Clinical trials: Geriatric Cancer Patients
Esophageal Cancer
Erlotinib and Radiation Therapy in Treating Older Patients With Stage I, Stage II, Stage III, or Stage IV Esophageal Cancer
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00524121
- Testing
- erlotinib hydrochloride, immunohistochemistry staining method, radiation therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Roswell Park Cancer Institute
CCND1 Positive, CD20-Positive Neoplastic Cells Present
Ibrutinib Plus Rituximab and Lenalidomide in Treating Elderly Participants With Newly Diagnosed Mantle Cell Lymphoma
This phase II trial studies how well ibrutinib plus rituximab and lenalidomide work in treating elderly participants with newly diagnosed mantle cell lymphoma.
- Conditions
- CCND1 Positive, CD20-Positive Neoplastic Cells Present, Mantle Cell Lymphoma
- Trial name
- NCT03232307
- Testing
- Dexamethasone, Ibrutinib, Lenalidomide
- Sponsor
- M.D. Anderson Cancer Center
Myeloma
Trial of Carfilzomib Plus Melphalan and Prednisone in Elderly Untreated Patients With Multiple Myeloma (CARMYSAP)
Phase I/II trial of Carfilzomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma. Nine: University Hospital of Nantes, University Hospital of Nancy, University Hospital of Lille, University…
- Trial name
- CARMYSAP (NCT01279694)
- Testing
- Carfilzomib, Melphalan, Prednisone
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Frailty, Cancer
Predictive Value of Geriatric Oncology Screening and Geriatric Assessment in Older Patients With Solid Cancers
A Randomized Clinical Trial examining the effects of Comprehensive Geriatric Assessment as an add on to oncologic treatment. Participants included are cancer patients found eligible for oncologic treatment, age 70 or more, and…
- Conditions
- Frailty, Cancer, Age
- Trial name
- PROGNOSIS-RCT (NCT04686851)
- Testing
- Comprehensive Geriatric Assessment and follow-up
- Where
- Denmark
- Volunteers
- 322 people
- Sponsor
- Odense University Hospital
Colorectal Cancer (CRC)
Transcutaneous Electrical Acustimulation on Postoperative Bowel Function Recovery in Elderly Patients
The goal of this clinical trial is to clarify the efficacy and safety of transcutaneous electrical acustimulation (TEA) in elderly patients with colorectal cancer, and to evaluate its clinical value in promoting postoperative…
- Trial name
- NCT07574502
- Testing
- TEA
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Sir Run Run Shaw Hospital
Esophageal Cancer, S-1
S-1 and Radiotherapy for Elderly Esophageal Cancer Patients
To investigate the efficacy and toxicity of S-1 with concurrent radiotherapy in older patients with esophageal cancer.
- Conditions
- Esophageal Cancer, S-1, Radiotherapy
- Trial name
- NCT02716688
- Testing
- S-1, radiotherapy
- Where
- China
- Sponsor
- Zhejiang Provincial People's Hospital
Colorectal Cancer
An Observational Study of Avastin in First Line in Elderly Patients With Metastatic Colorectal Cancer (CASSIOPEE)
This multicenter, prospective, observational study will evaluate the efficacy and safety of Avastin (bevacizumab) in first-line therapy in elderly patients with metastatic colorectal cancer.
- Trial name
- NCT01555762
- Where
- 166 sites in France
- Volunteers
- 402 people
- Sponsor
- Hoffmann-La Roche
Hematologic Malignancy
Patient-Centered Care for the Older Adult With Hematologic Malignancy
This research study is evaluating if co-management by a geriatrician embedded in the oncology clinic can improve outcomes for frail older adults with blood cancers.
- Trial name
- NCT02359838
- Testing
- Baseline Geriatric Screening/Assessment, Geriatrician Co-Management
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Dana-Farber Cancer Institute
Diffuse Large B Cell Lymphoma
Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma
To explore the clinical features and efficacy evaluation of large b-cell lymphoma in old age.
- Trial name
- NCT03513601
- Testing
- (R)-CHOP regimen, (R)-CVP regimen
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Mingzhi Zhang
Surgery, 75 Years Old and More
Place of Comprehensive Geriatric Assessment in Patients ≥ 75 Years Care, With Breast Cancer, After Screening With FOG (Oncology Geriatric Filter)
The risk of diagnosis of cancer increases with age, especially breast cancer in elderly women. Elderly population is heterogeneous, regarding physiological reserves, comorbidities, disability and geriatric conditions.
- Conditions
- Surgery, 75 Years Old and More, Female Breast Cancer
- Trial name
- NCT03059875
- Testing
- Medical consultation for a Standardized Geriatric Evaluation
- Where
- 6 sites in France
- Volunteers
- 79 people
- Sponsor
- Poitiers University Hospital
Acute Myeloid Leukemia
Venetoclax + Cytarabine Versus Idarubicin + Cytarabine : Efficacity Assessment as Post-remission Therapy to Elderly Patients With Acute Myeloid Leukemia in First Remission
For the FILO group, the standard of care for induction chemotherapy of elderly fit patients with AML is represented by the combination of Cytarabine, Idarubicin and Lomustine.
- Trial name
- LAMSA2020 (NCT04968015)
- Testing
- Cytarabine-Venetoclax Association, Cytarabine-Idarubicin Association
- Where
- 26 sites in France
- Volunteers
- 134 people
- Sponsor
- French Innovative Leukemia Organisation
Stage III Non-small-cell Lung Cancer
Chemoradiation Followed by Durvalumab in Poor Risk and/or Elderly Patients With Stage III NSCLC
Elderly (age 70 years or older) or >18 years old AND poor risk (ECOG 2) newly diagnosed stage IIIA-C (AJCC 8th edition) inoperable non-small cell lung cancer (NSCLC) patients are eligible to participate in this phase II open…
- Trial name
- ESR1814205 (NCT04441138)
- Testing
- Durvalumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center
Nasopharyngeal Neoplasms, Elderly
IMRT Combined With Lobaplatin-based CCRT in Nasopharyngeal Carcinoma
This prospective, multicenter, single-arm, open-label phase II clinical study aimed to investigate the efficacy and safety of intensity-modulated radiotherapy combined with lobaplatin-based concurrent chemotherapy in the…
- Conditions
- Nasopharyngeal Neoplasms, Elderly, Chemotherapy
- Trial name
- NCT06688175
- Testing
- IMRT combined with lobaplatin-based concurrent chemotherapy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Colon Cancer, Rectal Cancer
CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC
This is a prospective, multicentre, cohort study. For cohort 1, experimental cohort, older or Frail patients with inoperable localized colorectal cancer will receive Ultrafractionated Radiotherapy (RT) and Comprehensive Geriatric…
- Trial name
- NCT06652412
- Testing
- Ultrafractionated RT and CGA Guided systemic treatment., data prospectively collected, Ultrafractionated Radiotherapy
- Volunteers
- 124 people
- Sponsor
- Fudan University
Lymphoma
Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or High-Grade Non-Hodgkin's Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different ways may kill more tumor cells.
- Trial name
- NCT00003113
- Testing
- filgrastim, cyclophosphamide, etoposide
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Case Comprehensive Cancer Center
Polycystic Ovary Syndrome
Effect of Metformin and Probiotics in Reproductive-aged Patients With Polycystic Ovary Syndrome
The purpose of this clinical trial is to evaluate the safety and effectiveness on the clinical and biological parameters of reproductive-aged PCOS women after a 12-week metformin and/or probiotics administration.
- Trial name
- NCT03336840
- Testing
- Metformin tablets, ProMetS probiotics powder, 1. Metformin tablets; 2. ProMetS probiotics powder
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Bladder Cancer
Comprehensive Geriatric Assessment (Tests) for Bladder Cancer Participants Undergoing Radical Cystectomy
This study focuses on providing an educational program for people/participants with bladder cancer who plan to have a cystectomy (surgery) as part of their standard care.
- Trial name
- NCT06427824
- Testing
- Educational Video Modules on Risk Prevention Before and After Cystectomy (Surgery), Geriatric Service/ Discharge Planning, Questionnaires
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Chicago
Mantle Cell Lymphoma
Ibrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged ≤65 Years
The purpose of the study is to better and systematically collect clinical data on the treatment of ibrutinib combined with R-CHOP/DHAP regimen for more scientific and accurate evaluation, our center has carried out the…
- Trial name
- NCT05429918
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Multiple Myeloma, Cancer
Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma
This research study is investigating the safety and effectiveness of using combination of isatuximab, lenalidomide and dexamethasone for the treatment of newly diagnosed multiple myeloma (MM).
- Trial name
- NCT05145400
- Testing
- Isatuximab, Lenalidomide, Dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Advanced Biliary Tract Cancer
Safety and Efficacy of Gemcitabine, Toripalimab and Dose- Modified Lenvatinib in Elderly Patients With Advanced Biliary Tract Cancer Intolerant to Conventional Chemotherapy
The goal of this clinical trial is to learn if the regimen of gemcitabine, toripalimab and dose-modified lenvatinib works to treat advanced biliary tract cancer in elderly patients with intolerance to conventional chemotherapy.
- Trial name
- ZSAB-GENTLE (NCT07897565)
- Testing
- gemcitabine, toripalimab, and lenvatinib capsules
- Volunteers
- 39 people
- Sponsor
- Shanghai Zhongshan Hospital
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