Clinical trials: Geriatric Cancer Patients
Solid Carcinoma, Frailty
Geriatric Oncology Screening of Older Patients With Solid Cancers
Older patients with cancer constitute a heterogeneous group with varying comorbidity; therefore, geriatric assessment with initial screening is recommended. The Geriatric 8 (G8) has been established as a promising screening tool.
- Conditions
- Solid Carcinoma, Frailty, Age, Geriatrics
- Trial name
- PROGNOSIS-G8 (NCT04644874)
- Testing
- Geriatric 8, modified Geriatric 8, 30 second chair stand test
- Where
- Denmark
- Volunteers
- 1,401 people
- Sponsor
- Odense University Hospital
Leukemia, Lymphoblastic, Acute
"Geriatric Assessment Adapted" Therapy for Ph- ALL Elderly Patients
This study aims at considering clinical heterogeneity of patients based on a "geriatric assessment" without taking into account the real age of the subject.
- Trial name
- LAL1104 (NCT00475280)
- Testing
- Geriatric assessment adapted therapy, Stem cells autotransplantation
- Where
- 32 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Chronic Lymphocytic Leukemia
Ofatumumab as Front-Line Therapy in Treating Elderly Participants With Chronic Lymphocytic Leukemia
This phase II trial studies how well ofatumumab works as front-line therapy in treating elderly participants with chronic lymphocytic leukemia.
- Trial name
- NCT01444716
- Testing
- Ofatumumab
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Elderly, Cancer
Improving Quality of Life and Function for Older Cancer Patients Receiving Radiotherapy
This study is a first part of a larger project aiming at improving the following outcomes in older cancer patients receiving external beam radiation therapy (EBRT): quality of life, functioning and need for professional help…
- Conditions
- Elderly, Cancer, Radiotherapy Side Effect
- Trial name
- NCT03071640
- Where
- Norway
- Volunteers
- 302 people
- Sponsor
- Sykehuset Innlandet HF
Stomach Neoplasms, Aged
Prediction Model for Advanced Gastric Cancer in Elderly
This study aims to develop and validate a Nomogram (mCNS) model for predicting long-term survival in elderly patients following curative resection for advanced gastric cancer.
- Trial name
- NCT06467591
- Where
- China
- Volunteers
- 1,436 people
- Sponsor
- Chang-Ming Huang, Prof.
Esophageal Cancer
Phase II Study of Icotinib With Concurrent Radiotherapy in Elderly Patients With Esophageal Cancer
To investigate the efficacy and toxicity of EGFR tyrosine-kinase inhibitor (Icotinib) with concurrent radiotherapy in older patients with esophageal cancer.
- Trial name
- NCT02375581
- Testing
- Icotinib, Thoracic radiotherapy
- Where
- China
- Volunteers
- 130 people
- Sponsor
- First People's Hospital of Hangzhou
Esophageal Cancer
S-1 and Radiotherapy in Elderly Patients With Esophageal Cancer
Elderly patients with esophageal cancer will receive thoracic radiation therapy 54Gy over 30 fractions, and concurrent with s-1 on days 1-14 and 29-42 at the following dosages: 60, 70, and 80 mg/m(2)/day.
- Trial name
- NCT01175447
- Testing
- S-1
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhejiang Cancer Hospital
Head and Neck Cancer
A Study Comparing Geriatric Co-Management With Geriatric Guided Supportive Care in Older Patients Receiving Chemoradiation Therapy for Their Head and Neck Cancer
The researchers are doing this study to see whether geriatric co-management or geriatric guided supportive care are good approaches for managing side effects in older patients who have head and neck cancer and are receiving…
- Trial name
- NCT05239000
- Testing
- geriatric co-management, geriatric guided supportive care
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia
Acute Myeloid Leukaemia (AML) Patients Undergoing Induction Chemotherapy
Fatigue, reduced quality of life and declines in physical function are common in patients undergoing chemotherapy for acute myeloid leukaemia (AML).
- Trial name
- NCT01170598
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Toronto Rehabilitation Institute
Multiple Myeloma
Impacts on Health Outcomes and Resources Utilization of Hospital-at-home for Elderly Patients With Multiple Myeloma
The study aims to compare the overall survival adjusted to quality of life of 2 groups of patients with multiple myeloma, depending on the type of care: (1) day hospitalization exclusively or (2) day hospitalization combined with…
- Trial name
- PAMM-HAD1 (NCT03490084)
- Testing
- Association of day hospitalization with hospital-at-home, Day hospitalization exclusively
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bladder Cancer
Open Versus Laparoscopic Radical Cystectomy
To date, no trials have been designed to compare open Vs laparoscopic radical cystectomy in the elderly patients, both in terms of functional and clinical outcome measures.
- Trial name
- OvsL (NCT02345499)
- Testing
- Laparoscopic radical cystectomy with open urinary diversion, Open radical cystectomy with open urinary diversion
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Multiple Myeloma
Study of Teclistamab in Combination in Elderly Patients With Multiple Myeloma
The primary hypothesis of this study is that teclistamab SC in combination with daratumumab SC or lenalidomide will be safe and induce a high rate of VGPR or better in newly diagnosed multiple myeloma patients This is an…
- Trial name
- IFM2021-01 (NCT05572229)
- Testing
- Teclistamab, Daratumumab, Lenalidomide
- Where
- 22 sites in France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Cancer
Predisposing Factors Associated With Chemotherapy Toxicity in Elderly Cancer Patients
These days, there is higher proportion of elderly cancer patients. Most of them have comorbidities, borderline performance status and nutritional status.
- Trial name
- NCT02317757
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Mahidol University
Colorectal Cancer
Study of First-line Single-agent Panitumumab in Frail Elderly Patients With Advanced Wild Type K-RAS Colorectal Cancer
The purpose of the study is to evaluate the efficacy and safety of first-line single-agent panitumumab in frail elderly patients with advanced Wild Type K-RAS colorectal cancer
- Trial name
- FRAIL (NCT01126112)
- Testing
- Panitumumab
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Head and Neck Cancer
Magnesium Sulphate and Rocuronium in Patients Over 60
The purpose of this study is to evaluate the effects of MgSO4 administration on the pharmacodynamics of rocuronium in patients with 60 or more years of age.
- Trial name
- NCT01804205
- Testing
- Magnesium Sulfate
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pedro Rotava
Glioma, Glioblastoma
Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®
This is a phase 2, open-label clinical trial determining feasibility, safety, and tolerability of GammaTile® in elderly or frail subjects with newly diagnosed or recurrent malignant gliomas.
- Conditions
- Glioma, Glioblastoma, GBM, Glioma, Malignant
- Trial name
- ENDURANCE (NCT07821112)
- Testing
- GammaTile®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Prostate Cancer
A Study to Learn About Heart-Related Risks in Elderly Men With Advanced Prostate Cancer Treated With Enzalutamide or Darolutamide
This observational study aims to better understand the risk of serious heart-related problems in older men with advanced prostate cancer who are treated with certain commonly used medicines.
- Trial name
- NCT07672119
- Testing
- No intervention
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Bayer
Esophageal Cancer, Radiotherapy Side Effect
IMRT With Carboplatin Versus IMRT With Carboplatin and Fluorouracil for Eldly Esophageal Cancer Patients
An open, single-center, randomized controlled phase II clinical trial to compare the efficacy and safety of conformal intensity modulated radiation therapy (IMRT) combined with carboplatin and IMRT combined with carboplatin and…
- Trial name
- NCT03910634
- Testing
- Fluorouracil, Intensity modulated radiation therapy, carboplatin
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Sun Yat-sen University
Neoplasms (Cancer / Tumors), Geriatric Oncology
Optimising the Cancer Management of Older Patients by Early and Specific Geriatric Interventions.
The WARNING project proposes a new care organisation for older patients with cancer. The aim is to optimise management in daycare with early detection signs of geriatric syndromes and specific interventions.
- Trial name
- WARNING (NCT07704307)
- Testing
- WARNING Pack
- Volunteers
- 1,010 people
- Sponsor
- Poitiers University Hospital
Mantle Cell Lymphoma
Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
This is a phase II, single-arm, open-label, multicentre study of acalabrutinib and rituximab for elderly or frail patients with previously untreated mantle cell lymphoma.
- Trial name
- CARAMEL (NCT05004064)
- Testing
- Acalabrutinib, Rituximab
- Where
- 12 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London