Clinical trials: Geriatric Cancer Patients
Acute Myeloid Leukemia
Deferasirox, Cholecalciferol, and Azacitidine in the Treatment of Newly Diagnosed AML Patients Over 65
The purpose of this study is to find out if by giving a combination of 3 drugs the leukemia will go into complete remission (meaning the leukemia is completely gone), and to find out how long it stays away.
- Trial name
- EXJADE (NCT02341495)
- Testing
- Deferasirox, Cholecalciferol, Azacitidine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Elizabeth Henry
Diffuse Large B Cell Lymphoma
Ibrutinib, Bortezomib and Rituximab-CHOP for the Treatment of Elderly Patients With CD20+ DLBCL, IPI ≥ 2
The ImbruVeRCHOP-Trials is an Investigator-initiated, single-arm, multi-center, prospective, open phase I/II trial to evaluate the efficacy and feasibility of Ibrutinib and Bortezomib in the therapy of higher-risk DLBCL patients…
- Trial name
- ImbruVeRCHOP (NCT03129828)
- Testing
- Ibrutinib and Bortezomib + R-CHOP
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Prof. Dr. Clemens Schmitt
Thoracic Neoplasms, Lung Neoplasms
Thoracic OncoGeriatric Assessment (TOGA) Trials
Our goal is to develop a reliable, physician and patient-friendly, pre-operative Thoracic Onco-Geriatric Assessment (TOGA) to predict surgical risk in geriatric oncology patients with thoracic neoplasms of the lung, esophagus…
- Conditions
- Thoracic Neoplasms, Lung Neoplasms, Esophagus Neoplasms, Pleural Neoplasms
- Trial name
- TOGA (NCT00591981)
- Testing
- TOGA Tools
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Acute Myeloid Leukemia
Program of Evaluation and Geriatric Intervention on the Functional Status, Quality of the Life, and Survival
Acute myeloid leukaemia (AML) is a disease of the elderly, with a median age at diagnosis of 65. A poor outcome in this population has been well established, with very short overall survival (OS) and disease free survival…
- Trial name
- MLSP (NCT01188330)
- Testing
- WITH Comprehensive Geriatric assessment, Conventional
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut Paoli-Calmettes
Recurrent Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Frailty Index and Geriatric Assessment in Predicting Toxicity to Front-Line Chemotherapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer
This phase II trial is studying how well a frailty index and geriatric assessment works in predicting toxicity to front-line chemotherapy in treating patients with stage IV non-small cell lung cancer.
- Trial name
- NCT01026467
- Testing
- cisplatin, carboplatin, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Wake Forest University Health Sciences
Acute Myeloid Leukemia, in Relapsed or Refractory, Acute Myeloid Leukemia, Elderly, Unfit
Combined Inhibition of PD-1 and DNA Hypomethylating Agent +/- Chemotherapy in High-risk AML or Elderly Patients With AML Who Are Unfit for Intensive Chemotherapy
This phase II trial studies how well tislelizumab combined with DNA hypomethylation agent +/- CAG regimen (cytarabine, idarubicin / Aclarithromycin, rhG-CSF/ PEG-rhG-CSF) work in treating patients with high-risk acute myeloid…
- Conditions
- Acute Myeloid Leukemia, in Relapsed or Refractory, Acute Myeloid Leukemia, Elderly, Unfit, Acute Myeloid Leukemia With Positive Minimal Residual Disease
- Trial name
- NCT04541277
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Chinese PLA General Hospital
Cancer, Rectal
Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer
This study will help determine if a short course of radiation therapy is effective to treat rectal cancer in older patients. A shorter course of radiation treatment may be better tolerated than a longer course or surgery for the…
- Trial name
- NCT04139967
- Testing
- Short course radiation therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Rochester
Non-Small Cell Lung Cancer
Phase I/II Trial of Bevacizumab, Pemetrexed and Erlotinib in Elderly Patients With Non-Small Cell Lung Cancer
This is a Phase I/II trial of elderly patients (> 70 years of age). Patients in this age group with previously un-treated Advanced Stage Non-Squamous Non-Small Cell Lung Cancer (NSCLC) with Stage IIIB (with malignant pleural…
- Trial name
- NCT00351039
- Testing
- Bevacizumab, Erlotinib, Pemetrexed
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastric Cancer
Handgrip Strength (HGS) With HGS Asymmetry Are Associated With All-cause Mortality and Hospital Readmissions
Adding the handgrip strength (HGS) asymmetry to the existing measurements of low HGS may improve the assessment of muscle function.
- Trial name
- NCT05397444
- Testing
- No intervention
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Nanjing Medical University
Non-Small-Cell Lung Cancer, Neoadjuvant Therapy
Oral Paclitaxel as Neoadjuvant Therapy in Elderly NSCLC: A Phase II Trial
This study is a multicenter, single-arm Phase II clinical trial, aiming to explore the safety and preliminary efficacy of oral paclitaxel solution combined with immune checkpoint inhibitors as a neoadjuvant regimen in elderly…
- Conditions
- Non-Small-Cell Lung Cancer, Neoadjuvant Therapy, Paclitaxel
- Trial name
- NCT07599163
- Testing
- Paclitaxel Oral Solution
- Volunteers
- 75 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Acute Myeloid Leukemia
Efficacy Study of Anti-KIR Monoclonal Antibody as Maintenance Treatment in Acute Myeloid Leukemia (EFFIKIR)
Double-Blind Placebo-Controlled Randomized Phase 2 Study evaluating the efficacy of lirilumab (IPH2102/BMS-986015) as Maintenance Treatment administered in elderly patients with Acute Myeloid Leukemia (AML) in first complete…
- Trial name
- EFFIKIR (NCT01687387)
- Testing
- IPH2102 at 0.1 mg/kg, IPH2102 at 1 mg/kg
- Where
- 43 sites in France
- Volunteers
- 152 people
- Sponsor
- Innate Pharma
Adenocarcinoma Pancreas
Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients
The GrantPax study is a multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/- nab-paclitaxel in elderly pancreatic cancer patients.
- Trial name
- GrantPax (NCT02812992)
- Testing
- Nab-paclitaxel, Gemcitabine, Best Supportive Care
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- AIO-Studien-gGmbH
Non-Hodgkin's Lymphoma
A Study of MabThera (Rituximab) in Elderly Patients With Untreated Follicular Non-Hodgkin's Lymphoma (NHL)
This study will evaluate the efficacy and safety of brief induction therapy with a chemotherapeutic regimen containing MabThera, followed by either maintenance therapy with MabThera or no further therapy.
- Trial name
- NCT01144364
- Testing
- rituximab [Mabthera/Rituxan]
- Where
- 45 sites in Italy
- Volunteers
- 234 people
- Sponsor
- Hoffmann-La Roche
Oncology
Geriatric Assessment Reporting in Real Time (GARRT) in Non-electively Hospitalized Older Cancer Patients
This study prospectively evaluates the impact of geriatric assessment reporting in real-time (GARRT) on key hospital based outcomes in a cohort of non-electively hospitalized older (> 70 years) adults with cancer.
- Trial name
- NCT03951090
- Testing
- Results of the brief geriatric assessment, No results of brief geriatric assessments
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diffuse Large Cell Lymphoma
ACVBP Plus Rituximab in Patients Aged From 18 to 59 Years With High-risk Diffuse Large B-cell Lymphoma
This study is a multicentric trial evaluating the efficacy of R-ACVBP in patients aged 18 to 59 years with high risk diffuse large B-cell lymphoma
- Trial name
- NCT00144807
- Testing
- rituximab, doxorubicin, cyclophosphamide
- Where
- 13 sites in Belgium, France and 1 more
- Volunteers
- 128 people
- Sponsor
- Lymphoma Study Association
Diffuse Large B-Cell Lymphoma, Elderly Patients
Prephase Treatment With Prednisone +/- Vitamin D Supplementation Followed by Immunochemotherapy
This is an open-label, multicenter, randomized phase III trial. The study plans to randomize patients with a 1 to 1 ratio to Arm A (Standard arm) or Arm B (Experimental arm).
- Trial name
- FIL_PREVID (NCT04442412)
- Testing
- Vitamin D3 (Cholecalciferol), RCHOP o R-miniCHOP at standard doses
- Where
- 49 sites in Italy
- Volunteers
- 430 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Solid Cancer, Lymphopenia
PRaG-1 Plus PRaG Therapy in in Elderly Patients With Advanced Solid Tumors: A Prospective Clinical Trial (PRaG 10.0)
The goal of this clinical trial is to learn if a combination treatment using PRaG-1 Cordycepin Tablets with radiation therapy, immune-boosting injections, and immunotherapy drugs can help patients with advanced solid tumors.
- Conditions
- Solid Cancer, Lymphopenia, Radiotherapy, Immune Checkpoint Inhibitor
- Trial name
- NCT07267234
- Testing
- PD -1/PD-L1 monoclonal antibody
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Follicular Lymphoma
BRIEF Bendamustine and Rituximab In Elderly Follicular
The objective of this study is to evaluate the complete response rate after a short induction treatment with rituximab (375mg/m2)and bendamustine (90mg/m2)in In Elderly (≥ 60 years old) patients with untreated Follicular…
- Trial name
- BRIEF (NCT01313611)
- Testing
- Rituximab + bendamustine
- Where
- 117 sites in Belgium, France
- Volunteers
- 62 people
- Sponsor
- The Lymphoma Academic Research Organisation
Cancer of Head and Neck
Study Comparing Pembrolizumab With Methotrexate in Elderly, Frail or Cisplatin-ineligible Patients With Head and Neck Cancers
The study is designed as an open-label, randomized, prospective, multicenter, phase II study comparing pembrolizumab with methotrexate in elderly, frail or cisplatin-ineligible patients with squamous carcinoma of the head and…
- Trial name
- ELDORANDO (NCT03193931)
- Testing
- Pembrolizumab Injection, Methotrexate Injectable Solution
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- AIO-Studien-gGmbH
Rectal Cancer
External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer
ACO/ARO/AIO-22 - External beam radiotherapy combined with endorectal high-dose-ratebrachytherapy in elderly and frail patients with rectal cancer. A prospective multicentre trial of the German Rectal Cancer Study Group.
- Trial name
- ACO/ARO/AIO-22 (NCT06729645)
- Testing
- radiotherapy
- Where
- 4 sites in Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital of Cologne
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