Clinical trials: Geriatric Depression
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 2
Deficits in cognitive control are core features of late-life depression, contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND2 (NCT04433767)
- Testing
- Transdermal Nicotine patch
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Major Depressive Disorder
Reward Function and Therapy for Late-Life Depression
The goal of this study is to learn about changes in the brain that occur during Engage, a psychotherapy for depression in older adults, and how they may differ from changes that occur during supportive therapy.
- Trial name
- NCT03688139
- Testing
- Engage Therapy, Supportive Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Weill Medical College of Cornell University
Treatment Resistant Depression, Major Depressive Disorder
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults
The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD).
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Treatment-Refractory Depression, Late Life Depression
- Trial name
- OPTIMUM (NCT02960763)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 5 sites in United States, Canada
- Volunteers
- 742 people
- Sponsor
- Washington University School of Medicine
Aging, Depression
Cognitive Enhancement in Depression (The COG-D Study)
This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of computerized cognitive training in older adults with recurrent depression (2 or more lifetime episodes; either current or…
- Conditions
- Aging, Depression, Cognitive Symptom
- Trial name
- NCT05400512
- Testing
- Cognitive Training, tDCS (active stimulation)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Bipolar Depression
CoQ10 in Geriatric Bipolar Depression
We propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults. We would also like to investigate changes in brain energy metabolites and in vivo creatine kinase (CK)…
- Trial name
- CoQ10 (NCT00720369)
- Testing
- CoEnzyme Q10
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Dysthymic Disorder
Duloxetine Treatment in Elderly With Dysthymia
Dysthymic disorder (DD) denotes chronic depression with fewer symptoms than major depressive disorder (MDD), and it affects ~ 2-4 % of adults with a similar prevalence in the elderly.
- Trial name
- NCT01852383
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder, Major
A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)
The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin reuptake inhibitor [SSRI] or serotonin and…
- Trial name
- VENTURA-LT (NCT05518149)
- Testing
- Aticaprant
- Where
- 234 sites in United States, Argentina and 19 more
- Volunteers
- 871 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder
Efficacy and Safety Study of Seroquel SR in the Treatment of Major Depressive Disorder
The primary purpose of this study is to evaluate whether treatment with (SEROQUEL SR) quetiapine fumarate sustained release (SR) for 9 weeks compared to placebo will improve depressive symptoms in elderly patients with major…
- Trial name
- NCT00388973
- Testing
- Quetiapine
- Where
- 43 sites in United States, Argentina and 4 more
- Volunteers
- 338 people
- Sponsor
- AstraZeneca
Major Depressive Disorder
Magnetic Resonance Imaging Study of Geriatric Depression
The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression.
- Trial name
- NCT00245557
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depressive Disorder, Treatment-Resistant
A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression
The purpose of this study is to evaluate the efficacy and safety of switching elderly participants with treatment-resistant depression (TRD) from a prior antidepressant treatment (to which they have not responded) to either…
- Trial name
- TRANSFORM-3 (NCT02422186)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral Antidepressant)
- Where
- 69 sites in United States, Belgium and 10 more
- Volunteers
- 139 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder
Connectivity Affecting the Antidepressant REsponse Study
It can be difficult to achieve remission in individuals with late-life depression (LLD) and they often require aggressive treatment. This challenge is in part due to age-related vascular changes that are common in LLD.
- Trial name
- CAARE (NCT02332291)
- Testing
- Escitalopram, Bupropion XL
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain, Depression
A Behavioral Intervention for Depression and Chronic Pain in Primary Care
Chronic pain and depression frequently co-exist in late and mid-life and contribute to increased disability, high health care costs, psychiatric comorbidity, and suicide.
- Trial name
- Relief (NCT03265210)
- Testing
- RELIEF
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Weill Medical College of Cornell University
Depression
The PACE/PACENET Behavioral Health Laboratory Project
The purpose of the current project is to conduct a program evaluation that examines the impact of the The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program - a telephone-based clinical service designed to…
- Trial name
- SUSTAINII (NCT02440594)
- Testing
- Enhanced BHL Program Services, Standard BHL Program Services
- Where
- United States
- Volunteers
- 2,432 people
- Sponsor
- University of Pennsylvania
Depression
Treatment Response of Geriatric Depression
The purpose of this study is to examine the relationship between brain electrical activity in elderly depressed patients and response to antidepressant medication treatment.
- Trial name
- ERP (NCT00754936)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Pain, Respiratory Depression
Study of Respiratory Depression When Using a Hydromorphone Pain Protocol
This is a study about the efficiency and safety of a 1mg+1mg hydromorphone pain management protocol for the treatment of moderate to sever pain in the Emergency Department.
- Trial name
- NCT01784991
- Testing
- Hydromorphone, Usual care group
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Albert Einstein Healthcare Network
Depression
Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression
This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant medication alone.
- Trial name
- NCT00177294
- Testing
- Escitalopram, Interpersonal Psychotherapy, Clinical Monitoring
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- University of Pittsburgh
Bipolar Disorder, Depression, Bipolar
Lamotrigine for Symptoms of Geriatric Bipolar Depression
This is a 12-week, open label trial of lamotrigine for older adults (age 60 and older) with type I or type II Bipolar depression.
- Trial name
- Geri-BD SAD (NCT00621842)
- Testing
- Lamotrigine regular tablet formulation, Lamotrigine novel formulation
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- University Hospitals Cleveland Medical Center
Depression, Inflammation
Stress and Inflammation in Late-Life Depression
Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease.
- Trial name
- S&I (NCT02389465)
- Testing
- Escitalopram + Celecoxib
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
Vilazodone for Treatment of Geriatric Depression
The purpose of this study is to examine the effects of vilazodone for the treatment of depression in older adults.
- Trial name
- NCT01608295
- Testing
- Vilazodone; Viibryd, Paroxetine; Paxil
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles