Clinical trials: Geriatric Cancer Patients
Hodgkin's Disease
Study of Prednisone, Vinblastine, Doxorubicin, and Gemcitabine in Elderly Patients With Advanced Stages Hodgkin's Lymphoma
The objectives of this study are to assess the feasibility and efficacy of a combination chemotherapy (PVAG) in elderly patients with advanced stages Hodgkin's lymphoma.
- Trial name
- NCT00147875
- Testing
- Prednisone, Vinblastine, Doxorubicin (Adriamycin)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Newly Diagnosed Glioblastoma in Patients ≥70 Years
Effect of Timing of Tumor-Treating Fields Plus Short-Course Radiation
The purpose of the study is to assess timing of TTFields use as well as safety, feasibility and preliminary efficacy of treatment with TTFields in elderly patients with newly diagnosed GBM simultaneous to RT/ CRT.
- Trial name
- GERAS (NCT04218019)
- Testing
- TTFields
- Where
- Germany
- Sponsor
- Juergen Debus
Hodgkin Lymphoma
Immunological Senescence Phenotype as a Resistance Profile to Pembrolizumab in Patients With Relapsed/Refractory Hodgkin's Lymphoma
This is a single-centre, observational, prospective and exploratory study, which involves the use of human tissues from patients affected by Relapsed/Refractory classic Hodgkin Lymphoma treated with pembrolizumab at the…
- Trial name
- HL-SIP (NCT06733987)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Leukemia, Acute Myeloid Leukemia (AML)
Azacitidine + Lenalidomide Combo in the Elderly With Previously Treated AML & High-Risk MDS
The purpose of the trial is to study how the elderly patients who have previously undergone treatment for acute myeloid leukemia and high-rRisk myelodysplastic syndromes, respond to a combined treatment with azacitidine and…
- Conditions
- Leukemia, Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS)
- Trial name
- NCT01442714
- Testing
- Azacitidine, Lenalidomide
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Stanford University
Hodgkin Lymphoma
Brentuximab Vedotin in the Elderly Hodgkin Lymphoma Patients at First Relapse or With Primary Refractory Disease.
This is a single-arm, open-label, multicenter, clinical trial to evaluate the efficacy and safety of BV as a single agent in elderly patients at first relapse or with primary refractory HL.
- Trial name
- FIL_BVHD01 (NCT02227433)
- Testing
- Brentuximab Vedotin
- Where
- 6 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Non Small Cell Lung Cancer (NSCLC)
Single Arm on the Tolerability of Weekly Nab-paclitaxel
The purpose of this study is to evaluate the safety and efficacy of weekly nab-paclitaxel for a second-line treatment in elderly subjects, 70 years of age or greater, with non-small cell lung cancer (NSCLC)
- Trial name
- NCT01702844
- Testing
- Nab-Paclitaxel
- Where
- 8 sites in United States
- Volunteers
- 42 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Myeloid Leukemia
A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous Leukemia.
In this ALFA-9803 trial in AML patients aged 65 years or more, we randomly compared idarubicin or daunorubicin throughout the study (first randomization) and two different post-remission strategies (second randomization): one…
- Trial name
- NCT00363025
- Testing
- Two post-remission strategies, Idarubicin versus daunorubicin
- Where
- 13 sites in France
- Volunteers
- 465 people
- Sponsor
- Acute Leukemia French Association
Stomach Neoplasms
S-1 vs Capecitabine in the Elderly and/or Poor Performance Status Patients With Recurrent or Metastatic Gastric Cancer
This study is an open-label, single-center, and randomized phase II study designed to evaluate each efficacy and safety of S-1 and capecitabine in the elderly and/or poor performance status patients with recurrent or metastatic…
- Trial name
- NCT00580359
- Testing
- S-1, capecitabine
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- National Cancer Center, Korea
Gastric Cancer
Phase I/II Study of Oral S-1 Plus Docetaxel in Elderly Patients With Advanced Gastric Cancer.
To assess the usefulness of Docetaxel plus S-1 combination chemotherapy based on the antitumor effect and survival period by performing a phase I/II study of this combination in Elderly patients with inoperable or with…
- Trial name
- NCT00209729
- Testing
- Taxotere, TS-1
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Hokkaido Gastrointestinal Cancer Study Group
Esophagus Cancer, Esophagogastric Junction Cancer
Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01
Ratiotherapy alone is the current standard treatment for elderly esophageal or esophagogastric cancer in China. And Little is known about chemoradiotherapy (CRT) in elderly patients.
- Conditions
- Esophagus Cancer, Esophagogastric Junction Cancer, Radiotherapy; Complications, Chemoradiation
- Trial name
- NCT02979691
- Testing
- SIB-IMRT, S-1
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Chinese Academy of Medical Sciences
Malnutrition
Early Detection of Malnutrition in Oncology Patients and Elderly Patients
The project is a national, prospective, multicenter, non-interventional pilot project of malnutrition screening in the Czech Republic.
- Trial name
- MALNUTRITION (NCT06499623)
- Testing
- Blood test, Bioelectrical Impedance Analysis, Nutritional Risk Assessment Questionnaire
- Where
- 9 sites in Czechia
- Volunteers
- 1,264 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Diffuse Large B Cell Lymphoma
ZR2 Followed by Immunochemotherapy in Elderly Patients With Newly-diagnosed DLBCL
As the most common subtype of lymphoma, diffuse large B-cell lymphoma (DLBCL) is an aggressive but potentially curable malignancy.
- Trial name
- NCT05290090
- Testing
- Rituximab, Lenalidomide, Zanubrutinib and RCHOP
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Zhejiang Cancer Hospital
Acute Myeloid Leukemia
Venetoclax and Azacitidine for Non-Elderly Adult Patients With Acute Myeloid Leukemia
This study aims to treat non-elderly adult patients, who were previously untreated for acute myeloid leukemia, using venetoclax and azacitidine.
- Trial name
- NCT03573024
- Testing
- Azacitidine, Venetoclax
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Cancer
Health Status Evaluation for Cancer Survivors by Non-intrusive Sensing System
To improve quality of life of elderly cancer survivors 1. Using physical activity and environmental sensing technology 2. Monitoring physiological indicators of cancer recurrence Analyzing the patient's circadian rhythm, frailty…
- Trial name
- NCT02175823
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sarcopenia, Cancer
Effect of Oral Protein Supplementation on Postoperative Complications in Elderly Sarcopenic Cancerous Patients
Sarcopenia is a condition of reduced skeletal muscle associated with aging. It leads to poor outcome and increased risk of postoperative complications.
- Trial name
- NCT04306562
- Testing
- enteral nutrition supplement
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Gastric (Stomach) Cancer, Frailty
Skeletal Muscle Mass Used to Assess Frailty in Older Gastric Cancer Patients
The primary aim of this study was to quantify the diagnosis of pre-surgical skeletal muscle mass in elderly gastric cancer patients and to analyse its correlation with frailty.
- Conditions
- Gastric (Stomach) Cancer, Frailty, Sarcopenia, Malnutrition Elderly
- Trial name
- NCT06763068
- Testing
- Skeletal muscle mass and frailty
- Where
- China
- Volunteers
- 575 people
- Sponsor
- Nanjing Medical University
Cancer
A Geriatric Assessment Electronic Platform for Older Patients With Cancer (eGAP - Electronic Geriatric Assessment Platform)
This project assesses the feasibility and usability of the geriatric assessment platform (electronic Geriatric Assessment Platform or eGAP in 50 older patients with cancer, their caregivers, and their oncology team.
- Trial name
- eGAP (NCT04824859)
- Testing
- Behavioral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Rochester
Postoperative Delirium
The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients
This study is a prospective, randomized, controlled trial.The selected patients were randomly divided into remazolam general anesthesia group and propofol + midazolam general anesthesia control group according to computer…
- Trial name
- NCT05466279
- Testing
- remazolam, Propofol, Midazolam
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Fang Jun
B-Cell Chronic Lymphocytic Leukemia
Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)
The purpose of this study is to determine the safety and efficacy of lenalidomide as a first line therapy in treating patients with B-cell Chronic Lymphocytic Leukemia.
- Trial name
- ORIGIN (NCT00910910)
- Testing
- Lenalidomide, Chlorambucil
- Where
- 165 sites in United States, Australia and 25 more
- Volunteers
- 450 people
- Sponsor
- Celgene
Colonoscopy, Colorectal Cancer Screening
Water Exchange Colonoscopy in Elderly Patients
Colonoscopy is an important test for detecting colorectal polyps and cancer, but it can cause pain and discomfort, especially in older adults. Traditional colonoscopy uses air to expand the colon.
- Trial name
- NCT07830823
- Testing
- Water exchange colonoscopy, Gas insufflation colonoscopy, Propofol and opioid anesthesia
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First People's Hospital Of Lin'an District, Hangzhou
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