Clinical trials: Genome
Molecular Classification of HNSCC
HNSCC Immuno-genomics Project
For locally advanced and recurrent / metastatic head \& neck squamous cell carcinoma (HNSCC), the is an unmet need for the development of efficient treatment combinations, particularly with immune checkpoint inhibitors.
- Trial name
- NCT06725342
- Testing
- Combined DNA/RNA sequencing on clinical FFPE material (technically challenging; innovative); immuno-genomics test.
- Volunteers
- 401 people
- Sponsor
- Hellenic Cooperative Oncology Group
Colorectal Cancer, Microsatellite Instability
National Cohort of Colorectal Cancers With Microsatellite Instability
The three main pathways of colorectal carcinogenesis are chromosomal instability, microsatellite instability (MSI) (15% of colorectal cancers =CRCs) and CpG island methylator phenotype (CIMP).
- Trial name
- NCT05511688
- Where
- 14 sites in France
- Volunteers
- 637 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Intellectual Disabilities, Congenital Anomaly
Genome Medical Sequencing for Gene Discovery
Background: A number of rare inherited diseases affect only a few patients, and the genetic causes of these conditions remain unknown.
- Conditions
- Intellectual Disabilities, Congenital Anomaly, Rare Disorders
- Trial name
- NCT01087320
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Oligospermia
Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men
This study will analyse the sperm global methylation status of 62 infertile men before assisted reproductive techniques. Some of these patients (20%) present hypomethylation of H19 locus.
- Trial name
- METHYLHOMME (NCT01239186)
- Testing
- methylation analyses on spermatozoa from infertile men
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bladder Cancer, Genomic Instability
Bladder Cancer and Neoadjuvant Chemotherapy Efficiency Before Cystectomy
This study will allow the investigators to better assess the efficiency of neoadjuvant chemotherapy before cystectomy by training a predictive model on different patient cohorts with bladder cancer.
- Trial name
- SELECT (NCT06294054)
- Testing
- neoadjuvant chemotherapy with cisplatine
- Where
- 7 sites in France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Rouen
This Study Aims to Reveal the Effectiveness, Accuracy, and Feasibility in Bile
Study to Assess the Feasibility in Bile cfDNA of Resectable Biliary Tract Carcinomas
This study intends to use Onconscreen plus 520 Panel (Burning Rock, China) to conduct NGS testing in matched tissue, blood , and bile samples of patients with Resectable Biliary Tract Carcinomas（BTC）.
- Trial name
- NCT05783973
- Testing
- Next generation sequencing
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Parkinson's Disease
Combined Genome and RNA Sequencing for Genetic Diagnosis of Parkinsonism
Despite the increasing availability and advances in the analysis of high-throughput DNA sequencing, the majority of patients with early-onset or familial parkinsonism remain without a molecular diagnosis.
- Trial name
- ParkOmic (NCT06576713)
- Testing
- Combiner whole genome and RNA sequencing
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetes Mellitus, Diabetic Nephropathy
Study of Genome-associated Mechanisms of Diabetic Nephropathy and Evaluation of Nephroprotective Therapy in Patients With Type 2 Diabetes Mellitus in the Kazakh Population
The incidence of diabetes remains a serious global health issue, demanding close attention and the development of comprehensive strategies for prevention, early diagnosis, and effective treatment .
- Trial name
- NCT07038213
- Testing
- glycation genes, beta 2 microglobulin
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- Astana Medical University
Fever, Neutropenia
Fever and Neutropenia in Pediatric Oncology Patients
It is possible to distinguish between pediatric oncology patients who are at high or low risk for serious infection during periods of fever and treatment related neutropenia based on clinical parameters.
- Trial name
- NCT03768869
- Testing
- Low Risk: Oupatient Management, Low Risk: Inpatient Management, High Risk: Inpatient Management
- Where
- United States
- Sponsor
- University of Colorado, Denver
Microsatellite-instability (MSI) High Colorectal Cancer (CRC), Endometrial Cancer
Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers
The purpose of this study was to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in participants with certain cancers. This study was conducted in 2 phases, Phase 1 and Phase 2.
- Conditions
- Microsatellite-instability (MSI) High Colorectal Cancer (CRC), Endometrial Cancer, Head and Neck Cancer, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT02178722
- Testing
- MK-3475, INCB024360
- Where
- 24 sites in United States
- Volunteers
- 444 people
- Sponsor
- Incyte Corporation
Head and Neck Squamous Cell Carcinoma
The Head and Neck Tumor Biobank
The purpose of the biobank is to enable future genomic based research on this Head and Neck Cancer patient population. The investigators will try to identify tumor factors that will predict cancer-related outcome in order to…
- Trial name
- NCT01644786
- Where
- Netherlands
- Volunteers
- 419 people
- Sponsor
- Maastricht Radiation Oncology
Diarrhea, Infantile, Enteropathy
Whole Genome Sequencing Versus Whole Exome Sequencing for Congenital Diarrhea and Enteropahty
This study will seek to determine if whole genome sequencing (WGS) improves diagnostic rates, and outcomes for congenital diarrhea and enteropathy (CODE) patients.
- Trial name
- NCT04528303
- Testing
- Whole genome sequencing, Whole exome sequencing
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Children's Hospital of Fudan University
Breast Cancer
Adjuvant Systemic Treatment for (ER)-Positive HER2-negative Breast Carcinoma in Women Over 70 According to Genomic Grade (GG): Chemotherapy + Endocrine Treatment Versus Endocrine Treatment
The purpose of the study is to evaluate the benefit of adjuvant chemotherapy on overall survival for elderly patients with breast cancer, in a sub group with a high risk of relapse according to Genomic Grade test.
- Trial name
- ASTER 70s (NCT01564056)
- Testing
- HORMONOTHERAPY, CHEMOTHERAPY then HORMONOTHERAPY
- Where
- 84 sites in Belgium, France
- Volunteers
- 1,989 people
- Sponsor
- UNICANCER
Breast Cancer
Study of Radiation Exposure and Bilateral Breast Cancer
This study is being done to find out what factors may be related to the risk of getting a second breast cancer among women who already have breast cancer in one breast.
- Trial name
- NCT00903591
- Testing
- questionaire, blood or saliva sample
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 1,699 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
COPD, Chronic Obstructive Pulmonary Disease
An Integrative Genomic Approach to Solve tHe Puzzle of sevERe earLy-Onset COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by a chronic airflow limitation associated with an abnormal inflammatory response of the airways to inhaled noxious particles or gases.
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Severe Early-Onset COPD, SEO-COPD
- Trial name
- SHERLOCk (NCT04263961)
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Tuberculosis, Multidrug-Resistant
The Individualized M(X) Drug-resistant TB Treatment Strategy Study
This is a randomized controlled clinical trial comparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis…
- Trial name
- InDEX (NCT03237182)
- Testing
- Individualized TB treatment with multiple drugs, Standardized TB treatment with multiple drugs
- Where
- South Africa
- Volunteers
- 205 people
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
Advanced Malignant Neoplasm, ALK Fusion Protein Expression
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
This phase II trial studies how well brigatinib works in treating patients with ALK and ROS1 gene alterations and solid cancers that have spread to nearby tissue and lymph nodes or other places in the body.
- Conditions
- Advanced Malignant Neoplasm, ALK Fusion Protein Expression, ALK Gene Amplification, ALK Gene Mutation
- Trial name
- NCT03868423
- Testing
- Brigatinib, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Sponsor
- Sameek Roychowdhury
COVID-19, Molecular Sequence Variation
COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations
This is a tertiary care hospital-based prospective molecular epidemiology study in Montreal, Canada. When nosocomial transmission was suspected by local infection control teams' investigations, SARS-CoV-2 viral genomic sequencing…
- Conditions
- COVID-19, Molecular Sequence Variation, Nosocomial Infection
- Trial name
- NOSO-COVID (NCT05411562)
- Testing
- SARS-CoV-2 genomic sequencing
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Solid Tumor Malignancies, Metastatic Cancer
PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival
This is a hybrid decentralized, single-arm, interventional study designed to evaluate the impact of precision medicine navigation and reflexive expert review of next-generation sequencing (NGS) for patients with stage IV solid…
- Conditions
- Solid Tumor Malignancies, Metastatic Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- PROGRESS (NCT06896162)
- Testing
- Expert Review, Blood or tissue samples collection., The Precision Oncology Navigation
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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