Clinical trials: Geriatric Cancer Patients
Gastric Cancer, Gastric Adenocarcinoma
Frailty, Immunonutrition, Surgery Type, and Biologic Recovery in Elderly Gastric Cancer
This prospective observational cohort study will evaluate the effects of multidimensional frailty phenotypes, immunonutritional status, and surgical approach on biological recovery in patients aged 60 years and older undergoing…
- Trial name
- NCT07803159
- Testing
- Laparoscopic Gastrectomy, Open Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 328 people
- Sponsor
- Kocaeli City Hospital
Elderly, Prostate Cancer
Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients
This study seeks to identify if it is feasible to stop Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Therapy in elderly men with prostate cancer.
- Trial name
- NCT06824818
- Testing
- LHRH Agonist Therapy Discontinuation
- Where
- 2 sites in United States
- Volunteers
- 155 people
- Sponsor
- University of Chicago
Benign Prostate Hyperplasia, Bladder Tumor
Effective Dose of Dexmedetomidine for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia With or Without Fentanyl by Age Groups: Randomized Comparative Study
Recently many studies reported that intraoperative dexmedetomidine administration undergoing spinal anesthesia give a satisfactory sedation in elderly patients and cause less respiratory depressions compared other sedatives(e.g.
- Trial name
- NCT01665586
- Testing
- dexmedetomidine
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Non-Small Cell Lung Cancer
Random Trial for Elderly Patients With NSCLC
1. Recently a radomized trial of vinorelbine versus best supportive care in patients at 70 years of age or older demonstrated a definite improvement in overall survival rate and quality of life with chemotherapy. 2.
- Trial name
- NCT00265694
- Testing
- vinorelbine, gemcitabine and carboplatin
- Where
- South Korea
- Sponsor
- Inje University
Hodgkin Lymphoma
Adriamycin, Vinblastine, DTIC and Revlimid in Elderly Hodgkin Lymphoma Patients
The purpose of this study is to determine within the scope of the trial what the maximum tolerated dose (MTD) of lenalidomide in combination with AVD should be.
- Trial name
- AVD-Rev (NCT01056679)
- Testing
- Doxorubicine, DTIC, Lenalidomide
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
Hyperalgesia, Pain
Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy
The primary aim is to determine whether perioperative NMDA-receptor antagonism has differential effects on postoperative pain, hyperalgesia and morbidity in younger and older patients.
- Conditions
- Hyperalgesia, Pain, Prostate Cancer
- Trial name
- NCT00188383
- Testing
- Amantadine
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- University Health Network, Toronto
Neoplasm, Plasma Cell, Lymphoma
Impact of Chemotherapeutic Treatments in Patients Aged 75 Years and Over Treated for Lymphoid Hematological Malignancy
The aim of the study is to assess the prevalence of functional decline in elderly patients treated with chemotherapy or immunochemotherapy for lymphoid hematologic malignancies.
- Trial name
- LYMPHOLD (NCT05101759)
- Testing
- Comprehensive Geriatric Assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Extramedullary Plasmacytoma, Isolated Plasmacytoma of Bone
Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma
This phase II trial investigates whether patients greater than or equal to 65 years of age diagnosed with myeloma or another plasma cell malignancy will have better outcomes with transplant followed by maintenance therapy, as…
- Conditions
- Extramedullary Plasmacytoma, Isolated Plasmacytoma of Bone, Light Chain Deposition Disease, Primary Systemic Amyloidosis
- Trial name
- NCT01849783
- Testing
- dexamethasone, cisplatin, doxorubicin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Margarida Magalhaes-Silverman
Geriatric Assessment, Cancer
Effect of Comprehensive Geriatric Assessment on Short-time Mortality in Elderly Cancer Patients
Older cancer patients referred to Oncology outpatient Clinic at Aarhus University Hospital have for a period been offered Comprehensive geriatric Assessment (CGA) as part of a routine practice.
- Trial name
- NCT03814213
- Testing
- CGA, tailored care
- Where
- 2 sites in Denmark
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
Toripalimab Plus Rituximab Followed by R-CHOP for Elderly Patients With Untreated Diffused B Cell Lymphoma
1. Phase I portion of this study will evaluate the efficacy and saftey of toripalimab plus rituximab in treating untreated elderly diffuse large B cell lymphoma patients. 2.
- Conditions
- Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma Grade IIIb, Transformed Lymphoma
- Trial name
- NCT04058470
- Testing
- Toripalimab, Rituximab, R-CHOP Protocol
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Huiqiang Huang
Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8
Platinum-Based Chemotherapy and Durvalumab for the Treatment of Stage IIIB or IV Non-small Cell Lung Cancer
This phase II trial studies how well platinum-based chemotherapy works when given together with durvalumab in treating patients with stage IIIB or stage IV non-small cell lung cancer.
- Conditions
- Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8
- Trial name
- NCT04262869
- Testing
- Carboplatin, Durvalumab, Paclitaxel
- Sponsor
- Emory University
Ovarian Cancer, Breast Cancer
Comprehensive Outcomes for After Cancer Health
This study intends to explore feasibility, acceptability, and outcomes related to the use of a digital health coaching intervention for individuals who have completed primary therapy for cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Lung Cancer, Gastric Cancer
- Trial name
- COACH (NCT05349227)
- Testing
- Digital Health Coaching Program, Fitbit
- Where
- 7 sites in United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Pack Health
Glioblastoma, Malignant Glioma
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy
This phase II trial studies how well fluorodopa F 18-positron emission tomography/magnetic resonance imaging scan (18F-DOPA-PET/MRI) works in imaging elderly patients with newly diagnosed grade IV malignant glioma or glioblastoma…
- Trial name
- NCT03778294
- Testing
- Computed Tomography, Fluorodopa F 18, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Adult Acute Lymphocytic Leukemia
Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia
The aim of this study is to test feasibility and efficacy of a dose reduced chemotherapy in elderly patients with newly diagnosed acute lymphoblastic leukemia.
- Trial name
- NCT00199095
- Testing
- Adriamycin, Cyclophosphamide, Cytarabine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Goethe University
Breast Cancer, Cognitive/Functional Effects
Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly Diagnosed Breast Cancer or Colon Cancer
RATIONALE: Gathering health information from older patients undergoing chemotherapy may help doctors plan better treatment and improve the quality of life for these patients.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Colorectal Cancer, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00873600
- Testing
- chemotherapy, medical chart review, questionnaire administration
- Sponsor
- Case Comprehensive Cancer Center
Carcinoma, Non-Small-Cell Lung
An Dose Escalation Trial of Oral BIBF 1120 in Combination With Intravenous Vinorelbine in Elderly Patients With Advanced Non Small Lung Cell Cancer - Stage IV (VENUS-1)
To investigate the maximum tolerated dose of BIBF 1120, safety and pharmacokinetics in escalating doses administered with Vinorelbine i.v. in elderly patients with advanced Non-Small Lung Cancer (Stage IV).
- Trial name
- VENUS-1 (NCT01684111)
- Testing
- BIBF 1120, Vinorelbine
- Where
- 4 sites in Germany
- Volunteers
- 7 people
- Sponsor
- Aktion Bronchialkarzinom e.V.
Myelodysplastic Syndromes, Leukemia Myeloid Acute
A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated in the validation of the psychometric…
- Conditions
- Myelodysplastic Syndromes, Leukemia Myeloid Acute, Multiple Myeloma, Leukemia, Lymphocytic, Chronic, B-Cell
- Trial name
- NCT02842229
- Where
- 15 sites in Spain
- Volunteers
- 117 people
- Sponsor
- Celgene
Leukemia, Myeloid, Acute, MDS
Venetoclax Plus RIC Regimen Allo-HSCT for Elderly Patients With High-risk Myeloid Malignancies
This study is a single center, single arm, prospective, phase II clinical study to evaluate the efficacy and safety of Venatoclax combined with reduced intensity conditioning regimen allo-HSCT in the treatment of high-risk…
- Conditions
- Leukemia, Myeloid, Acute, MDS, Hematopoietic Stem Cell Transplantation, Myeloid Malignancy
- Trial name
- NCT05583175
- Testing
- Venetoclax plus RIC
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xianmin Song, MD
Metastatic Renal Cell Carcinoma
Sorafenib in Elderly Patients With Metastatic Renal Cell Carcinoma
Study Design This is a multicenter, open label, first line phase II study in elderly (≥ 65 years old) metastatic Renal Cell Carcinoma (mRCC) patients not suitable for any other currently approved treatment (bevacizumab+INF…
- Trial name
- SERCC (NCT01342627)
- Testing
- Sorafenib
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Advanced Soft-tissue Sarcoma, Metastatic Soft-tissue Sarcoma
Geriatric Assessmen of Elderly "Unsuited" Patients Receiving Trabectedin in First Line Treatment For Advanced Soft Tissue Sarcomas (STS)
The aim of the non-interventional study is to prospectively collect and analyze data on the geriatric assessment of patients undergoing systemic 1st line therapy with trabectedin with focus on patients who have been assessed by…
- Trial name
- E-TRAB (NCT03022448)
- Testing
- No Intervention
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 72 people
- Sponsor
- GWT-TUD GmbH
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