Clinical trials: Genome
Chronic Kidney Disease(CKD), Genetic Kidney Disease
Genomic First Testing in Chronic Kidney Disease
This multi-center study examines the role of genetic testing in patients with chronic kidney disease (CKD) who are identified as being at risk for genetic kidney disease, based on Ontario Health's Provincial Genetic Program…
- Trial name
- NCT06794567
- Testing
- Genetic Testing
- Where
- Canada
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Dervla Connaughton
Recurrent Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer
This research trial studies comprehensive genomic analysis in tissue samples from patients with non-small cell lung cancer that has come back or is stage IV.
- Trial name
- NCT02178163
- Testing
- cytology specimen collection procedure, laboratory biomarker analysis
- Where
- 11 sites in United States
- Volunteers
- 619 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Myocardial Infarction, Cerebrovascular Accident
Analyzing Gene Regions That May Interact With the Effectiveness of High Blood Pressure Drugs
High blood pressure is one of the most common health problems in the United States. There are many drug treatment options for high blood pressure, but these medications are not always effective.
- Conditions
- Myocardial Infarction, Cerebrovascular Accident, Death, Sudden, Cardiac
- Trial name
- NCT00573092
- Where
- United States
- Sponsor
- University of Washington
Neurodevelopmental Disorders, Intellectual Developmental Disorder
High Depth Exome Sequencing on DNA From a Salivary Sample by Mouth Smear.
Despite technological advances, a genetic etiology has been identified in only about 50% to 60% of patients with Neurodevelopmental disorders (NDDs), with a higher diagnostic yield in the syndromic NDD and IDD subgroups.
- Trial name
- SEPASA (NCT07492199)
- Testing
- genetic
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Alpha 1 Antitrypsin Deficiency, AATD
Genomic Research in Alpha-1 Antitrypsin Deficiency
This project is designed to examine the interaction between the microflora in the lower airway and the concentration of a serum protein called alpha-1 antitrypsin.
- Trial name
- GRADS Alpha-1 (NCT01832220)
- Where
- 9 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Pittsburgh
Colorectal Medullary Carcinoma
Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study
Medullary carcinoma (MC) is a rare tumor with solid growth pattern without glandular differentiation and constitute less than 1% of colorectal cancer.
- Trial name
- NCT03774862
- Volunteers
- 13 people
- Sponsor
- V.K.V. American Hospital, Istanbul
Leukemia
Genome, Proteome and Tissue Microarray in Childhood Acute Leukemia
We will study gene and protein expression in leukemia cells of children diagnosed with acute leukemia. We hope to identify genes or proteins which can help us grade leukemia at diagnosis in order to: (a) develop better means of…
- Trial name
- NCT01108497
- Testing
- Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Stanford University
Triple Negative Breast Cancer
Pilot Study To Investigate Targetable Metabolic Pathways Sustaining Triple Negative Breast Cancer
The primary objective is to describe and discover new insights into the glucose, amino acid, and lipid metabolic dependencies of TNBC via nuclear magnetic resonance (NMR) spectroscopy analysis of in vivo [1,2-13C] glucose-labeled…
- Trial name
- NCT03457779
- Testing
- Glucose
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Baylor Research Institute
Uveal Melanoma
Comparison Between Fotemustin to Intensive Surveillance in Patients With High Risk Uveal Melanoma
After the local treatment of the primary tumor (protonbeam-therapy, enucleation, external radiotherapy) patients with high risk of metastasis are randomized between: Adjuvant chemotherapy with Fotemustin.
- Trial name
- FOTEADJ (NCT02843386)
- Testing
- Adjuvant chemotherapy by Fotemustin, Intensive surveillance
- Where
- 6 sites in France, Switzerland
- Volunteers
- 302 people
- Sponsor
- Institut Curie
Epithelial Ovarian Cancer, Epithelial Ovarian Tumor of Borderline Malignancy
A Genomic Analysis of Evolution of Epithelia Ovarian Tumors
Epithelial ovarian carcinomatous and borderline components sometimes appeared in one patient. This study aims to analyze the genomic patterns of the carcinomatous and borderline components in the ovarian epithelial tissues.
- Conditions
- Epithelial Ovarian Cancer, Epithelial Ovarian Tumor of Borderline Malignancy, Driving Mutations, Progression-free Survival
- Trial name
- NCT03742388
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lei Li
Sarcoma
GENomic PROfilation for Therapeutic Purposes in SARComas and Molecular Tumor Board (MTB): Retrospective/Prospective Study in Referral Centers
Multicenter noninterventional, translational study, retrospective/prospective designed in order to assess the aptitude to the use of genomic profiling methods for therapeutic purposes and evaluation by the institutional Molecular…
- Trial name
- PROGEN_SARC (NCT06076070)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Regina Elena Cancer Institute
Respiratory Distress Syndrome, Adult
Understanding the Role of Genes and Biomarkers in the Inflammation and Blood Clotting Process in Children With Acute Lung Injury
Acute lung injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition that causes respiratory failure. This study will examine if differences in genes and biomarkers involved in the inflammation and blood…
- Trial name
- PALI (NCT00605527)
- Where
- 5 sites in United States
- Volunteers
- 396 people
- Sponsor
- University of California, San Francisco
Hereditary Erythrocytosis/Idiopathic Erythrocytosis
Genomic Screening for Hereditary Erythrocytosis and Related Diseases
Unexplained polycythemias are rare diseases, and therefore, the collection of data inherent to these diseases will not only improve their characterisation, but also allow stratification according to the risks and the course of…
- Trial name
- GENRED (NCT03263364)
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Axillary Ultrasound
Use of Axillary Ultrasound to Guide Breast Cancer Management in the Genomic Assay Era
The investigators aimed to determine if axillary ultrasound can reliably distinguish between patients with limited or high nodal burden, so that the patients with limited nodal burden can potentially avoid chemotherapy and…
- Trial name
- NCT06038110
- Testing
- axillary ultrasound
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- KK Women's and Children's Hospital
Tumor Genomic Profiling
Cancer Patients Decision Making and Family Communication About Secondary Findings From Tumor Genomic Profiling
The objective of this protocol is to characterize cancer patients' responses to learning their secondary findings arising from tumor genomic profiling, and the process and outcomes of their decisions to communicate these results…
- Trial name
- NCT02713334
- Testing
- survey, semi-structured interview
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Urinary Tract Infections, Sequelae of; Infection
mNGS for Therapy of Urinary Infectious Diseases
Urinary tract infection is a common infectious disease in clinic. Although urinary tract infection can be initially diagnosed by clinical sign and symptom, signs and urine routine, the application of appropriate antibiotic…
- Trial name
- PGS-U-UTI&UC (NCT05624476)
- Testing
- mNGS of urine cell-free DNA
- Volunteers
- 72 people
- Sponsor
- Shanghai Changzheng Hospital
Metastatic Cancer, Advanced Cancer
Real-world Clinical Effectiveness of Whole Genome and Transcriptome Analysis to Guide Advanced Cancer Care
This study aims to determine the clinical effectiveness of whole-genome and transcriptome analysis (WGTA) to guide advanced cancer care.
- Conditions
- Metastatic Cancer, Advanced Cancer, Cancers That Cannot be Treated With Curative Intent
- Trial name
- NCT04141397
- Testing
- Initiation of POG-related WGTA, Usual care
- Volunteers
- 1,200 people
- Sponsor
- British Columbia Cancer Agency
Abnormal Karyotype
The Effectiveness of Blastocentesis Versus Trophectoderm Biopsy
For the purpose of this study, the investigators will perform the removal of trophectoderm (TE) the cells as required for the purpose of pre-implantation genetic screening, in order to perform the genetic analysis.
- Trial name
- NCT02915276
- Testing
- Blastocentisis, Trophectoderm biopsy
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
Asthma, Mastocytosis
Mast Cell Activation Test in Allergic Disease
Activation of mast cells in the immune system is known to cause allergic reactions sometimes with severe systemic symptoms. The investigators have recently developed a blood-based mast cell activation diagnostic test in which…
- Conditions
- Asthma, Mastocytosis, Mast Cell Activation Syndrome, Food Allergy
- Trial name
- NCT03406325
- Where
- Hong Kong
- Volunteers
- 19 people
- Sponsor
- Hong Kong Sanatorium & Hospital
Non-small Cell Lung Cancer (NSCLC)
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd) compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2) positive advanced or metastatic lung cancer without…
- Trial name
- TROPION-Lung17 (NCT07291037)
- Testing
- Datopotamab deruxtecan (Dato-DXd), Docetaxel
- Where
- 206 sites in United States, Australia and 19 more
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
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