Clinical trials: Geriatric Disorders
Acute Myeloid Leukemia (AML)
Treatment of Elderly AML Patients With Induction Chemotherapy Followed by G-CSF-Mobilized Stem Cells From Haploidentical Related Donors
The purpose of this study is to test a method of bone marrow transplantation that results in only temporary donor immune function.
- Trial name
- NCT02519712
- Testing
- Induction Chemotherapy, G-PBSC Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Familial Hypercholesterolaemia
An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial Hypercholesterolaemia
This study is being carried out to see if the study medication, rosuvastatin, is effective in treating familial hypercholesterolaemia in children and adolescents, and to determine the long term (over 2 years) safety, tolerability…
- Trial name
- NCT01078675
- Testing
- rosuvastatin calcium
- Where
- 15 sites in United States, Belgium and 3 more
- Volunteers
- 315 people
- Sponsor
- AstraZeneca
Protein Deficiency, Training Group, Sensitivity
Effects of a Recovery Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing
The investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.
- Conditions
- Protein Deficiency, Training Group, Sensitivity, Fatigue, Muscular Atrophy
- Trial name
- NCT05769101
- Testing
- Ingestion of a Post-Workout Supplement, Ingestion of a Maltodextrin Supplement
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joel Puente
Malaria, Severe Anemia
Post-discharge Malaria Chemoprevention(PMC) Study
This study evaluates the efficacy and safety of 3 months of malaria chemoprevention post-discharge using dihydroartemisinin piperaquine (DHA-P) in children under 5 years of age admitted with severe anemia.
- Trial name
- PMC (NCT02671175)
- Testing
- dihydroartemisinin-piperaquine
- Where
- 9 sites in Kenya, Uganda
- Volunteers
- 1,049 people
- Sponsor
- Liverpool School of Tropical Medicine
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Pain, Acute, Child Behavior
The Effect of "Quantum-Touch" on Pain, Fear, and Anxiety of the Children
This research is a randomized controlled experimental study designed to determine the effect of the Quantum-Touch method applied during the vascular access procedure in children aged 7-12 years, on the level of pain, fear and…
- Conditions
- Pain, Acute, Child Behavior, Anxiety and Fear, Venipuncture Site Reaction
- Trial name
- NCT05828264
- Testing
- Quantum touch
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Trakya University
Attention Deficit Hyperactivity Disorder (ADHD)
A Random Controlled Trial of Home-based Digital Therapy for Treating ADHD in Children
Explore the interventional effects of neurofeedback games on school-aged children with mild to moderate ADHD, with the aim of providing evidence-based new methods for intervening in the core symptoms of ADHD in children.
- Trial name
- NCT07552909
- Testing
- Home-based digital therapy with brain-controlled games
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Prostate Cancer, Survivorship
Health Status, Quality of Life and Function in Survivors After Radical Treatment for Prostate Cancer. Part IIB
The present study is the last part of a larger project investigating the health, quality of life and function of men having received radical treatment for prostate cancer in 2014-2018.
- Conditions
- Prostate Cancer, Survivorship, Physical Function, Physical Activity
- Trial name
- OPSIIB (NCT05200039)
- Where
- Norway
- Volunteers
- 109 people
- Sponsor
- Sykehuset Innlandet HF
Influenza, Human
A Study to Assess the Safety and Immune Response of Quadrivalent Seasonal Influenza Vaccine (Fluarix Tetra) in Participants Aged 65 Years and Older in India
The purpose of this study is to gather additional evidence of the safety and immunogenicity of 1 dose of Fluarix Tetra (0.5 milliliter [mL]) (Northern Hemisphere (NH)2023-2024) in individuals aged 65 years and above to fulfill a…
- Trial name
- NCT05648357
- Testing
- Fluarix Tetra Vaccine
- Where
- 6 sites in India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Metabolic Syndrome
Trial of Supplementation With Aged Garlic Extract to Improve Endothelial Function in Patients With Metabolic Syndrome
Many studies have addressed the relationship between metabolic syndrome and cardiovascular disease. Risk factors include abdominal obesity, insulin resistance, abnormal lipid profile and hypertension.
- Trial name
- Kymes (NCT01168700)
- Testing
- aged garlic extract
- Where
- Colombia
- Volunteers
- 46 people
- Sponsor
- Universidad de Santander
Dysphagia
The Impact of Intermittent Nutritional Tube Supplementation in Elderly Patients With Dysphagia
This is a prospective, randomized controlled clinical trail involved Elderly Patients With Dysphagia.The goal of this clinical trial is to compare the clinical effect of Intermittent Oro-esophageal Tube Feeding in Elderly…
- Trial name
- NCT06362109
- Testing
- Routine rehabilitation, Intermittent Oro-esophageal Tube Feeding
- Volunteers
- 80 people
- Sponsor
- Zhao Song Ling
Esophageal Squamous Cell Carcinoma (ESCC)
Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma
The goal of this clinical trial is to assess the percentage of patients alive at 6 months in elderly patients, not eligible to an platinum-based chemotherapy, but who can received the Tislelizumab treatment alone as first-line…
- Trial name
- SAFE ESO (NCT07205731)
- Testing
- Tislelizumab is a fully humanized monoclonal antibody specific for human PD-1
- Where
- 30 sites in France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypertension,Essential, Hypertension
Effect of Isometric and Aerobic Physical Exercise on Blood Pressure Levels in Hypertensive Elderly People
Introduction: Adequate blood pressure control is necessary to reduce the risk of mortality from cardiovascular events. The effects of aerobic exercise on systemic arterial hypertension are already well known, however, to date…
- Trial name
- NCT06282302
- Testing
- Group control, Isometric Exercise, Aerobic Exercise
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Non-squamous Non-small-cell Lung Cancer, Cancer, Lung
Pembrolizumab Plus Pemetrexed for Elderly Patients With Non-Sq NSCLC With PD-L1 < 50%: CJLSG1901
To evaluate the efficacy and safety of Pembrolizumab + Pemetrexed in elderly patients with non-squamous non-small cell lung cancer with Programmed cell death (PD) -ligand1 (L1) tumor proportion score (TPS) of less than 50%.
- Trial name
- NCT04396457
- Testing
- Pembrolizumab, Pemetrexed
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- National Hospital Organization Nagoya Medical Center
Alzheimer Disease
A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease
Potentially inappropriate prescribing includes the use of medications that may no longer be necessary or that may increase the risk of harm.
- Trial name
- D-PRESCRIBE-AD (NCT05147428)
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 14,442 people
- Sponsor
- University of Massachusetts, Worcester
Cryopyrin Associated Periodic Syndrome
The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada
This study will assess the safety, tolerability and efficacy of canakinumab treatment in Canadian patient diagnosed with cryopyrin-associated periodic syndrome over a period of 18 months.
- Trial name
- NCT01105507
- Testing
- canakinumab (company code: ACZ885D)
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Anxiety, Children
The Effect of Parental Anxiety Level on the Child's Anxiety Level and Postoperative Pain in Children Undergoing Surgery.
The aim of this prospective study is to investigate whether the anxiety levels of parents of children aged 2-6 years who will undergo inguinal area surgery have an effect on the child\'s preoperative anxiety level and…
- Trial name
- NCT06404879
- Testing
- determining scores with tests
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Giresun University
Osteoarthritis, Hip, Arthropathy of Hip
Evaluation of Cemented and Cementless Fixation of Dual-mobility Hip Prosthesis in Elderly Patients With Osteoarthritis
The aim of this project is to investigate prosthesis fixation in the bone, respectively cemented and uncemented operation method of Avantage® dual-mobility acetabular cup in elderly patients, wear of the plastic in dual-mobility…
- Trial name
- NCT02404727
- Testing
- cup fixation, Avantage® Cup
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Myelodysplastic Syndromes, Leukemia Myeloid Acute
A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated in the validation of the psychometric…
- Conditions
- Myelodysplastic Syndromes, Leukemia Myeloid Acute, Multiple Myeloma, Leukemia, Lymphocytic, Chronic, B-Cell
- Trial name
- NCT02842229
- Where
- 15 sites in Spain
- Volunteers
- 117 people
- Sponsor
- Celgene
COVID-19
Influence of Nutritional Indices on the Prognosis of Patients With SARS-CoV-2 Infection
With the decline of virulence after the mutation of the SARS-CoV-2 , based on the national life and health and national development needs, the domestic SARS-CoV-2 infection epidemic prevention policy has changed, and the number…
- Trial name
- NCT05835102
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Juan Kang
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