Clinical trials: Geriatric Diseases
Hypovitaminosis D
A Study on Oral Vitamin D Megadoses
The purpose of this study is to determine if infrequent administration of oral vitamin D megadoses is effective treatment to maintain serum 25-hydroxyvitamin D(3) above target levels of 50-75 nmol/L.
- Trial name
- NCT01067898
- Testing
- vitamin D3 (cholecalciferol), olive oil, calcium carbonate
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Hand, Foot, and Mouth Disease (HFMD), Enterovirus 71 Infection
Bridging Clinical Trial of EV71 Vaccine in Vietnamese Children
The purpose of this study is to evaluate the immunogenicity and safety of an inactivated Enterovirus Type 71 (EV71) vaccine, manufactured by Sinovac, in healthy Vietnamese children aged 6 to 71 months.
- Trial name
- NCT07793175
- Testing
- EV71 vaccine
- Where
- Vietnam
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Subclinical Hypothyroidism
Mechanistic Study of Subclinical Hypothyroidism In the Elderly
Subclinical hypothyroidism, defined as an elevated TSH in the setting of normal thyroid hormone levels, is a common diagnosis in the elderly.
- Trial name
- NCT02399475
- Testing
- Levothyroxine, Liothyronine, Thyrotropin-Releasing Hormone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Pennsylvania
Exhaustion, Geriatric Disorder
Nursing Follow up in Geriatric Oncology : Tracking Time of Caregiver Exhaustion Risk
In geriatric oncology, caregivers are submitted to a risk of exhaustion. To investigate the clinical risk factor of exhaustion, the researchers propose to conduct a prospective observational study during 6 months phone follow up…
- Trial name
- TANGO (NCT02551965)
- Testing
- Phone nursing follow-up
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Hypertension
National Survey on Hypertension
Describe the clinical characteristics of hypertensive patients aged of 75 years and older seen in general practitioner consultation according to their renal damage
- Trial name
- SERENITE (NCT00804167)
- Where
- 1,291 sites in France
- Volunteers
- 4,500 people
- Sponsor
- AstraZeneca
Malnutrition, Child
Chronic Malnutrition and Oral Health Status in Children Aged One to Five Years
Malnutrition is a public health problem that can exert a negative impact on the general and oral health of children. The aim of the present study was to evaluate the effect of chronic malnutrition on the oral health of children…
- Trial name
- NCT03529500
- Testing
- Caries detection - dmtf index, Saliva flow rate, Saliva Buffering Capacity
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Crohn's Disease
Study of Bacteroides Thetaiotaomicron in Young People Aged 16 to 18 Years With Stable Crohn's Disease
The purpose of this study is to assess the safety and tolerability of Bacteroides thetaiotaomicron (Thetanix®)) capsules in young people aged 16 to 18 years with stable Crohn's disease.
- Trial name
- NCT02704728
- Testing
- Thetanix
- Where
- 5 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- 4D pharma plc
Geriatric Patients, Neurological Disorder
Personalized Motor Learning in Primary Care Physiotherapy (TREAT)
Over the last decade many scientific articles have been published on motor learning in neurological and geriatric rehabilitation.
- Trial name
- NCT06390800
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zuyd University of Applied Sciences
Tuberous Sclerosis Complex (TSC), Lymphangioleiomyomatosis (LAM)
Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)
This study will evaluate the safety and efficacy of RAD001 in treating patients with Angiomyolipoma associated with Tuberous Sclerosis Complex or Sporadic Lymphangioleiomyomatosis.
- Trial name
- EXIST-2 (NCT00790400)
- Testing
- Everolimus (RAD001)
- Where
- 25 sites in United States, Canada and 9 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Dental Plaque, Dental Care
Effectiveness of Theobromine Toothpaste
Since plaque control forms the basis for caries prevention, the type of toothpaste and its constituents becomes more important. Toothpaste containing fluoride are widely popular and fluorides have been historically reported to…
- Trial name
- NCT05187507
- Testing
- Evaluation of the effectiveness of low- fluoridated toothpaste., Evaluation of the effectiveness of fluoridated toothpaste., Evaluation of the effectiveness of theobromine toothpaste (2%) toothpaste.
- Where
- Syria
- Volunteers
- 80 people
- Sponsor
- Damascus University
Epilepsy
Study of Valproate in Young Patients Suffering From Epilepsy
Main objective: Therapeutic follow-up study Evaluate the clinical and biological safety of valproate administered as microgranules, under standard prescription conditions, with therapeutic follow-up and individual dosage…
- Trial name
- VAPOP (NCT00385411)
- Testing
- valproate microgranules
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Sanofi
Obesity & Overweight, Fat Mass
High-Intensity Interval Training in Low Versus Normal Oxygen: Effects on Body Fat and Gut Health in Adults Aged 50-75 With Overweight or Obesity (HYPOXFAT)
Overweight and obesity are major public health challenges worldwide, and their prevalence increases with age, partly because of age-related metabolic and hormonal changes.
- Trial name
- HYPOXFAT (NCT07796971)
- Testing
- Hypoxic High-Intensity Interval Training, Normoxic High-Intensity Interval Training
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Lung Neoplasm, Thoracic Surgical Procedures
Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients
This multicenter prospective clinical study focuses on elderly patients with lung cancer. The investigators will build a standardized clinical registry database, develop perioperative risk stratification and surgical…
- Conditions
- Lung Neoplasm, Thoracic Surgical Procedures, Perioperative Care, Postoperative Rehabilitation
- Trial name
- NCT07632664
- Testing
- Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling, Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling, Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Epilepsy
This Study Will Assess the Etiology, Potential Risk Factors, and Seizure Types in Patients Over 50 With Epileptic Seizure Disorder, Using Laboratory Tests, EEG, and Neuroimaging Findings.
This study underscores the importance of studying the etiology, clinical characteristics, and types of epilepsy in the elderly to improve diagnosis and management in our community.
- Trial name
- NCT07026409
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Mild Cognitive Impairment
Real-time fMRI Neurofeedback in Patients With MCI
Increased activity in the hippocampus (i.e., hyperactivity) during a fMRI memory task was found in patients with Mild Cognitive Impairment due to Alzheimer's disease (MCI).
- Trial name
- NCT04020744
- Testing
- real-time fMRI based neurofeedback from the hippocampus, real-time fMRI based neurofeedback from another brain area
- Where
- 2 sites in Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Bern
Acute Kidney Injury
Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement
Total hip arthroplasty refers to the replacement of the femoral head and acetabulum damaged by disease or trauma with an artificial hip joint, thereby restoring joint activity and original function.
- Trial name
- NCT04132921
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xuzhou Medical University
Frailty Syndrome, COVID-19
Implementation of the Integrated Care of Older People App and ICOPE Monitor in Primary Care (ICOPE)
Introduction: The World Health Organization has launched the INSPIRE-ICOPE-CARE program towards healthy aging. It includes "intrinsic capacity", defined as "the composite of all the physical and mental capacities of an…
- Conditions
- Frailty Syndrome, COVID-19, Healthy Aging, Old Age; Debility
- Trial name
- ICOPE (NCT04413877)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Liege
Heart Failure, Preserved Ejection Fraction
Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF
HFpEF has a high incidence and lacks effective therapy, and its onset is closely related to systemic inflammation and intestinal dysbacteriosis.SGLT-2i exerts its effects by diuresis, anti-inflammatory and improving energy…
- Trial name
- NCT07687212
- Testing
- Henggliflozin Combined with Probiotics, Henggliflozin
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The First Affiliated Hospital of Air Force Medical University
Diabetic Polyneuropathy
Differential Air Pressure Technology for Treatment of Diabetic Elderly Patients
Aging can be defined as sequential deterioration that occurs in elderly people including weakness, loss of mobility, decline of physical capabilities, increase susceptibility to disease and many other age-related physiological…
- Trial name
- NCT04620265
- Testing
- Antigravity treadmill training 100% weight bearing, Antigravity treadmill training 75% weight bearing, Antigravity treadmill training 50% weight bearing
- Where
- Saudi Arabia
- Volunteers
- 110 people
- Sponsor
- Umm Al-Qura University
Herpes Zoster
Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine With Various Formulations in Adults >= 50 Years
The goal of this randomized observer-blind trial is to further refine the formulation of vaccines containing GSK1437173A in older adults by comparing the cellular and humoral immune responses and the safety profiles of the…
- Trial name
- NCT00802464
- Testing
- Herpes zoster vaccine GSK1437173A
- Where
- 12 sites in United States, Czechia and 1 more
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline