Clinical trials: Geriatric Cancer Patients
Exhaustion, Geriatric Disorder
Nursing Follow up in Geriatric Oncology : Tracking Time of Caregiver Exhaustion Risk
In geriatric oncology, caregivers are submitted to a risk of exhaustion. To investigate the clinical risk factor of exhaustion, the researchers propose to conduct a prospective observational study during 6 months phone follow up…
- Trial name
- TANGO (NCT02551965)
- Testing
- Phone nursing follow-up
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Acute Myeloid Leukemia
Venetoclax and Decitabine Assessment in Patients (≥60 - <75 Years) with Newly Diagnosed AML Eligible for Allo-SCT
This trial is a no profit, prospective, phase II, multicentre, non-randomised, uncontrolled, single group assignment, open label study to evaluate the safety and efficacy of the "chemo-free" combination Venetoclax plus Decitabine…
- Trial name
- NCT04476199
- Testing
- Venetoclax and Decitabine
- Where
- 25 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Stomach Neoplasms, Frail Elderly
Multimodal Prehabilitation To Improve The Clinical Outcomes Of Frail Elderly Patients With Gastric Cancer
The GISSG+2201 study was launched by Shandong Gastrointestinal Surgery Study Group (GISSG). The intention is to establish a multimodal prehabilitation protocol in frail elderly patients who undergo gastric cancer radical surgery…
- Trial name
- NCT05352802
- Testing
- Multimodal prehabilitation program, ERAS protocol
- Where
- China
- Volunteers
- 368 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Acute Myeloid Leukaemia; Myelodysplastic Syndromes;Chronic Myelomonocytic Leukemia
Azacytidine + HAG Regimen vs. Azacytidine for Elderly Patients With Newly Diagnosed Myeloid Malignancy
The primary objective is to explore the efficacy and safety of azacytidine and HAG regimen versus azacytidine for elderly patients with Newly Diagnosed MDS/AML/CMML in China.
- Trial name
- NCT03873311
- Testing
- Azacytidine, HAG Regimen, Azacytidine
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Shenzhen Second People's Hospital
Sarcoma, Soft Tissue
Trofosfamide Versus Adriamycin in Elderly Patients With Soft Tissue Sarcoma (STS)
The goal of this trial is to determine whether oral continuous (metronomic) therapy with trofosfamide results in a similar rate of progression-free time after 6 months as intravenous treatment with adriamycin.
- Trial name
- NCT00204568
- Testing
- Adriamycin, Trofosfamide
- Where
- Germany
- Volunteers
- 117 people
- Sponsor
- University Hospital Schleswig-Holstein
Acute Myeloid Leukemia
Treatment of Acute Myeloid Leukemia (AML) in Adults 50 to 70 Years, Study of Two Anthracyclines and the Interest of Maintenance Treatment With Interleukin 2
Randomized comparison of standard induction treatment with daunorubicin for 3 days and Idarubicin for 3 or 4 days in adult AML patients between 50 and 70 years. Study of maintenance treatment with IL2
- Trial name
- ALFA 9801 (NCT00931138)
- Testing
- chemotherapy (Aracytine + Daunorubicin)
- Where
- 16 sites in France
- Volunteers
- 420 people
- Sponsor
- Acute Leukemia French Association
Mortality, Surgery
Mortality Score in Elderly Patients With Colon Cancer
CR-POSSUM is one of the most used surgical scores to predict mortality after colorectal surgery. Its main drawback is the requirement of intraoperative variables, whose collection is time-consuming and prevents from obtaining a…
- Conditions
- Mortality, Surgery, Colon Cancer
- Trial name
- MECC (NCT04538404)
- Testing
- Colon Surgery
- Where
- 2 sites in Italy
- Volunteers
- 385 people
- Sponsor
- University of Bologna
Pathology
Incidental Cancer in Gallbladder Surgical Specimens Focus on Elderly Patients
Causes such as long-term stones and polyp are thought to play a role in the etiology of gallbladder cancer. The routine histopathological examination provides the detection of incidental gallbladder cancers.
- Trial name
- NCT04352478
- Testing
- Histopathological result
- Where
- Turkey (Türkiye)
- Volunteers
- 2,389 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital
Newly Diagnosed Multiple Myeloma
Study of SubQ Dara With Dose-Attenuated Bortezomib, Lenalidomide, Dexamethasone in Elderly NDMM
This is a single center, open-label, phase 2 study in elderly (age ≥ 70) subjects with newly diagnosed multiple myeloma who are transplant ineligible.
- Trial name
- NCT04052880
- Testing
- Daratumumab, Bortezomib, Lenalidomide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Larysa Sanchez
Cancer, Undernutrition
Nutritional Intervention in Geriatric Oncology
Older patients with cancer are poorly treated or not treated at all. A previous study in the south west of France (364 patients) showed that patients receiving chemotherapy had short survival times which strongly depended on…
- Conditions
- Cancer, Undernutrition, Aging
- Trial name
- INOGAD (NCT00459589)
- Testing
- nutritional intervention with dietician plus usual nutritional care, usual nutritional care
- Where
- 2 sites in France
- Volunteers
- 341 people
- Sponsor
- University Hospital, Bordeaux
Myelogenous Leukemia, Acute, Myelodysplastic Syndromes
MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With Relapsed/Refractory Disease
In this study, MGCD0103, a new anticancer drug under investigation, is given three times per week to elderly patients with previously untreated acute myelogenous leukemia/high risk myelodysplastic syndrome or adults with…
- Trial name
- NCT00374296
- Testing
- MGCD0103
- Where
- 13 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- Mirati Therapeutics Inc.
Generalized Myasthenia Gravis
A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.
The study is a randomized, double-blind, placebo-controlled, multicenter, Phase III study, to evaluate efficacy, safety and tolerability of iptacopan in patients with AChR+ gMG who are on stable SOC treatment.
- Trial name
- NCT06517758
- Testing
- Iptacopan
- Where
- 116 sites in United States, Argentina and 16 more
- Volunteers
- 146 people
- Sponsor
- Novartis Pharmaceuticals
Lung Neoplasms
The Impacts of Pulmonary Rehabilitation Therapy on Patients After Thoracic Surgery
The advantages of thoracoscopic surgery include smaller wounds, fewer postoperative complications, and shortened hospital stay. However,complications such as pain, pulmonary function insufficiency, pneumonia,postoperative…
- Trial name
- VATSMIPMEP (NCT02757092)
- Testing
- Home-based Pulmonary Rehabilitation
- Where
- 2 sites in Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Cancer
Elevate! : An Elderly Breast Cancer Cohort Study
This study is focused on understanding how the investigators can improve upon breast cancer and health outcomes for older participants with breast cancer.
- Trial name
- NCT03818087
- Testing
- Observational cohort
- Where
- 4 sites in United States
- Volunteers
- 253 people
- Sponsor
- Dana-Farber Cancer Institute
Hematological Cancers, Frailty
Improving Quality of Life in Frail, Older Patients with Hematological Cancer Through Geriatric Assessment and Treatment - a Pilot Study
Purpose of the Study This study aims to assess the feasibility of conducting outpatient geriatric health assessment (comprehensive geriatric assessment - CGA) alongside initiation of hematological cancer treatment in frail older…
- Conditions
- Hematological Cancers, Frailty, ELDERLY PEOPLE
- Trial name
- IMPROVE pilot (NCT06689332)
- Testing
- Comprehensive Geriatric Assessment
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- Odense University Hospital
Breast Cancer
GEriatric Determinants of Curative RAdiotherapy Scheme Choice for Breast Cancer ELderly Patient Treatment Compliance and Tolerance
This study proposes an onco geriatric evaluation (Activities of Daily Living, Instrumental Activities Of Daily Living, Mini Mental State Examination, mini Geriatric Depression Scale, Mini Nutritional Assessment, Cumulative…
- Trial name
- GERABEL (NCT02994914)
- Testing
- Onco Geriatric Evaluation
- Where
- 3 sites in France
- Volunteers
- 241 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Non-small Cell Lung Cancer (NSCLC)
Chemotherapy Plus Bevacizumab in Elderly Non-small Cell Lung Cancer Patients
A phase II Study of an adapted chemotherapy regimen plus bevacizumab in elderly non-small cell lung cancer patients selected by geriatric assessment
- Trial name
- NCT01980472
- Testing
- bevacizumab, carboplatin and paclitaxel
- Where
- 10 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Grupo de Investigación y Divulgación Oncológica
Non-Small Cell Lung Cancer
Efficacy and Safety of Sintilimab Combined with Platinum-containing Double-agent Chemotherapy in First-line Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer in Elderly Patients
To investigate the efficacy and safety of sindilizumab combined with platinum-containing dual chemotherapy in first-line treatment of elderly patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Trial name
- NCT06883136
- Testing
- Sintilimab+Cis-platinum/Carboplatin with Pemetrexed or Gemcitabine
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- Qianfoshan Hospital
Acute Myeloid Leukemia (AML) With Multilineage Dysplasia Following Myelodysplastic Syndrome, in Adults, AML (Adult) With 11q23 (MLL) Abnormalities
Decitabine and Midostaurin in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
This phase 2 study evaluates the sequential combination of decitabine then midostaurin for the treatment of newly-diagnosed acute myeloid leukemia (AML) in older patients.
- Conditions
- Acute Myeloid Leukemia (AML) With Multilineage Dysplasia Following Myelodysplastic Syndrome, in Adults, AML (Adult) With 11q23 (MLL) Abnormalities, AML (Adult) With Del (5q), AML (Adult) With Inv (16) (p13; q22)
- Trial name
- NCT01846624
- Testing
- Decitabine, Midostaurin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- David Iberri
Metastatic Cancer
Stereotactic Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Stereotactic radiation therapy may be able to deliver x-rays directly to the tumor and cause less damage to normal tissue.
- Trial name
- NCT00006259
- Testing
- stereotactic radiosurgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Comprehensive Cancer Center
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