Clinical trials: Geriatric Cancer Patients
Lymphoma, Mantle-Cell
Induction Chemotherapy (R-CHOP Vs. R-FC) Followed by Interferon Maintenance Versus Rituximab Maintenance in MCL
The aim of this study is to answer the following independent questions in the treatment of mantle cell lymphomas: Can rituximab-fludarabine, cyclophosphamide (R-FC) improve the reduction of lymphoma mass compared to…
- Trial name
- MCLelderly (NCT00209209)
- Testing
- Rituximab, Cyclophosphamide, Doxorubicin
- Where
- 7 sites in Czechia, Denmark and 5 more
- Volunteers
- 570 people
- Sponsor
- European Mantle Cell Lymphoma Network
Acute Myeloid Leukemia
Phase I/II Trial: BIBF 1120 Added to Low-dose Cytarabine in Elderly Patients With Acute Myeloid Leukemia (AML)
RATIONALE: Low-dose cytarabine works in a minority of elderly patients with an acute myeloid leukemia unfit for intensive induction therapy by killing of leukemia cells.
- Trial name
- NCT01488344
- Testing
- triple kinase inhibitor BIBF1120
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- University Hospital Muenster
Lymphoma, Large-Cell, Diffuse
R-ACVBP Versus R-CHOP in Patients Aged 60-65 With Diffuse Large B-cell Lymphoma
The primary objective of this study is to evaluate the efficacy of doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (ACVBP) plus rituximab in comparison to cyclophosphamide, doxorubicin, vincristine, prednisone…
- Trial name
- NCT00135499
- Testing
- Rituximab, Doxorubicin, Cyclophosphamide
- Where
- 8 sites in Belgium, France and 1 more
- Volunteers
- 138 people
- Sponsor
- Lymphoma Study Association
Newly Diagnosed Acute Myeloid Leukemia (AML), Elderly Patients
Venetoclax-Azacitidine in Combination With Chidamide and CAG in Fit Older Patients With Acute Myeloid Leukaemia
This study is a multicenter, prospective, randomized, controlled clinical trial, observing the efficacy and safety of the CACAG+Venetoclax regimen (Chidamide + Azacitidine + Aclarubicin + Cytarabine + Recombinant Human…
- Trial name
- NCT07514936
- Testing
- the standard "3+7" regimen, Azacytidine; Cytarabine; Aclacinomycin; Chidamide; Venetoclax; Granulocyte
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Lymphoma, Refractory B-Cell Lymphoma
Study of CAR-T Therapy in Older Patients
This study is being done to find out how older patients respond to CAR-T cell therapy and how the treatment affects their quality of life.
- Conditions
- Lymphoma, Refractory B-Cell Lymphoma, Lymphoma, B-Cell, DLBCL NOS
- Trial name
- NCT04300998
- Testing
- Activities of Daily Living/ADLs, Instrumental Activity of Daily Living, Timed Up and Go
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia
A Randomized Study of Gemtuzumab Ozogamicin (GO) With Daunorubicine and Cytarabine in Untreated Acute Myeloid Leukemia (AML) Aged of 50-70 Years Old
The main objective of this study is to compare conventional chemotherapy: daunorubicin and the Aracytine and this chemotherapy in combination with the monoclonal antibody used Mylotarg in divided doses.
- Trial name
- NCT00927498
- Testing
- conventional chemotherapy (AraC + Daunorubicin),, Mylotarg associated with conventional chemotherapy (AraC + Daunorubicin),
- Where
- 19 sites in France
- Volunteers
- 280 people
- Sponsor
- Acute Leukemia French Association
Rectal Tumors, Tumor of Sigmoid Colon
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
The primary change in aging lung tissue among older people is atrophy, leading to a significant decline in ventilatory function.
- Conditions
- Rectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, Laparoscopic
- Trial name
- Dex (NCT07385898)
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 64 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Gastric Cancer, Apatinib
Apatinib as the First-Line Therapy in Elderly Locally Advanced or Metastatic Gastric Cancer
The study is to investigate the efficacy and safety of apatinib for the first-fine treatment in elderly patients with locally advanced or metastatic adenocarcinoma of stomach or gastroesophageal junction, unable or unwilling to…
- Conditions
- Gastric Cancer, Apatinib, Biomarker
- Trial name
- NCT03219593
- Testing
- Apatinib mesylate tablets
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Bengbu Medical University
Cancer, Hematologic Malignancy
Telephone OncoGériatric Followed in the Management of Elderly Patients Treated for Cancer or Haematological Malignancy
There are no recommendations and few studies on the monitoring of fragile patients in the oncological treatment, both on the organizational arrangements on its interest in the prevention of functional deterioration of the patient…
- Trial name
- TelOG (NCT02583035)
- Testing
- Nurse telephone contact
- Where
- 5 sites in France
- Volunteers
- 131 people
- Sponsor
- Centre Francois Baclesse
Hodgkin Lymphoma, Adult
Elderly Hodgkin Lymphoma Patients Treated With Chemoradiotherapy
Outcome of Hodgkin lymphoma patients over than 60 years treated by chemotherapy and/or radiotherapy: retrospective analysis.
- Trial name
- HODGSA (NCT03535948)
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Central Hospital, Nancy, France
Colorectal Neoplasms, Aged
Exercise Program for Colorectal Older Patients
The Exercise for COlorectal OLder patients (ECOOL program) is randomized controlled trial to assess the effects of an exercise program on physical function and health-related quality of life of patients 75 years and older with…
- Trial name
- ECOOL (NCT05448846)
- Testing
- Enhanced Recovery After Surgery, Home-based multicomponent exercise program (EXE)
- Where
- Spain
- Volunteers
- 252 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Colorectal Tumor
ANC1 Study Impact of a Geriatric and Nutritional Evaluation for the Malnutrition and Malnutrition Risk Screening in Patients Over 70 Years With Colorectal Surgery.
Malnutrition priori a major abdominal surgery is frequent and increases morbidity and mortality. The management of malnutrition has an impact in reducing postoperative complications.
- Trial name
- ANC1 (NCT02084524)
- Testing
- Malnutrition screening and perioperative nutritional support
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Ovarian Cancer, Surgery
PROADAPT-ovary/EWOC-2
PROADAPT is a standardized geriatric intervention that is currently being co-constructed during an exploratory phase on a multi-professional and multi-disciplinary basis after a systematic analysis of published data (Figure).
- Trial name
- NCT04284969
- Testing
- PROADAPT program
- Where
- 11 sites in France
- Volunteers
- 292 people
- Sponsor
- Hospices Civils de Lyon
Glioblastoma
A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)
There is emerging evidence that hydroxychloroquine (HCQ), a drug used commonly in the prevention/ treatment of malaria, rheumatoid arthritis and lupus erythematosus, may improve survival outcome in a variety of cancers including…
- Trial name
- HCQ (NCT01602588)
- Testing
- Hydroxychloroquine, Radiotherapy
- Where
- 15 sites in United Kingdom
- Volunteers
- 54 people
- Sponsor
- University College, London
Nasopharyngeal Carcinoma
Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
- Trial name
- NCT03058432
- Testing
- Radiotherapy alone, Concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Zhejiang Cancer Hospital
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Myelodysplastic Syndromes, Leukemia Myeloid Acute
Validation of a Comprehensive Health Status Assessment Scale in Elderly Patients (≥ 65 Years) With Hematological Malignancies
The elderly comprise the most prevalent population in oncology practice. The available evidence suggests that old patients are undertreated patients, mainly because of their advanced age, regardless of whether they are highly…
- Conditions
- Myelodysplastic Syndromes, Leukemia Myeloid Acute, Multiple Myeloma, Leuklemia, Lymphocytic, Chronic
- Trial name
- GAH (NCT02164071)
- Testing
- Geriatric Assessment of Health Status Scale administration
- Where
- 22 sites in Spain
- Volunteers
- 363 people
- Sponsor
- Celgene
Chronic Myeloid Leukemia
Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy
Standard therapy with Imatinib (IM) significantly prolongs the survival of Ph+CML patients who obtain a complete cytogenetic response (CCgR).
- Trial name
- INTERIM0407 (NCT00858806)
- Testing
- Imatinib
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Università degli Studi di Brescia
Lung Neoplasm, Thoracic Surgical Procedures
Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients
This multicenter prospective clinical study focuses on elderly patients with lung cancer. The investigators will build a standardized clinical registry database, develop perioperative risk stratification and surgical…
- Conditions
- Lung Neoplasm, Thoracic Surgical Procedures, Perioperative Care, Postoperative Rehabilitation
- Trial name
- NCT07632664
- Testing
- Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling, Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling, Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Acute Myeloid Leukemia
Efficacy Study of Oral Sapacitabine to Treat Acute Myeloid Leukemia in Elderly Patients
The objective is to treat elderly AML and MDS patients with sapacitabine.
- Trial name
- NCT00590187
- Testing
- Sapacitabine, Arm A, Sapacitabine, Arm B, Sapacitabine, Arm C
- Where
- 15 sites in United States
- Volunteers
- 105 people
- Sponsor
- Cyclacel Pharmaceuticals, Inc.
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