Clinical trials: Genome
Rare Diseases, Genetic Disease
The VetSeq Study: a Pilot Study of Genome Sequencing in Veteran Care
The VetSeq Study is a pilot intervention study exploring the feasibility of integrating genome sequencing into clinical care at the VA Boston Healthcare System.
- Trial name
- NCT03380819
- Testing
- Genome sequencing
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Boston Healthcare System
Endometrial Neoplasms, TP53 Gene Mutation
Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma
The objective is to understand the relationship between TP53 mutation, MSS and chromosome instability in endometrial cancer and the effect on clinical prognosis.We will collect a small amount of tumor tissue samples.
- Conditions
- Endometrial Neoplasms, TP53 Gene Mutation, Chromosomal Instability, Microsatellite Stable Endometrial Carcinoma
- Trial name
- NCT06521684
- Volunteers
- 110 people
- Sponsor
- Peking Union Medical College Hospital
Pediatric Solid Tumors
Clinical and Therapeutic Impact of Large Genomic Studies at Diagnosis in Pediatric Solid Cancers
Pediatric solid tumors with an unfavorable prognosis remain a public health issue due to their morbidity and mortality and their rapidly evolving profile. They are defined by an expected overall survival of < 30%.
- Trial name
- CS-PEDIA (NCT06171971)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Strasbourg, France
Metastatic Prostate Cancer
Feasibility and Impact of Liquid Biopsy Genomic Profiling on Treatment Patients With Metastatic Prostate Cancer in Spain (SOLTI-2102)
HOPE Prostate is an observational study that aims at promoting research against metastatic prostate cancer by means of collective research led by patients (patient-centric trial).
- Trial name
- HOPE-PROSTATE (NCT05885009)
- Testing
- Liquid Biopsy, Archival Tumor DNA sequencing
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- SOLTI Breast Cancer Research Group
Colorectal Cancer
Zanzalintinib Alone or in Combination With Pembrolizumab and Berahyaluronidase Alfa in Participants With Colorectal Cancer With Molecular Residual Disease
The primary objective of this study is to evaluate the effectiveness of zanzalintinib + Pembrolizumab (+) berahyaluronidase alfa and zanzalintinib alone compared with placebo.
- Trial name
- STELLAR-316 (NCT07750158)
- Testing
- Zanzalintinib, Pembrolizumab (+) Berahyaluronidase alfa
- Where
- 13 sites in United States
- Volunteers
- 600 people
- Sponsor
- Exelixis
Neurodevelopmental Disorders, Intellectual Developmental Disorder
High Depth Exome Sequencing on DNA From a Salivary Sample by Mouth Smear.
Despite technological advances, a genetic etiology has been identified in only about 50% to 60% of patients with Neurodevelopmental disorders (NDDs), with a higher diagnostic yield in the syndromic NDD and IDD subgroups.
- Trial name
- SEPASA (NCT07492199)
- Testing
- genetic
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Psychosis
Multiomic Diagnostics in Youth With Psychosis
Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic…
- Trial name
- NCT05457140
- Testing
- Genetic: Genomic sequencing and molecular diagnostic results, if any., Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rady Pediatric Genomics & Systems Medicine Institute
Tuberculosis
Genome Sequencing of Multidrug Resistant Tuberculosis (MDR TB) in Sputum
Drug resistant tuberculosis is a growing problem world wide. The current methods for diagnosis are time consuming and may delay diagnosis and treatment for many weeks.
- Trial name
- MDRTB01 (NCT02245347)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's Healthcare NHS Trust
Seemingly Healthy, Genetic Predisposition to Disease
Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts
The PopSeq Project is a prospective cohort study that will develop and implement a genomic return of results (gRoR) process in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts and explore associated medical…
- Trial name
- PopSeq (NCT04196374)
- Testing
- Genomic Sequencing
- Where
- 2 sites in United States
- Volunteers
- 7,603 people
- Sponsor
- Brigham and Women's Hospital
Malignant Solid Tumor
A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.
This trial is a multicenter, open-label, biology driven, phase II study using a sequential Bayesian design, aiming to assess the efficacy and safety of different Matched Targeted Therapy (MTT) in independent and parallel cohorts…
- Trial name
- MegaMOST (NCT04116541)
- Testing
- HDM201, Ribociclib, Cabozantinib
- Where
- 13 sites in France
- Volunteers
- 455 people
- Sponsor
- Centre Leon Berard
Retroperitoneal Liposarcoma, Soft Tissue Sarcoma
Genomic Risk in Retroperitoneal Sarcoma
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease.
- Trial name
- NCT06436846
- Testing
- Biospecimen sample collection during standard-of-care surgery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Rare Diseases, Genetic Predisposition to Disease
Genome-based Management of Patients in Precision Medicine (Ge-Med) Towards a Genomic Health Program
The GE-MED APPROACH project will enroll patients (n = appr. 12.000) with unclear molecular cause of the disease, suspected genetic cause of the disease without detailed molecular analysis like Whole Exome Sequencing (WES).
- Trial name
- GE-MED (NCT04760522)
- Testing
- WGS Diagnostic: Blood take for genetic diagnostic
- Where
- Germany
- Volunteers
- 12,000 people
- Sponsor
- University Hospital Tuebingen
Prenatal, Genome-wide High Throughput Sequencing
ANDDI-PRENATOME - Feasibility Study for a " Fast " Pangenomic High Throughput Sequencing Analysis in Prenatal Diagnosis
Prenatal diagnosis of genetic diseases is a real medical challenge. The discovery of antenatal abnormalities on ultrasound is frequent (5 to 10% of pregnancies), and when an abnormalities is seen on ultrasound, it raises the…
- Trial name
- AnddiPrenatome (NCT03964441)
- Testing
- Invasive fetal sampling, blood sampling of mother and father, blood sampling from the mother to recover the circulating cell free fetal DNA, Parent interviews (optional organizational study)
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Thyroid Cancer, Non-Cancer Thyroid Disease
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Ukraine Following the Chernobyl Accident
The nuclear power plant accident at Chornobyl released large quantities of Iodine-131 and other radioisotopes of iodine in the atmosphere, contaminating thousands of square kilometers and exposing millions of people.
- Conditions
- Thyroid Cancer, Non-Cancer Thyroid Disease, Non Thyroid Cancer
- Trial name
- NCT00341094
- Where
- Ukraine
- Volunteers
- 23,143 people
- Sponsor
- National Cancer Institute (NCI)
NSCLC
An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network
A Multi-centre Observational Study to Evaluate the Clinical Utility of Returning Genomic Aberration results Using the Oncomine Precision Assay in Advanced or Metastatic Non-Small Cell Lung Cancer Patients within the Exactis…
- Trial name
- NCT04564079
- Where
- 6 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Exactis Innovation
Pharmacogenomics, Medication Therapy Management
A Pharmacist Implemented Pharmacogenomics Service in the Program of All-inclusive Care for the Elderly
The aim of this study is to evaluate and describe the feasibility of implementing a pharmacist-led pharmacogenomics service for the Program of All-inclusive Care for the Elderly (PACE), a community-based practice setting.
- Trial name
- PACE (NCT03257605)
- Volunteers
- 296 people
- Sponsor
- Tabula Rasa HealthCare
Viral Diseases
Identification of Viruses Associated With Diseases of Unknown Cause
This study will try to identify new or known viruses responsible for diseases or conditions of unknown cause. Viruses are an important cause of illness.
- Trial name
- NCT00359268
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Advanced Solid Tumors Cancer, MSI-H Cancer
A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.
The goal of this clinical trial is to learn if NDI-219216 is safe for patients, and if NDI-219216 might be a possible treatment for advanced solid tumors in the later phases of the study.
- Trial name
- NCT06898450
- Testing
- NDI-219216
- Where
- 22 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Nimbus Wadjet, Inc.
Bipolar Disorder
NeuroPsyBiT-BD Omics: Genomic & Epigenomic Biobank of Bipolar Disorder
Brief Summary The goal of this observational study is to establish a comprehensive biobank and phenotypic data repository for patients diagnosed with bipolar disorder in Türkiye.
- Trial name
- NeuroPsyBiT-BD (NCT07173842)
- Testing
- Biobanking and Phenotypic Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Selçuk State Hospital
Non-Small Cell Lung Cancer, Small Cell Lung Cancer
Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors
Background: Lung cancer is the leading cause of cancer-related death worldwide. It causes more than one million deaths every year.
- Conditions
- Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors
- Trial name
- NCT02146170
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Cancer Institute (NCI)
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