Clinical trials: Genome
Burn Pit Exposure, Airborne Hazard Exposure
Project PHOENIX: Molecular Signatures of Burn Pit Exposure
Project PHOENIX is an observational clinical research study designed to characterize molecular, genomic, cellular, and functional features in blood specimens from former U.S.
- Conditions
- Burn Pit Exposure, Airborne Hazard Exposure, Veteran Health, Deployment-Related Toxic Exposure
- Trial name
- PHOENIX (NCT07562243)
- Testing
- Prior Burn Pit Exposure, No Known Burn Pit Exposure
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Creative Medical Technology Holdings Inc
Congenital Hip Dislocation
Research for Genetic Factors Involved in Congenital Dislocation of Hip: Genome-wide Association Study in Grand West France
The main objective is to identify the genes involved in congenital dislocation of the hip. The secondary objectives are to measure the association between mechanical risk factors and congenital dislocation of hip and study the…
- Trial name
- GENETHIP (NCT02900482)
- Testing
- Sampling saliva
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Brest
Normal Physiology
Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids
Background: The immune system defends the body against bacteria and other harmful invaders. But it can overact and attack healthy cells by mistake.
- Trial name
- NCT02798523
- Testing
- Methylprednisolone sodium succinate(Solu-Medrol), Topical methylprednisolone (Advantan emulsion 0 /1%)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Genetic Predisposition
Next Generation to Identify Genetic Causes of Disease in Patients Participating in NICHD Clinical Protocols
Background: The purpose of this study is to identify changes in genes that cause human diseases. We would like to obtain some of you or your child s DNA and test for changes in genes that may contribute to a disease in you or…
- Trial name
- NCT01375543
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Embryo Aneuploidies, Implantation Rates
Preimplantation Genetic Screening (PGS) in Advanced Female Age and Male Severe Factor
Preimplantation Genetic Screening (PGS) is used for the selection of chromosomally normal embryos before the transfer in IVF treatments in many cases.
- Conditions
- Embryo Aneuploidies, Implantation Rates, Infertility
- Trial name
- NCT01571076
- Testing
- PGS, Prolonged culture
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Igenomix
Breast Cancer Female
Biological Characteristics of Older Women (> 70 Years) With ER Positive, HER2 Negative Early Breast Cancer
This study is investigating the biological characteristics of early oestrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer (BC) in older woman (aged > 70 years) who were treated…
- Trial name
- BOLD-70 (NCT05734950)
- Testing
- Translational study
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Enteric Fever, Acute Febrile Illness
Transcriptomic Responses for the Identification of Pathogens
Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions.
- Conditions
- Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever
- Trial name
- TRiP (NCT04878549)
- Testing
- 5-gene transcription signature
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Ulcerative Colitis, Healthy
Genome Analysis Across Populations in Inflammatory Bowel Disease
Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD within affected populations.
- Conditions
- Ulcerative Colitis, Healthy, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- NCT06042387
- Testing
- Blood or saliva sample collection
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Malignant Neoplasms, Hereditary Neoplastic Syndromes
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease
Selected individuals suspected of having or with prior biopsy proof of malignant disease will be seen in the Urologic Oncology Branch, NCI.
- Conditions
- Malignant Neoplasms, Hereditary Neoplastic Syndromes, Kidney Cancer, Renal Cancer
- Trial name
- NCT00026884
- Where
- United States
- Volunteers
- 5,950 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Genodermatosis, Rare Genetic Disease With Cutaneous Expression
Method of Genetic Analysis in Genodermatoses
The goal of the study is to develop a method of genetic diagnosis in two stages, by mendelioma then by genome and transcriptome on fibroblast culture, in genodermatoses and rare diseases with cutaneous expression in the child.
- Trial name
- GENODERM (NCT03873285)
- Testing
- Genetic diagnostic by mendeliome or genome
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Queen Fabiola Children's University Hospital
Sepsis, Infections
Hypervirulent Amoxicillin-Susceptible Klebsiella Pneumoniae CC66, France, 2016-2023
"Klebsiella pneumoniae is considered intrinsically resistant to ampicillin because of the chromosomal blaSHV β-lactamase. However, amoxicillin-susceptible isolates have been sporadically reported.
- Trial name
- NCT07598006
- Testing
- Bacterial species identification by Whole Genome sequencing
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Hepatocellular Carcinoma
Identification and Prognostic Value of Key Genes in Hepatocellular Carcinoma
To explore the key genes of human and mouse hepatocellular carcinoma, identify the key genes and prognostic markers, and develop small molecule drugs targeting the key genes to treat hepatocellular carcinoma.
- Trial name
- NCT05759858
- Testing
- None of intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontal Disease "Unrecognized Condition"
Design of a Protocol for Obtaining Genomic DNA From Saliva
Objective The aim of this study was to test a protocol for the extraction of high quality genomic DNA from saliva samples obtained with mouthwash and taken from patients with periodontal disease.
- Trial name
- DPOGDNAS (NCT02523326)
- Testing
- saliva samples obtained with mouthwash
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Centro Interdisciplinario de Ciencias de la Salud Unidad Santo Tomás
Pigmentary; Dermatosis
Genomic Study of Cutis Tricolor
It's a study on Syndromic or Isolated Cutis Tricolor and had as main goal to identify the associated gene to the disease thanks to genetic analysis on minors patients and their parents reach by cutis Tricolor or not.
- Trial name
- Cutis Tricolor (NCT06073171)
- Testing
- Blood sample, Cutaneous biopsy, High troughput sequencing of human's exome
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Lymphoma, Chemotherapy-induced Neutropenia
Danish Elder Lymphoma Patient Hematopoietic Investigation
Every year approximately 300 Danish patients die from lymphoma. The median age at diagnosis is 70 years. Lymphoma can be efficiently treated with chemotherapy, and potentially cured.
- Conditions
- Lymphoma, Chemotherapy-induced Neutropenia, Chemotherapy-Related Leukemia, Chemotherapeutic Toxicity
- Trial name
- DELPHI (NCT05245487)
- Testing
- DNA repair gene mutation analysis
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Metastatic Pancreatic Cancer, Advanced Pancreatic Cancer
Profiling Program of Advanced/Metastatic Pancreatic Cancer Patients
The proposal is to implement a molecular screening program for advanced/metastatic pancreatic cancer patients before the initiation of 1st line treatment in order to allow a better selection of patients for rationale personalized…
- Trial name
- NCT05380414
- Testing
- Tumor samples (archival FFPE and optional de novo biopsy) and blood samples
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Centre Leon Berard
Atopic Dermatitis, Eczema
Using a Telemedicine Approach in a Genome-wide Association Study of Atopic Dermatitis - Searching for Novel Biomarkers in Clinically Relevant Phenotypes
Atopic eczema is a common skin disorder affecting at least 2-3% of the western population. Atopic eczema cannot be cured and therefore treatment aims to alleviate the symptoms of the disease.
- Conditions
- Atopic Dermatitis, Eczema, DNA
- Trial name
- NCT04965233
- Testing
- DNA reports, Information reports
- Where
- 2 sites in United States, Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Studies&Me
Salivary Gland Cancer, Metastatic
A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes
This is a study of select drug therapies in patients with salivary gland cancer. The study has two phases: a molecular profiling phase (phase 1) and a treatment phase (phase 2).
- Conditions
- Salivary Gland Cancer, Metastatic, Advanced, Recurrent
- Trial name
- NCT02069730
- Testing
- Selinexor, EGFR or HER2 Inhibitor, FGFR Inhibitor
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- University Health Network, Toronto
Recurrent Gastric Cancer
A Study of Genomic-guided 'Standard-of-care' Chemotherapy for in Advanced Gastric Cancer Patients
This is an open, non-randomized, multicenter Phase II study evaluating cisplatin plus TS-1 or oxaliplatin plus TS-1 as first-line therapy in predicted 'responder' to platinum and fluoropyrimidine.
- Trial name
- 3G (NCT01100801)
- Testing
- TS-1 with cisplatin, TS-1 with oxaliplatin
- Where
- Singapore
- Volunteers
- 90 people
- Sponsor
- National University Hospital, Singapore
Amyotrophic Lateral Sclerosis, Movement Disorders
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information that are made available to…
- Conditions
- Amyotrophic Lateral Sclerosis, Movement Disorders, Degenerative Disorder, Motor Neuron Disease
- Trial name
- TALSLB (NCT05137665)
- Where
- 12 sites in United States, Colombia and 1 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Target ALS Foundation, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.