Clinical trials: Geriatric Depression
Treatment Resistant Depression
Deep Brain Stimulation to Relieve Depression
This is an open label study with a sample size of 6 to develop deep brain stimulation of the subcallosal cingulate white matter(SCCWM) for late life depression using an experimental medicine approach in which the investigators…
- Trial name
- DRIVER (NCT02889250)
- Testing
- Medtronic Activa SC DBS, Lead Model 3387
- Sponsor
- Jordan F. Karp
Depression, Elderly
Collaborative Care for Depressed Elderly in Korea
Late-life depression is associated with physical limitations, greater functional impairment, increased utilization and cost of health care, and suicide.
- Conditions
- Depression, Elderly, Korean, Collaborative Care
- Trial name
- NCT01626716
- Testing
- care management
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- National Clinical Research Coordination Center, Seoul, Korea
Hiv, Depression in Old Age
Creating a Virtual Village for People Aging With HIV During COVID-19
In a PCORI-funded project on HIV and aging engagement that was co-led by the study team, the topics of isolation and depressions were identified as priority areas of deep concern among older PLWH.
- Conditions
- Hiv, Depression in Old Age, Isolation, Social, Aging
- Trial name
- NCT04747756
- Testing
- Virtual Village
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Depression, Anxiety
Online Culture for Mental Health in People Aged 16-24
O-ACE POP is a randomised controlled trial of an online cultural experience named Ways of Being, compared to a typical museum website (the Ashmolean Museum).
- Trial name
- O-ACEPOP (NCT04663594)
- Testing
- WofB, Ashmolean Website
- Where
- United Kingdom
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Resistance Exercise, Muscle Weakness
Effects of Elastic Band Resistance Exercise on Muscle Strength and Depression in Hospitalized Elderly.
With improved a five-day intensive, low-resistance elastic band exercise program to evaluate its effectiveness in improving total muscle mass, upper and lower extremity muscle strength, self-perceived fear of falling, and…
- Conditions
- Resistance Exercise, Muscle Weakness, Functional Decline
- Trial name
- NCT06205147
- Testing
- Elastic Band
- Where
- Taiwan
- Volunteers
- 62 people
- Sponsor
- National Taiwan University
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-068)(COMPLETED)
A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression.
- Trial name
- NCT00035048
- Testing
- aprepitant
- Volunteers
- 540 people
- Sponsor
- Merck Sharp & Dohme LLC
Depressive Disorder, Major
A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)
The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin reuptake inhibitor [SSRI] or serotonin and…
- Trial name
- VENTURA-LT (NCT05518149)
- Testing
- Aticaprant
- Where
- 234 sites in United States, Argentina and 19 more
- Volunteers
- 871 people
- Sponsor
- Janssen Research & Development, LLC
Major Depression
Duke Conte Center for the Neuroscience of Depression in Late Life
The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis.
- Trial name
- NCT00576875
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Transcranial Magnetic Stimulation, Depressive Disorder, Major
Accelerated Bilateral rTMS on Geriatric Depression
This study aims to evaluate the efficacy of accelerated bilateral repetitive transcranial magnetic stimulation (rTMS) on major depression, anxiety, cognitive function and physiological parameters in elderly depressive patients.
- Trial name
- NCT04486222
- Testing
- Repeated Transcranial Magnetic Stimulation
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- National Taiwan University Hospital
Depression
Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth
This study will assess the effects of moderate vs. high intensity aerobic exercise, performed 3 times a week for 12 weeks under supervised conditions, on symptoms of depression, cognitive functioning and brain function in…
- Trial name
- NCT04110041
- Testing
- Aerobic Exercise
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Royal's Institute of Mental Health Research
Suicidal Ideation, Depression
Gamified VR Sports for Elderly Suicidal Ideation
Detailed Description: This quasi-experimental study investigates the effectiveness of a gamified sports exercise intervention delivered through virtual reality (VR) to improve mental health and life expectancy in elderly…
- Conditions
- Suicidal Ideation, Depression, Mental Health Issue
- Trial name
- VR-LIFE-SI (NCT06856083)
- Testing
- Gamified Virtual Reality Sports Exercise Program, Traditional Sports Exercise Program for Elderly Individuals with Suicidal Thoughts
- Where
- Iran
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Major Depressive Disorder
Magnetic Randomized Trial in Elderly Depressed
Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited for issues such as refractoriness, adverse effects and drug interactions, especially in the elderly…
- Trial name
- MrTED (NCT04842929)
- Testing
- Transcranial magnetic stimulation
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- University of Sao Paulo
Depression
Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression
Depressed subjects display a cognitive bias of information processing and emotional self-regulation, which reinforces negative experiences more than positive ones, known as the negativity bias.
- Trial name
- MusInDep (NCT05143983)
- Testing
- Positive valence music, Neutral valence music
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Suicide
Cognitive Inhibition, Psychosocial Interactions and Suicide Attempt in Elderly
The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.
- Trial name
- OBSUIVAL (NCT02858427)
- Testing
- eye tracking, neuropsychological assessement, psychiatric assessment
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Major Depressive Disorder, Neuroticism
Predictors of Cognitive Outcomes in Geriatric Depression
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging.
- Conditions
- Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
- Trial name
- NBOLD (NCT05273996)
- Testing
- Sertraline, bupropion, desvenlafaxine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- David Steffens