Clinical trials: Geriatric Depression
Diabetic Retinopathy
Collaborative Care for Depression and Diabetic Retinopathy in African Americans
In this feasibility/pilot study, we will develop, refine, and evaluate the feasibility of a novel mental health/ophthalmologic intervention called, "Collaborative Care for Depression and Diabetic Retinopathy" (CC-DDR), which aims…
- Trial name
- CC-DDR (NCT02121340)
- Testing
- Behavioral Activation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Caregiver Burden, Depression
Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia
The Sharing History through Active Reminiscence and Photo-imagery (SHARP) Program engages triads (primary caregiver, person living with dementia, caregiver support person) in walking and social reminiscence, using a group tablet…
- Conditions
- Caregiver Burden, Depression, Cognitive Impairment
- Trial name
- SHARP-CG (NCT05658328)
- Testing
- SHARP - Physical and social activity
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Quality of Life, Depression
Group Drumming for Improving the Health of Community-Dwelling Elderly
The study seeks to examine the effects that recreational group drumming has on the health of the community- dwelling elderly. It is hypothesized that it has positive and sustainable effects on various health outcome measures.
- Conditions
- Quality of Life, Depression, Sleep, Blood Pressure
- Trial name
- NCT06489834
- Testing
- Group Drumming
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Major Depression
Safety, Tolerability and Efficacy of the Transdermal System in Elderly Subjects With Major Depression
Objective of this 16-week, open-label study is to assess the safety and tolerability of once daily application of three doses of STS during continuous dosing in the treatment of elderly subjects with major depression.
- Trial name
- NCT00285766
- Testing
- Selegiline Transdermal System
- Where
- 15 sites in United States
- Volunteers
- 300 people
- Sponsor
- Somerset Pharmaceuticals
Treatment Resistant Depression, Elderly Depression (≥65y.o.)
Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment
This trial aims at testing a new intensive, personalized functional targeting, transcranial magnetic stimulation technique for elderly patients (aged ≥ 65 years) suffering from a current treatment resistant depressive episode to…
- Trial name
- OLDEP-TBS (NCT07188753)
- Testing
- transcranial magnetic stimulation by accelerated & high-dose theta-burst, functional imaging guided, i
- Volunteers
- 186 people
- Sponsor
- Rennes University Hospital
Loneliness, Geriatric Depression
Applying a Chatbot to Geriatric Patients in Psychiatric Clinics: A Pilot Study
This study will use the caring chatbot developed by the Taipei University of Technology team to provide care for participants and use robots to talk to them to collect daily changes in mood, sleep, and activities, and analyze the…
- Trial name
- NCT05054660
- Testing
- caring chatbot
- Volunteers
- 75 people
- Sponsor
- Chang Gung Memorial Hospital
Early Onset Alzheimer Disease, Mild Cognitive Impairment
Reference Database & Longitudinal Registry of the Normal and Pathological Aging Brain
Establishment of a BNA reference database for the Adult and Elderly Population. Hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between clinical…
- Conditions
- Early Onset Alzheimer Disease, Mild Cognitive Impairment, Depression, Aging
- Trial name
- (BNA™) (NCT02875496)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Depressive Disorder
An Eight-week Study Evaluating the Efficacy of a 100mg Dose of Saredutant Once Daily, in Elderly Patients With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy of saredutant in the treatment of Major Depressive Disorder in elderly patients.To evaluate the tolerability, safety and efficacy on disability and quality of life in patients…
- Trial name
- NCT00415142
- Testing
- saredutant (SR48968), escitalopram
- Where
- 8 sites in United States, Croatia and 6 more
- Volunteers
- 393 people
- Sponsor
- Sanofi
Depression in Old Age
Reaching and Engaging Depressed Senior Center Clients
The purpose of this study is to test the feasibility of one type of therapy session, Virtual Augmented Engage (Engage-A). The research is being done because the researchers are trying to learn if these approaches could be used by…
- Trial name
- REDS II (NCT04289298)
- Testing
- Engage-A, Training and utilizing Engage-A therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Weill Medical College of Cornell University
Aging, Nursing Homes
Effect of Sunlight Exposure and Outdoor Activities on Depression, Cognition and Quality of Life in the Elderly
Background: The transition to long-term care facility can be a stressful and emotional event for the elderly. The evidences showed that the prevalence of depression and the cognition impairment were higher in the…
- Conditions
- Aging, Nursing Homes, Depression in Old Age, Cognitive Impairment
- Trial name
- NCT03304301
- Testing
- sunlight exposure
- Where
- Taiwan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Depressive Disorder
Validity of the 3-item Patient Health Questionnaire (PHQ-3) for Identifying Moderate-to-Severe Depressive Symptoms Among Elderly Perioperative Patients: A Secondary Analysis of a National Prospective Cohort
This is a retrospective observational study based on our hospital's prospective peri-operative elderly patient database. We aim to evaluate the correlation between the 9-item Patient Health Questionnaire (PHQ-9) and the brief…
- Trial name
- NCT07818057
- Testing
- Retrospective data analysis
- Where
- China
- Volunteers
- 10,536 people
- Sponsor
- Chinese PLA General Hospital
Depression, Mild Cognitive Impairment
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to rapidly improve symptoms in depression.
- Trial name
- NCT06069843
- Testing
- IV Ketamine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression, Depressive Symptoms
Meru Health Ascend Mobile Intervention for Depression in Middle Aged and Older Adults
Using technology to deliver depression interventions is one way could alleviate the public health burden of depression. The study is testing a mobile app intervention program for depression that uses cognitive behavioral skills…
- Trial name
- NCT03652948
- Testing
- Meru Health Ascend Program
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Palo Alto Veterans Institute for Research
Depression
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals
This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.
- Trial name
- NCT00178035
- Testing
- paroxetine, One night of Total Sleep Deprivation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Virtual Reality, Depression
Use of Virtual Reality as a Tool for Cognitive Remediation in Elderly Depressed Patients
Depression, the most common mental disorder affecting the elderly, represents a major public health issue. This pathology leads to a loss of activity and autonomy in the elderly.
- Trial name
- REVIVED (NCT07119008)
- Testing
- Virtual reality
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Major Depressive Disorder
Treatment Resistant Geriatric Depression in Primary Care
This study involves collaboration between McLean Hospital, Geriatric Medicine at the Cambridge Health Alliance (CHA) and other sites within the Partners and Harvard Medical School network.
- Trial name
- NCT01392287
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Dementia
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in…
- Conditions
- Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression
- Trial name
- ONR (NCT05531591)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 4 sites in United States, Canada
- Volunteers
- 87 people
- Sponsor
- Centre for Addiction and Mental Health
Depression Anxiety Disorder, Geriatric Diseases
A Tripartite Biopsychosocial Intervention Program Enhances Mental Health and Quality of Life in Elderly Patients With Depression Secondary to Geriatric Diseases
The biopsychosocial integrated intervention program is an effective model for improving holistic health in elderly patients with geriatric disease-related secondary depression, significantly alleviating depressive symptoms…
- Conditions
- Depression Anxiety Disorder, Geriatric Diseases, Mental Health and Quality of Life in Elderly Patients
- Trial name
- NCT07002385
- Testing
- control group, Intervention group
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Wenzhou Seventh People's Hospital
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware