Clinical trials: Geriatric Cancer Patients
Carcinoma, Non-Small-Cell Lung
Efficacy and Safety Study of Afatinib to Treat Lung Cancer Patients
The purpose of this study is to examine the efficacy and safety of using afatinib (BIBW 2992) to treat non-small cell lung cancer patients considered unfit for chemotherapy and have either suspected or confirmed Epidermal Growth…
- Trial name
- TIMELY (NCT01415011)
- Testing
- Afatinib (BIBW 2992)
- Where
- 15 sites in United Kingdom
- Volunteers
- 39 people
- Sponsor
- University College, London
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia
Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy
This phase II trial studies how well eltrombopag olamine works in improving the recovery of platelet counts in older patients with Acute Myeloid Leukemia (AML) undergoing induction (the first treatment given for a disease)…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
- Trial name
- NCT02071901
- Testing
- eltrombopag olamine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Study to Assess Safety and PET Imaging Characteristics of a Novel Senescence-specific Radiotracer [18F]FPyGal (2-[Fluorine-18]Fluoro-3-pyridinyl-β-D-galactopyranoside)
It is of particular interest to find out whether it is possible to use the novel radiotracer [18F]FPyGal to be tested to detect areas after standard tumor therapy that contain resistant (therapy-resistant) tumor cells.
- Trial name
- SenPET (NCT04536454)
- Testing
- [18F]FPyGal
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital Tuebingen
Hepatobiliary Cancer, Pancreatic Cancer
Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer
The worldwide incidence of hepatobiliary and pancreatic (HPB) cancers is dramatically increasing especially for pancreatic cancer. Increasing age is associated with increased cancer risk.
- Trial name
- HPB70+ (NCT06999512)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 12 sites in France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Elderly, Frail
Effects of Multimodal Prehabilitation on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
Research indicates that prehabilitation is effective in optimizing physical status before surgery, although this method may be considered "aggressive" for frail elderly patients.
- Conditions
- Elderly, Frail, Gastric Cancer, Prehabilitation
- Trial name
- NCT06510088
- Testing
- 3-week multimodal prehabilitation program
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Breast Cancer
A Novel Approach Utilizing Organ Specific Age Proteomics
This study compares changes in P16INK4A expression and plasma proteomic signatures of specific organ age pre- and post-chemotherapy in women treated with adjuvant chemotherapy for early-stage breast cancer.
- Trial name
- NCT06789653
- Testing
- p16INK4a mRNA level assessment, organ-specific protein signatures assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diffuse Large B Cell Lymphoma, Follicular Lymphoma Grade 3B
Geriatric-guided Care Versus Conventional Care in Elderly Unfit/Frail Patients With Diffuse Large B-cell Lymphoma in First Line Treatment
The aim of this multicenter, non-randomized, cluster controlled trial study is to evaluate the impact of a geriatric-guided approach with a pro-active rehabilitative/nutritional plan for elderly unfit/frail DLBCL patients…
- Trial name
- NCT07476105
- Testing
- Geriatric-guided supportive care, Conventional supportive care
- Where
- 24 sites in Italy
- Volunteers
- 170 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Stage I Multiple Myeloma, Stage II Multiple Myeloma
Bortezomib, Dexamethasone, and Cyclophosphamide in Treating Older Patients With Multiple Myeloma
This phase II trial studies the side effects and how well lower doses of bortezomib, dexamethasone, and cyclophosphamide work in treating older patients with multiple myeloma.
- Conditions
- Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT02082405
- Testing
- bortezomib, cyclophosphamide, dexamethasone
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Cancer
Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma
NutriCa65-PDAC is a clinical study for patients aged 65 years or older with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
- Trial name
- NutriCa65-PDAC (NCT07821554)
- Testing
- Experimental: Personalised nutritional care delivered by a trained dietitian
- Where
- 5 sites in Denmark, Italy and 3 more
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
Cancer
A Geriatric Assessment Intervention for Older Cancer Patients Receiving Chemotherapy
The purpose of this study is to determine whether information regarding GA and GA-driven interventions improves outcomes in older cancer patients receiving first-line or second-line chemotherapy by comparing rates of chemotherapy…
- Trial name
- NCT01915056
- Testing
- GA-driven Intervention
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Rochester
Breast Cancer
Adjuvant Chemotherapy for Elderly Non Frail Patients With an Increased Risk for Relapse of a Primary Carcinoma of the Breast
Although approximately 50% of new diagnosis breast cancers are in patients above the age of 65, elderly people remain substantially under-represented in clinical trials, and therefore are under-treated.
- Trial name
- ICE-II (NCT01204437)
- Testing
- Epirubicin, Cyclophosphamide, Cyclophosphamide, Methotrexate, 5 FU, Capecitabine, Nab-Paclitaxel
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- GBG Forschungs GmbH
Non-small Cell Lung Cancer Metastatic, Non-small Cell Lung Cancer Stage IIIB
MILES-3: Cisplatin in Combination With Gemcitabine for Elderly Patients With Lung Cancer
The purpose of this study is to evaluate the addition of cisplatin to first-line chemotherapy with gemcitabine in elderly patients with non small cell lung cancer in terms of overall survival.
- Trial name
- MILES-3 (NCT01405586)
- Testing
- Gemcitabine, Cisplatin
- Where
- 49 sites in Italy
- Volunteers
- 299 people
- Sponsor
- National Cancer Institute, Naples
Esophageal Cancer
Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC
This study was conducted in elderly (≥70 years old) patients with locally advanced esophageal squamous cell carcinoma (ESCC). Aim to evaluate the efficacy and safety of Iparomlimab consolidation therapy following concurrent…
- Trial name
- NCT07038629
- Testing
- S1, Iparomlimab, Radiation
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems
A Comparative Study of CCI, EmSFI, and FTRST Scoring Systems
Frailty assessment tools and comorbidity indices play a crucial role, particularly in predicting outcomes for elderly patients undergoing emergency surgery.
- Conditions
- One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems, Gastrointestinal Neoplasms, Appendicitis Acute
- Trial name
- NCT06943924
- Testing
- Frailty assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Acute Myeloid Leukemia
A Pivotal Study of APG-2575 (Lisaftoclax) Combined With Azacitidine in the Treatment of Acute Myeloid Leukemia
A global, multicenter, randomized, double-blind, placebo-controlled, phase III pivotal registration study, to evaluate the efficacy of APG-2575 (Lisaftoclax) combined with azacitidine (AZA) versus placebo combined with…
- Trial name
- NCT06389292
- Testing
- APG-2575(Lisaftoclax ), Azacitidine Injection
- Where
- 6 sites in China, Russia
- Volunteers
- 486 people
- Sponsor
- Ascentage Pharma Group Inc.
Newly Diagnosed, Multiple Myeloma
Comparison of Melphalan-Prednisone (MP) to MP Plus Thalidomide in the Treatment of Newly Diagnosed Very Elderly Patients (> 75 Years) With Multiple Myeloma
In multiple myeloma, combination chemotherapy with melphalan plus prednisone has been usedsince the 1960s and is regarded as the standard of care in very elderly patients.
- Trial name
- IFM 01/01 (NCT00644306)
- Testing
- Thalidomide, melphalan, prednisone, melphalan, prednisone, thalidomide
- Where
- France
- Volunteers
- 232 people
- Sponsor
- Central Hospital, Nancy, France
Cervical Cancers
Effect of Nurse Navigation Program on Cervical Cancer Screening Behaviour of the Women Aged 30-65
This study was designed as a randomized controlled experimental study to examine the effect of the 'Nurse Navigation Program' on cervical cancer screening behaviors (Human Papilloma Virus (HPV) DNA screening test and/or pap smear…
- Trial name
- NCT06647992
- Testing
- Nurse Navigation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TURKAN OZDAS
Untreated Adult Acute Myeloid Leukemia, Effect of Drugs
Therapeutic Effect and Safety Study of Decitabine in Elderly Acute Myeloid Leukemia Patients
The purpose of this study is to confirm the safety and the therapeutic effect of Decitabine in the treatment of elderly Acute Myeloid Leukemia (AML) patients.
- Conditions
- Untreated Adult Acute Myeloid Leukemia, Effect of Drugs, Drug Safety
- Trial name
- NCT01633099
- Testing
- Decitabine
- Volunteers
- 46 people
- Sponsor
- Jianxiang Wang
Acute Myeloid Leukemia
Efficacy of 5-azacytidine Added to Standard Primary Therapy in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
The primary purpose of the study is to determine, whether the addition of 5-azacytidine to standard chemotherapy in elderly patients with newly diagnosed AML improves treatment results (event free survival).
- Trial name
- AML-AZA (NCT00915252)
- Testing
- azacitidine, standard chemotherapy (7+3 scheme): Daunorubicin, Cytarabine
- Where
- 27 sites in Germany
- Volunteers
- 214 people
- Sponsor
- University Hospital Muenster
Acute Myeloid Leukemia
Shortened Venetoclax Duration Based on Day 14 BM Blasts Versus Standard Therapy in Elderly or Frail Patients With AML Patients Treated With Azacitidine Plus Venetoclax
This study aims to compare the efficacy and safety of a shortened treatment course based on the bone marrow blast count on Day 14 versus standard treatment in patients with acute myeloid leukemia treated with venetoclax plus…
- Trial name
- NCT07407660
- Testing
- Venetoclax, Azacitidine (AZA)
- Volunteers
- 250 people
- Sponsor
- Peking University People's Hospital
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