Clinical trials: Geriatric Cancer Patients
Leukemia
AT9283 in Treating Young Patients With Relapsed or Refractory Acute Leukemia
RATIONALE: AT9283 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I/IIa clinical trial is studying the side effects and best dose of AT9283 in treating young…
- Trial name
- NCT01431664
- Testing
- multikinase inhibitor AT9283, laboratory biomarker analysis, pharmacological study
- Where
- 5 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Cancer Research UK
Diffuse Large B Cell Lymphoma
Prospective Clinical Study of ZPR Regimen in Elderly Treatment-naive Diffuse Large B-cell Lymphoma
This is a prospective, single-arm, single-center clinical study. This clinical study aims to explore the efficacy and safety of the ZPR（Zanubrutinib, Polatuzumab vedotin and Rituximab）regimen in elderly patients with…
- Trial name
- NCT05940064
- Testing
- Zanubrutinib, Polatuzumab Vedotin, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peng Liu
Leukemia, Myelomonocytic, Acute
Umbilical Cord Blood Transfusion in Consolidation Therapy of Elderly Patients With Acute Myeloid Leukemia
After complete remission, elderly AML patients cannot tolerate hematopoietic stem cell transplantation and standard-dose consolidation chemotherapy, and the 5-year survival rate is around 10%.
- Trial name
- NCT04687657
- Testing
- umbilical cord blood
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diffuse Large B-Cell Lymphoma
Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) in Elderly (More Than 60 Years) Patients With Diffuse Large B Cell Lymphoma After 4 Cycles of CHOP21-Rituximab (CHOP21-R) Therapy
Study phase: Phase II Investigational product, dosage, and route of administration: Ibritumomab tiuxetan ("Zevalin) is composed of a murine IgG1 monoclonal antibody (ibritumomab) covalently bound to the chelating agent tiuxetan.
- Trial name
- CHOP21+R-Z (NCT00850512)
- Testing
- CHOP21-R, Zevalin
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- University of Bologna
Colorectal Cancer
Study to Evaluate the Use of Capecitabine in Monotherapy and in Combination With Oxaliplatin in Elderly Patients as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer.
All patients with locally advanced colorectal cancer after radical surgical intervention who have not previously received systemic antitumor treatment will be randomized into two groups receiving fluoropyrimidines in mono-regimen…
- Trial name
- AHTCRR-1 (NCT06888843)
- Testing
- Capecitabine, Oxaliplatin
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Nizhny Novgorod Regional Clinical Oncology Center
Endometrial Cancer
A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for the Prevention of Endometrial Cancer in Patients Aged 40-50 With BMI Greater Than 35
Endometrial (uterine) cancer affects over 40,000 women each year in the United States. At this time there are no medications to prevent endometrial cancer. Women who are heavy are at increased risk of this cancer.
- Trial name
- NCT00161226
- Testing
- Levonorgestrel intrauterine system
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Cancer, Elderly Patients
Modification of the Quality of Life Based on Objective Geriatric Tests
The analysis of this study will achieve an improvement in the management of patients over 70 years with adaptation of chemotherapy regimens after analysis of the subject and its psychosocial environment.
- Trial name
- MEGERIA (NCT02873533)
- Testing
- geriatric care and longitudinal follow up
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Antoine Lacassagne
Pancreatic Cancer, Cholangiocarcinoma
Oral Protein Supplements for Nutritional and Quality of Life Improvement After Pancreatic Resection in Elderly Patients
This study investigates the effects of oral protein supplements on the nutritional status and quality of life in elderly patients following standard pancreatic resection.
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Intraductal Papillary Mucinous Neoplasm, Neuroendocrine Tumor
- Trial name
- NCT06570174
- Testing
- oral protein supplements
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Anaplastic Thyroid Cancer, Insular Thyroid Cancer
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer
This phase I trial is studying the side effects of gefitinib in treating patients with metastatic or unresectable head and neck cancer or non-small cell lung cancer.
- Conditions
- Anaplastic Thyroid Cancer, Insular Thyroid Cancer, Metastatic Parathyroid Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
- Trial name
- NCT00068497
- Testing
- gefitinib
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Acute Myeloid Leukemia (AML)
Exploratory Study of Venetoclax, Homoharringtonine, Azacitidine Plus G-CSF for Newly Diagnosed AML (VHAG)
This study is a single-arm, prospective, multi-center exploratory clinical trial. A total of 61 patients with newly diagnosed acute myeloid leukemia (AML) who are not suitable for intensive chemotherapy will be enrolled.
- Trial name
- VHAG (NCT07507825)
- Testing
- Intervention for Venetoclax, Intervention for Homoharringtonine, Intervention for Azacitidine
- Where
- China
- Volunteers
- 61 people
- Sponsor
- First People's Hospital of Hangzhou
Giant Cell Glioblastoma, Glioblastoma
Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma
- Trial name
- NCT01149850
- Testing
- bevacizumab, temozolomide, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Geriatric Oncology, Osteopathy in Other Diseases Classified Elsewhere
Osteopathic Manipulative Treatment in Oncology Patients' Management
The aim of present study was to study the osteopathic manipulative effects on pain relief and quality of life improvement on hospitalized oncology geriatric patients.
- Trial name
- NCT03142386
- Testing
- Osteopathic manipulative treatment, Physiotherapy
- Volunteers
- 23 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Sarcopenia, Lung Cancer
Lung Cancer Surgery in Sarcopenia Patients With Old Age
The presence of sarcopenia before lung resection surgery might be an important factor of short-term and long-term prognosis in lung cancer patients.
- Trial name
- LUCAS-PEN (NCT05346185)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Diffuse Large B Cell Lymphoma
Pola-R2 in Newly Diagnosed Non-fit Elderly DLBCL Patients
This is a prospective, single-arm, phase II study, and the purpose of this study is to evaluate the efficacy and safety of Pola-R2 regimen in newly diagnosed elderly diffuse large B cell lymphoma classified into un-fit or frail…
- Trial name
- NCT06176729
- Testing
- Polatuzumab Vedotin, Rituximab, Lenalidomide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yan Zhang, MD
Breast Neoplasms, Medication Adherence
A Novel E-Health Approach in Optimizing Treatment for Seniors (OPTIMUM Study)
Background: In women with hormone receptor positive (HR+) breast cancer, adjuvant endocrine therapy (AET) is associated with a significant survival advantage.
- Trial name
- NCT02876848
- Testing
- OPTIMUM e-health tool
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Lymphoma, Diffuse Large B-cell Lymphoma
Study of Lenalidomide Maintenance Versus Placebo in Responding Elderly Patients With DLBCL and Treated With R-CHOP
This study is designed as a phase III, randomized, double-blind, placebo-controlled trial to explore the effect of maintenance therapy with lenalidomide versus placebo on progression-free survival (PFS) in patients treated with…
- Trial name
- REMARC (NCT01122472)
- Testing
- Lenalidomide
- Where
- 157 sites in Australia, Austria and 7 more
- Volunteers
- 650 people
- Sponsor
- The Lymphoma Academic Research Organisation
Metastatic Breast Cancer, 70 Years Old Patients and Over
Evaluating Lapatinib + Capecitabine in Patients Aged 70 and Over With HER2 Metastatic Breast Cancer.
GERICO 09/0907 is a Phase II multicentric trial evaluating the toxicity and activity of the combination of lapatinib and capecitabine in locally advanced or metastatic breast cancer over expressing HER2 for patients aged ≥ 70 who…
- Conditions
- Metastatic Breast Cancer, 70 Years Old Patients and Over, After One Line of Chemotherapy With Trastuzumab
- Trial name
- GERICO09 (NCT01262469)
- Testing
- lapatinib + capecitabine
- Where
- 20 sites in France
- Volunteers
- 4 people
- Sponsor
- UNICANCER
Diffuse Large B Cell Lymphoma
Study Evaluating the Safety and Efficacy of iR2 in Untreated and Unfit Elderly Patients With DLBCL
This is a single-arm, open-label phase 2 study of iR2 in the treatment of unfit and elderly patients with untreated diffuse large B-cell lymphoma。
- Trial name
- NCT03949062
- Testing
- Ibrutinib, Lenalidomide, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Colorectal Cancer
Trial to Evaluate Laparoscopic Versus Open Surgery in Elderly Colorectal Cancer Patients
Elderly patients have poorer preoperative conditions than younger patients. Therefore, minimally invasive surgery should be an effective treatment method for elderly patients.
- Trial name
- NCT01862562
- Testing
- Open surgery, Laparoscopic surgery
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Shoichi Fujii, MD, PhD
Diffuse Large B-Cell Lymphoma (DLBCL)
A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP
Older patients with diffuse large B- cell lymphoma (DLBCL) do not have the same rates of disease control as younger patients and are at risk for toxicity.
- Trial name
- GOLD (NCT06828991)
- Testing
- Mosunetuzumab, ClonoSEQ
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Danielle Wallace
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