Clinical trials: Geriatric Disorders
Anxiety Disorders, Depression
Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging
The investigators are developing and then testing whether Mindfulness-Based Stress Reduction, a group-based instruction for increasing mindfulness, reduces anxiety and depressive symptoms and improves cognitive functioning in…
- Trial name
- NCT01693874
- Testing
- MBSR, control (health education)
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Washington University School of Medicine
Diffuse Large B Cell Lymphoma
Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma
The purpose of this study is to investigate efficacy and safety of R-GemOx Versus R-miniCHOP as first-line treatment of elderly patients with Diffuse large B cell lymphoma
- Trial name
- NCT02767674
- Testing
- Rituximab, Gemcitabine, Oxaliplatin
- Where
- 6 sites in China
- Volunteers
- 258 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Prostate Cancer
Bi-Weekly Administration of Docetaxel for Older Men With Hormone Refractory Prostate Cancer
This pilot study is designed to determine the feasibility and safety of administering docetaxel at various dosing levels on a bi-weekly schedule in older men with hormone refractory prostate cancer.
- Trial name
- NCT00215709
- Testing
- docetaxel
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Geriatric Oncology Consortium
Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV)
Phase I, First-In Human Study to Evaluate Safety and Tolerability of EuRSV in Healthy Adults Aged Between 19 Years and 80 Years
Phase 1 clinical trial to evaluate the safety of RSV-1 and RSV-2 vaccines in healthy adults aged 19 to 80 years who have voluntarily given written consent to participate in this study.
- Trial name
- EuRSV (NCT06216093)
- Testing
- EuRSV
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- EuBiologics Co.,Ltd
Cystic Fibrosis
A Study to Evaluate the Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis
The purpose of this study is to evaluate the safety, tolerability and efficacy of VX-121 combination therapy in subjects with cystic fibrosis (CF).
- Trial name
- NCT03912233
- Testing
- VX-121, TEZ, VX-561
- Where
- 26 sites in United States, Germany and 3 more
- Volunteers
- 87 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Prematurity
Effects of a Parenting Skills Training Program on Maternal Self-Efficacy, Perceived Social Support, and Infant Development in Mothers of Preterm Infants Aged 6-12 Months
The goal of this clinical trial is to evaluate whether a structured parenting skills training intervention can improve maternal parenting self-efficacy, perceived social support, and infant developmental outcomes in mothers of…
- Trial name
- NCT07468435
- Testing
- Parental Skill Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medipol University
Type 2 Diabetes Mellitus (T2DM), Psychological Distress
Effectiveness of a Diabetes Self-Management Program Among Ethnic Minority Elderly in Rural Thailand
Type 2 diabetes is a serious health condition that affects many older adults from ethnic minority communities in Northern Thailand.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Psychological Distress, Hyperglycemia
- Trial name
- DSM-EME (NCT07669389)
- Testing
- Diabetes Self-Management Education (DSME) Program, Usual Care
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Taipei Medical University
Delirium
Rivastigmine in the Management of Delirium
The aim of this study is to evaluate the efficacy of an anticholinesterase treatment in patients aged 75 and over, hospitalized with delirium.
- Trial name
- confuriv (NCT01487317)
- Testing
- Rivastigmine transdermal patch
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fraility, Hypotension
The Effect of Frailty on Hypotension After Anesthesia Induction
Frailty is defined as a state of weakness resulting from a decrease in physiological reserves due to physiological changes, diseases, and/or malnutrition associated with advancing age.
- Trial name
- NCT07351552
- Volunteers
- 80 people
- Sponsor
- Selcuk University
Asthma, Healthy Participants
A Study to Compare the Pharmacokinetics (PK) of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152A (Test) or HFA-134A (Reference) in Healthy Participants Aged 18 to 55 Inclusive
The primary objective of the study is to characterize the PK of single doses of salbutamol in healthy participants delivered via an MDI containing propellant HFA-152a (test), and to compare with an MDI containing propellant…
- Trial name
- NCT06433908
- Testing
- Salbutamol HFA-152a, Salbutamol HFA-134a
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Delirium, Postoperative
The Impact of Smoking on the Prognosis of Elderly Surgical Patients
Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative…
- Trial name
- NCT06392308
- Testing
- none intervention
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Affiliated Hospital of Nantong University
Constipation, Diarrhea
Efficacy of a Dietary Supplementation With Lactobacillus Reuteri for Digestive Health in an Elderly Population
The purpose of this study is to investigate the effect of a daily supplement consisting of the probiotic bacteria, Lactobacillus reuteri, on the digestive health among persons 65 years and older.
- Conditions
- Constipation, Diarrhea, Indigestion, Reflux
- Trial name
- NCT01837940
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- Sweden
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Prevention of Infection Disease Caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
A Study of TAK-019 in Healthy Japanese Adults (COVID-19)
TAK-019 is a vaccine in development to protect people against Covid-19. The main aims of the study are to learn if TAK-019 can protect people from Covid-19 and to check for side effects from TAK-019.
- Trial name
- NCT04712110
- Testing
- TAK-019
- Where
- 2 sites in Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Takeda
Depression - Major Depressive Disorder, Cognition Disorders in Old Age
Real-world Clinical Response to Trazodone in Italy, Poland, and Romania
TRACOMDD study is a study with the intention to describe the real-world use of trazodone and the clinical response in a sub-group of patients affected by Major Depressive Disorder and Mild Cognitive impairment, by collecting data…
- Trial name
- NCT07377682
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Accidental Falls, Osteoporosis
Prevention of Falls and Its Consequences in Elderly People
Falls are an important risk factor for fragility fractures. Both are associated with the ageing process and as they rise also increase the risk of mortality, disability and dependency.
- Trial name
- PRECIOSA (NCT02617303)
- Testing
- OTAGO's exercises, COMMON PRACTICE
- Where
- 11 sites in Spain
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Dengue Fever
A Study of Dengue Tetravalent Vaccine (TDV) in Healthy Participants in Japan
Dengue fever is caused by an infection with the dengue virus. Vaccination with TDV can help prevent dengue fever. The main purpose of this study is to learn about TDV's ability to create an immune response in adults, adolescents…
- Trial name
- NCT06741683
- Testing
- TDV
- Where
- 5 sites in Japan
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Takeda
Fractures, Bone, Cardiovascular Abnormalities
Using a Remote Patient Monitoring Alert System to Improve Care
The purpose of this study is to determine the efficacy of a remote patient monitoring platform and alert system in reducing adverse events for hospitalized geriatric orthopedic trauma patients.
- Conditions
- Fractures, Bone, Cardiovascular Abnormalities, Respiratory System Abnormalities, Hemorrhage
- Trial name
- NCT02933840
- Testing
- AlertWatch
- Sponsor
- Massachusetts General Hospital
Dermatitis, Atopic
Tacrolimus Ointment Pharmacokinetics in Infants With Atopic Dermatitis
The purpose of this study is to estimate the systemic exposure to tacrolimus in infants with atopic dermatitis after repeated application of tacrolimus ointment.
- Trial name
- NCT00535691
- Testing
- Tacrolimus Ointment 0.03%
- Where
- 8 sites in Canada, Finland and 3 more
- Volunteers
- 53 people
- Sponsor
- Astellas Pharma Inc
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly
Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity
- Trial name
- CARTIER (NCT03711110)
- Testing
- Intensive cardiovascular monitoring, No intervention
- Where
- 14 sites in Spain
- Volunteers
- 514 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Influenza
Postmarketing Surveillance Study for Quadrivalent Influenza Vaccine (VaxigripTetra Inj.) in Subjects Aged 3 Years Old and Above
The objective is to describe the safety profile after 1 dose of VaxigripTetra inj. administered in subjects aged 3 years old and above under routine clinical practice.
- Trial name
- NCT05406180
- Testing
- VaxigripTetra inj.
- Where
- 10 sites in South Korea
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- Sanofi
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