Clinical trials: Genome
Breast Cancer
"Observational, Retrospective and Prospective, Non-interventional, Multicentre on the Use of Genomic Testing in the Management of Early Stage HR+/HER2- Breast Cancer"
The study aims to establish an Italian registry for the implementation of the use of genomic tests in patients with HR +/HER2- breast cancer at intermediate risk of recurrence after the entry into force of the Ministerial Decree…
- Trial name
- GIM29-GIMOMIC (NCT06871501)
- Where
- 25 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Consorzio Oncotech
Prostate Cancer
Exploring Genomic, Proteomic and Dosimetric Determinants of Late Toxicity After Three Dimensional Conformal Radiotherapy (RT) for Prostate Cancer
Prostate cancer is the most common malignancy in males, and radiotherapy is a commonly chosen treatment option for patients with localized disease.
- Trial name
- NCT00122265
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- AHS Cancer Control Alberta
Rheumatoid Arthritis
A Study of Immune Cells in Patients With Rheumatoid Arthritis During Different Types of Anti-TNF Alpha Treatments (Study P05521)
This 14-week study will observe the gene expression of certain immune cells in patients with rheumatoid arthritis who receive etanercept, infliximab, and adalimumab.
- Trial name
- NCT00724672
- Testing
- etanercept, infliximab, adalimumab
- Sponsor
- Merck Sharp & Dohme LLC
Diminished Ovarian Reserve
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve
The study aims to explore the genetic pathogenesis of diminished ovarian reserve via whole-genome sequencing technology in Chinese women.
- Trial name
- NCT04711772
- Testing
- whole-genome sequencing
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pigmentary; Dermatosis
Genomic Study of Cutis Tricolor
It's a study on Syndromic or Isolated Cutis Tricolor and had as main goal to identify the associated gene to the disease thanks to genetic analysis on minors patients and their parents reach by cutis Tricolor or not.
- Trial name
- Cutis Tricolor (NCT06073171)
- Testing
- Blood sample, Cutaneous biopsy, High troughput sequencing of human's exome
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Multiple Myeloma
Optical Genome Mapping in Characterization of Multiple Myeloma
The current cytogenetic characterization of Multiple Myeloma (including chromosome and gene abnormalities identification in abnormal plasma cells) encounters some limitations.
- Trial name
- MYELOPTIC (NCT05786105)
- Testing
- Bone Marrow samples collection
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Chronic Hepatitis B
Exploring the Genome-wide Association Study of the Population With Clinical Cure Advantage in the Treatment of Chronic Hepatitis B With Long-acting Interferon
This study is a real-world case-control study conducted, with 120 CHB patients who received continuous treatment with PEG-IFN-α for more than 24 weeks as study subjects.
- Trial name
- NCT06696664
- Testing
- PEG-IFN-α
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Minghui Li
Myelodysplastic Syndrome
A Clinical Trial of Decitabine in Patients With Myelodysplastic Syndrome
The purpose of this study was to determine which of the doses of decitabine maximizes genomic demethylation in patients with Myelodysplastic Syndrome (MDS).
- Trial name
- NCT00282399
- Testing
- Subcutaneous Decitabine
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Eisai Inc.
Pancreas Adenocarcinoma, Cachexia
Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma
A major complication of pancreatic adenocarcinoma (PDAC) is cancer cachexia (CC) which is a complex syndrome characterized by skeletal muscle mass loss (with or without loss of fat mass) and progressive functional impairment not…
- Trial name
- NCT05376592
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Colon Cancer, Breast Cancer
An Integrated Genomic Approach to Assess Genetic Risk and Drug Sensitivity
National multicenter prospective study, involving the enrollment of approximately 1,500 patients with ovarian cancer, 1,500 patients with breast cancer, and 1,000 patients with colorectal cancer.
- Conditions
- Colon Cancer, Breast Cancer, Ovarian Cancer, Genetic Risk Factors
- Trial name
- GERSOM (NCT07555639)
- Testing
- Genomic profile
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Biliary Tract Cancer
Molecular Profiling of Advanced Biliary Tract Cancers
Biliary tract cancer (BTC) accounts for <1% of all cancers, but remains a highly fatal malignancy. Surgical resection is the only hope for cure, but most patients present with advanced disease when curative-intent surgery is not…
- Trial name
- COMPASS-B-MUHC (NCT04318834)
- Testing
- Tumour and germline molecular profiling
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neuroblastoma
A Pilot Study on ALK Gene Mutations in Neuroblastoma
Neuroblastoma (NB) originates from the sympathetic nervous system and is one of the most common cancers in infants and children.
- Trial name
- NCT01986595
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Prostate Cancer
Integrated Genomic Prostate Score With MRI Targeted Prostate Biopsies
Background: Prostate cancer is one of the most common cancers in men. For some men, their cancer is monitored. Others have surgery to remove the prostate. Focal therapy is another treatment option.
- Trial name
- NCT04541030
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- National Cancer Institute (NCI)
Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood.
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis, Tonsil Disorder
- Trial name
- NCT05656365
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non Small Cell Lung Cancer
Study Using a Genomic Predictor of Platinum Resistance to Guide Therapy in Stage IIIB/IV Non-Small Cell Lung Cancer
In this trial, subjects with chemo-naive advanced non-small cell lung cancer (NSCLC) were assigned to chemotherapy using a genomic-based predictor for platinum sensitivity.
- Trial name
- TOP0602 (NCT00509366)
- Testing
- Cisplatin & Gemcitabine, Cisplatin & Pemetrexed, Docetaxel & Gemcitabine
- Where
- 8 sites in United States
- Volunteers
- 101 people
- Sponsor
- Duke University
Fetal Growth Retardation
Fetal Genome Profiling Via Trophoblast Cells
The objective of this study is to utilize trophoblast cells accumulating in the endocervical canal at the beginning of pregnancy for non-invasive prenatal testing.
- Trial name
- NCT03832634
- Testing
- Fetal Genome Profiling.
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Longitudinal, Genomic Stability
Epidemiology and Overtime Genomic Evolution of Klebsiella Pneumoniae and Enterobacter Cloacae Complex (ECC) in Stools of ICU's Patients
Infections are one of the major threats for inpatients, even more for patients hospitalized in intensive care units (ICUs). They are responsible for an important increase of morbidity and mortality rates as well as a burst of…
- Conditions
- Longitudinal, Genomic Stability, Klebsiella Infections, Enterobacter Cloacae Infection
- Trial name
- NormandyKlebs (NCT07744321)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Acute Lymphoblastic Leukemia, Hodgkin Lymphoma
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
This study examines the impact of social and genetic factors on outcomes in adolescent and young adult (AYA) cancer survivors of Hodgkin or non-Hodgkin lymphoma or leukemia.
- Conditions
- Acute Lymphoblastic Leukemia, Hodgkin Lymphoma, Non-Hodgkin Lymphoma
- Trial name
- NCT06002828
- Testing
- Non-Interventional Study
- Where
- 507 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Prostate Cancer, Renal Cell Carcinoma (RCC)
Characterizing the Genomic Landscape of Cancer in Native American Populations (NAT-Geno)
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prespecified cancers of interest.
- Trial name
- NCT06960798
- Testing
- Bio-specimen Collection, Blood Draw
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Oklahoma
Breast Cancer Female
MEND 2: Making Treatment Decisions Using Genomic Testing
Clinical guidelines for women with early stage breast cancer integrate genomic tumor profiling tests such as the Oncotype DX Recurrence Score to refine recurrence estimates and systemic therapy selection when combined with…
- Trial name
- MEND2 (NCT03183050)
- Testing
- Question Prompt List
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Georgetown University
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