Clinical trials: Geriatric Cancer Patients
Rectal Cancer
Early-onset Rectal Cancer
The present study aimed to review the characteristics and outcome of early-onset rectal cancer in a subset of Egyptian patients aged 40 years or less.
- Trial name
- NCT04496765
- Testing
- Total mesorectal excision
- Where
- Egypt
- Volunteers
- 244 people
- Sponsor
- Mansoura University
CLL (Chronic Lymphocytic Leukemia)
A Trial to Evaluate the Efficacy and Safety of a Fitness-adapted Thera-py Approach With Either Continuous Zanubrutinib Monotherapy or Time-limited Zanubrutinib + Sonrotoclax in Older and/or Frail Patients With Treatment-naïve CLL
The CLL-Frail2 trial will be a prospective, open-label, multicentre phase-II-trial to evaluate the efficacy and safety of a fitness-adapted therapy approach with either con-tinuous zanubrutinib (BGB-3111) monotherapy or…
- Trial name
- NCT07899398
- Testing
- Zanubrutinib, Sonrotoclax
- Volunteers
- 80 people
- Sponsor
- German CLL Study Group
Elderly Patients, Metastatic Prostate Cancer
Predictive fActors for toleraNce to Taxane Based CHemotherapy In Older adultS Affected by mEtastatic Prostate Cancer
Aiming to explore predictive factors of fitness to taxane chemotherapy in elderly patients, the investigators collected data from a prospective mono-centric database of patients aged >/= 70 years old treated in our department…
- Trial name
- ANCHISES (NCT05471427)
- Testing
- Taxane chemotherapy
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Acute Myeloid Leukemia
Treatment of Older Adult Acute Myeloid Leukemia Patients Aged 55 to 65 Years
The purpose of this study is to determine whether the escalation dosage of Daunorubicin and cytarabine is effective and safety in the treatment of older adult Chinese acute myeloid leukemia（AML） patients aged 55 to 65 years.
- Trial name
- NCT02432872
- Testing
- Daunorubicin, Cytarabine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Jianxiang Wang
Pancreatic Cancer, Surgery
Quality of Life in Elderly Patients After Pancreatic Cancer Surgery
Pancreatic cancer mainly affects the elderly, with over 85% of patients diagnosed after the age of 60 and over half after the age of 70.
- Conditions
- Pancreatic Cancer, Surgery, Elderly
- Trial name
- ADL_DPC_PA (NCT06079229)
- Testing
- Phone call
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Hepatocellular Carcinoma
Radiofrequency Ablation Versus Liver Resection for Elderly Patients With Hepatocellular Carcinoma (HCC) Within the Milan Criteria
Hepatocellular carcinoma (HCC) is a common cancer, and it is the third commonest global cause of cancer-related death. With an increase in life-expectancy of the general population, the number of elderly with HCC is expected to…
- Trial name
- NCT01570075
- Testing
- HR, RFA
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University
Cancer
Automated Geriatric Co-Management Program in Older Patients With Solid Mass or Nodule Suspicious for Cancer
The purpose of this study is to find out if it is possible to use the automated geriatric co-management program to manage the participants care before, during and after surgery.
- Trial name
- NCT03885908
- Testing
- in-person geriatric co-management, automated geriatric co-management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Predictors of One-Year Mortality After Curative Surgery in Patients Aged 80 Years or Older With Non-Metastatic Colorectal Cancer
The aim of this study is to determine which preoperative factors are associated with one-year postoperative mortality in patients aged ≥80 years undergoing curative surgery and compare outcomes between patients with or without…
- Trial name
- NCT06704646
- Testing
- Curative intent surgery
- Volunteers
- 310 people
- Sponsor
- National Taiwan University Hospital
Carcinoma, Non-Small-Cell Lung
A Study Comparing Immunotherapy With Chemotherapy in the Treatment of Elderly Patients With Advanced NSCLC (MILES-5)
This is a randomized phase 2 trial aiming to assess the early efficacy of two experimental treatment sequences. Three arms are planned; (i) standard chemotherapy followed at progression by single agent immunotherapy with…
- Trial name
- MILES-5 (NCT03975114)
- Testing
- Chemotherapy, Durvalumab, Tremelimumab
- Where
- Italy
- Volunteers
- 460 people
- Sponsor
- National Cancer Institute, Naples
Colorectal Cancer
Advanced Geriatric Evaluation and Quality of Life in Colorectal Cancer Surgery
Colorectal cancer (CRC) disproportionately affects patients aged 70 years and older. Surgery is the main treatment modality for CRC, but is associated with increased risk of postoperative morbidity, disability and loss of health…
- Trial name
- AGE CRC (NCT04443816)
- Where
- 6 sites in Netherlands
- Volunteers
- 273 people
- Sponsor
- St. Antonius Hospital
Gastric Cancer, Frailty
Analysis of Influencing Factors of Preoperative Frailty in Elderly Patients With Gastric Cancer Based on the Health Ecology Theory
Frailty is common in patients with gastric cancer undergoing surgical treatment. Preoperative frailty can lead to many adverse outcomes in patients after surgery.
- Trial name
- NCT04929587
- Testing
- This is a observational research, there is no intervention
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Nanjing Medical University
Gastric Cancer
Evaluation of Efficacy and Safety of FOLFIRI Association Treatment in Patients 70 Years of Age and Older With Gastric Cancer
The number of patients over 70 years old with cancer is increasing in France. This population is heterogenous: physiological functions, presence of co-morbidities, and autonomy can vary a lot between subjects of the same age.
- Trial name
- CEPAFIRI (NCT00210184)
- Testing
- Irinotecan associated to fluorouracil and leucovorin
- Where
- 6 sites in France
- Volunteers
- 42 people
- Sponsor
- Institut Bergonié
Cancer, Radiotherapy
Improved Function and Quality of Life for Older Patients Receiving Radiotherapy, Part II
This cluster randomized controlled pilot study is designed to test the feasibility, and potential effect of a multicomponent, community-based intervention aiming to improve quality of life (QoL) and function for older patients…
- Conditions
- Cancer, Radiotherapy, Older Patients
- Trial name
- NCT03881137
- Testing
- Geriatric assessment with management
- Where
- 2 sites in Norway
- Volunteers
- 178 people
- Sponsor
- Sykehuset Innlandet HF
Acute Myeloid Leukemia
A Study Comparing Allogeneic Hematopoietic Cell Transplantation Versus Best Available Standard of Care Therapy in Elderly Patients With Acute Myeloid Leukemia
A subject of major interest for researchers, clinicians, patients, and payers, is the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of these older patients with AML.
- Trial name
- ALLO-BEST (NCT04822766)
- Testing
- Hematopoietic stem cell transplantation, Best chemotherapy treatment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer, Older Adults
Comprehensive Health Assessment for my Cancer Treatment Plan
Geriatric assessment (GA) predicts treatment toxicity and overall mortality in older adults with cancer. To improve treatment decision making in older adults with cancer, the American Society of Clinical Oncology (ASCO) and the…
- Trial name
- CHAMP-F (NCT05499975)
- Testing
- Self-reported online geriatric assessment (CHAMP)
- Where
- 3 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Acute Lymphoblastic Leukemia
Liposomal Anthracyclin in the Treatment of Elderly ALL
Phase II multicentric study comparing VAD regimen with continuous infusion over 96 hours of doxorubicin, vincristine and dexamethasone to a 90 minutes infusion of equivalent doses of Dox li-PEG, bolus infusion of vincristine and…
- Trial name
- NCT00600977
- Testing
- Doxorubicine, Doxorubicine pegylated
- Where
- France
- Volunteers
- 60 people
- Sponsor
- French Innovative Leukemia Organisation
Colorectal Neoplasms, Prostatic Neoplasms
Determinants of Quality Of Life in AGEd Cancer Patients
Patients face multiple stresses and challenges in the aftermath of cancer diagnosis. Despite needs perceived by elderly patients might differ from those of younger patients, there is a paucity of published data assessing the…
- Trial name
- DEQOLAGE (NCT02672657)
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-Small Cell Lung Cancer
A Study of Tarceva (Erlotinib) in Sequential Combination With Gemcitabine as First Line Therapy in Patients With Advanced Non-Small Cell Lung Cancer
This 2 arm study will compare the efficacy and safety of sequential treatment with Tarceva and gemcitabine, and of gemcitabine monotherapy, as first line treatment of elderly patients, or patients with ECOG performance status of…
- Trial name
- NCT00940875
- Testing
- erlotinib [Tarceva], gemcitabine
- Where
- 17 sites in Australia
- Volunteers
- 54 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer, Colorectal Cancer
Expectations and Priorities of Elderly Patients for a First Medical Treatment for Cancer
The main objective of study is to describe the priorities of elderly patients (70 years and over) undergoing a first medical treatment for cancer, at initiation of treatment and after 3 months of treatment.
- Conditions
- Breast Cancer, Colorectal Cancer, Kidney Cancer, Lung Cancer
- Trial name
- PRIORITY (NCT02821793)
- Testing
- Consultation, evaluation questionnaire, Geriatric consultation, evaluation questionnaire
- Where
- France
- Volunteers
- 346 people
- Sponsor
- Institut Bergonié
Surgery, Perioperative Care
Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer
The purpose of this study is to find out whether perioperative fluid restriction influence on postoperative immunological function. And discuss the probable mechanism that fluid restriction regime effect on clinical data.
- Conditions
- Surgery, Perioperative Care, Immunization, Abdominal Neoplasms
- Trial name
- NCT01399814
- Testing
- perioperative fluid management, perioperative fluid treatment
- Volunteers
- 179 people
- Sponsor
- Nanjing PLA General Hospital