
- Testing
- Whole genome small nucleotide polymorphism genotyping
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- University Hospital, Basel, Switzerland
Retinoschisis
Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis
This study will explore the causes and eye problems of X-linked juvenile retinoschisis (XLRS), an inherited disease that causes vision loss primarily in young males.
- Trial name
- NCT00055029
- Where
- 2 sites in United States
- Volunteers
- 351 people
- Sponsor
- National Eye Institute (NEI)
Healthy
PCR-Based Detection of Bacterial Agents in Platelet Concentrates and Whole Blood
Using methods of molecular biology bacteria can be detected in blood. In comparison to conventional blood cultures "bacterial DNA" is isolated using a new sample preparation system in platelet apheresis concentrates and in the…
- Trial name
- NCT00482339
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Jena
Prostate Cancer, Prostate Cancer Metastatic
Tumor Genomic Pre-test Counseling Tool for Black or African-American Men With Prostate Cancer
The overall goal of the study is to improve equitable delivery of pre-Tumor genetic testing (TGT) counseling tool for Black or African American men with metastatic prostate cancer and evaluating the tool for implementation.
- Trial name
- NCT06171139
- Testing
- Counseling Tool, Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Francisco
Keloid
Keloid Tissue Bank
Much progress in treatment of various tumors has been made in the laboratory and the results have been brought back to the patients, i.e. from bench to bedside.
- Trial name
- NCT01425437
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Tirgan, Michael H., M.D.
Carcinoma, Non-small Cell Lung
Genomic Profiling in Previously Untreated Metastatic Non-small Cell Lung Cancer
Overall survival rates for patients with metastatic NSCLC are poor utilizing conventional cytotoxic chemotherapy approaches. However, a subset of patients harbor genomic driver mutations, which when targeted with specific…
- Trial name
- NCT02671045
- Testing
- Genomic profile by FoundationOne, Genomic profile by other methods
- Where
- United States
- Volunteers
- 649 people
- Sponsor
- Cota Inc.
Unspecified Adult Solid Tumor, Protocol Specific
Genomic Profiling in Recommending Treatment for Patients With Metastatic Solid Tumors
This research trial studies using genomic profiling to recommend anticancer treatment to patients with cancer that has spread beyond the original site of the tumor (metastatic cancer).
- Trial name
- NCT02215928
- Testing
- mutation analysis, cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Fetal Structural Anomalies
Prenatal Genetic Diagnosis by Genomic Sequencing
This study is evaluating the impact of prenatal sequencing on the management of fetuses with ultrasound abnormalities. The hypothesis is that a significant subset of fetal abnormalities have a genetic cause that can be identified…
- Trial name
- PrenatalSEQ (NCT03936101)
- Testing
- Prenatal Genomic Sequencing
- Where
- 5 sites in United States
- Volunteers
- 1,097 people, healthy volunteers welcome
- Sponsor
- Columbia University
Intellectual Disability, Autism
Enhancing Genomic Laboratory Reports to Enhance Communication and Empower Patients
Current lab reports are designed to communicate results from the laboratory to the provider; they are not designed to be accessible to patients.
- Conditions
- Intellectual Disability, Autism, Multiple Congenital Anomalies
- Trial name
- NCT02504502
- Testing
- enhanced genomic report
- Volunteers
- 52 people
- Sponsor
- Geisinger Clinic
Lung Cancer, Precancerous Condition
Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol
RATIONALE: Studying the genes expressed in samples of blood and lung fluid in the laboratory from patients receiving budesonide and formoterol may help doctors learn more about the effect of budesonide and formoterol on gene…
- Trial name
- NCT00569712
- Testing
- budesonide/formoterol fumarate dihydrate inhalation aerosol, DNA methylation analysis, comparative genomic hybridization
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- British Columbia Cancer Agency
Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
This clinical trial is looking at a drug called atezolizumab. Atezolizumab is approved as standard of care treatment for adult patients with urothelial cancer, non-small cell lung cancer, extensive-stage small cell lung cancer…
- Conditions
- Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT05770102)
- Testing
- Atezolizumab
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Cancer
Evaluation of a Decision Aid for Incidental Genomic Findings
Health care providers (HCP) are increasingly using genomic sequencing (GS) to target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases.
- Trial name
- NCT03244202
- Testing
- Decision Aid Plus Counselling, Genetic Counselling Only
- Where
- 2 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Unity Health Toronto
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.