Clinical trials: Geriatric Disorders
Major Depressive Disorder, Neuroticism
Predictors of Cognitive Outcomes in Geriatric Depression
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging.
- Conditions
- Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
- Trial name
- NBOLD (NCT05273996)
- Testing
- Sertraline, bupropion, desvenlafaxine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- David Steffens
Renal Insufficiency
Study to Assess Bemiparin Pharmacokinetics in Renal Insufficiency and in the Elderly
Open pharmacokinetic study with 5 parallel groups and two treatment phases (bemiparin 3,500 IU multiple dose and bemiparin 115 IU/kg single dose).
- Trial name
- NCT00413088
- Testing
- bemiparin
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rovi Pharmaceuticals Laboratories
Cognitive Impairment
Preoperative Survey
This study will examine preoperative concerns in older adults through the use of a self-administered questionnaire. The development of this questionnaire will involve adapting survey questions from previously validated studies…
- Trial name
- NCT05653154
- Where
- 2 sites in Canada
- Volunteers
- 264 people
- Sponsor
- University Health Network, Toronto
Preterm Labor
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals
Onset of labor in human is initiated by progesterone withdrawal. Over many decades researchers had proposed hypotheses to explain the functional withdrawal of progesterone.
- Trial name
- NCT05864066
- Volunteers
- 81 people
- Sponsor
- Assiut University
Obesity, Obese Adolescents
AKK Study in Improving Obesity and Metabolic Status in Children and Adolescents
The problem of obesity among children and adolescents is becoming increasingly serious and may affect their health in adulthood.
- Conditions
- Obesity, Obese Adolescents, Obese Children and Adolescents, Akkermansia Muciniphila
- Trial name
- NCT07593170
- Testing
- AKK
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Central South University
Hip Fracture, Elderly Patients
Hope Theory-Based Nursing Intervention After Hip Fracture Surgery
This is a randomized controlled trial to evaluate the effectiveness of a Snyder Hope Theory-based nursing intervention on elderly patients following hip fracture surgery.
- Conditions
- Hip Fracture, Elderly Patients, Postoperative Recovery, Nursing Interventions
- Trial name
- NCT07400770
- Testing
- Snyder Hope Theory-based Nursing Intervention, Standard Postoperative Care
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Institute of Orthopaedic Surgery, Taizhou No.3 People's Hospital
Cardiovascular Diseases
Does Paying Subjects to Participate in Research Improve Recruitment
Patient recruitment into clinical trials is a major challenge and the elderly, socially deprived and those with multiple co-morbidities are often under-represented.
- Trial name
- NCT03881969
- Testing
- Financial Payment of £100
- Volunteers
- 1,015 people
- Sponsor
- University of Dundee
68 Children Aged 7-10
The Effect of Storytelling With Metaphor Toys on Fear and Anxiety Levels in Children
The hospital environment is an unfamiliar environment for children, and unfamiliar people, unknown medical tools and equipment, sounds, and medical procedures in this environment can cause negative emotional states such as fear…
- Trial name
- NCT06611605
- Testing
- Storytelling with metaphor toys
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Emergencies
Optimized Acute Care for Geriatric Patients Using an Intersectoral Telemedical Cooperation Network - Around the Clock
Due to "demographic change", the composition of the population in Germany is changing. The consequence of this change is a population that is getting older on average.
- Trial name
- Optimal@NRW (NCT04879537)
- Testing
- Telemedical support
- Where
- Germany
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Atrophy, Muscular
A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days
The primary objective is to determine the pharmacokinetics, safety and tolerability of SRT2104 in healthy elderly subjects following single and 28 days dosing. The secondary objectives of the study are: 1.
- Trial name
- NCT00964340
- Testing
- SRT2104
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Respiratory Tract Infections, Influenza
Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu)
Purpose: The study null hypothesis is that vitamin D supplementation will not influence time to acute respiratory tract infection in sheltered accommodation residents.
- Trial name
- ViDiFlu (NCT01069874)
- Testing
- Cholecalciferol (Vitamin D/Vigantol oil), Miglyol oil
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Coronavirus Disease 2019 )COVID-19)
Early transfusIon of Convalescent Plasma in Elderly COVID-19 Patients. to Prevent Disease Progression.
Older age is an independent poor outcome predictor among COVID-19 hospitalized patients . Among 72,314 COVID-19 cases, case fatality rate (CFR) was 2.3% in total population, 8% in people aged 70 to 79, and 14.8% in those aged 80…
- Trial name
- LIFESAVER (NCT04374526)
- Testing
- COVID-19 Convalescent Plasma
- Where
- 3 sites in Italy
- Volunteers
- 29 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Locally Advanced Cervical Carcinoma
Decision Aid for Chemotherapy in Cisplatin-Intolerant Patients With Locally Advanced Cervical Cancer
The goal of this clinical trial is to investigate the utility and effectiveness of a decision aid in cisplatin-intolerant patients with locally advanced cervical cancer. The main questions it aims to answer are: 1.
- Trial name
- CECIL (NCT05701735)
- Testing
- CECIL Patient Decision Aid
- Where
- 3 sites in Philippines
- Volunteers
- 45 people
- Sponsor
- University of Santo Tomas Hospital, Philippines
Influenza
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Trivalent Split Virion Influenza Vaccine Fluviral™ (2013-2014 Season) in Adults Aged 18 Years and Older
The purpose of this study is to evaluate the immunogenicity, reactogenicity and safety of Fluviral™ containing the influenza strains recommended for the 2013-2014 season in adults aged 18 years and older.
- Trial name
- NCT01878825
- Testing
- Fluviral™
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Coronary Artery Disease, Microcirculation
Aged Garlic Extract Study
The primary intention of the study is to examine the effect of aged garlic extract (AGE) on the absolute change in coronary artery calcium (CAC).
- Conditions
- Coronary Artery Disease, Microcirculation, Biomarkers
- Trial name
- AGE (NCT03860350)
- Testing
- Aged Garlic Extract
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Frailty, Elderly
Frailty of Elderly With Valvular Heart Disease and the Short Term Adverse Events
Despite the rapid development of medical and nursing technology, the prognosis of valvular heart disease has been greatly improved.
- Conditions
- Frailty, Elderly, Valvular Heart Disease
- Trial name
- NCT05014750
- Testing
- None intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Dialysis, End Stage Renal Disease
Dialysis-Less Frequently In The Elderly
Thrice-weekly dialysis is the accepted standard of care for hemodialysis (HD) patients. Observational studies suggest that elderly HD patients do as well and have better quality of life with less dialysis (ie twice-weekly).
- Conditions
- Dialysis, End Stage Renal Disease, Hemodialysis
- Trial name
- D-LITE (NCT03787719)
- Testing
- Twice per week dialysis
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- Dr. Christine White
Quality of Life, Surgery
Determination of the Effect of Puzzle Use in Elderly Patients
The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and…
- Conditions
- Quality of Life, Surgery, Postoperative Confusion, Cognitive Dysfunction
- Trial name
- NCT05796830
- Testing
- Puzzle application
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Hospital Foodservice Satisfaction; Hospital Meals Satisfaction; Elderly, Nutrition, Malnutrition in Elderly, Malnutrition
A Logical Framework for Tailor-made Paradigm Shift Hospital Foodservice to Prevent Malnutrition Among Geriatric Patients in Hospitals
Hospital Food service is important for patient recovery by providing necessary aid with adequate meal consumption. Overall, hospital experience can influence patients' satisfaction for the foodservice quality.
- Trial name
- NCT04858165
- Testing
- MY GERYFS PROTOCOL
- Where
- 5 sites in Malaysia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Delirium in Old Age
Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery
Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.
- Trial name
- NCT06653465
- Testing
- Acetaminophen, Saline
- Volunteers
- 1,930 people
- Sponsor
- RenJi Hospital
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