Clinical trials: Geriatric Hematology
Anemia
Red Cell Mass and Plasma Volume Measurements in Elderly Men and Women With Anemia
On the basis that the clinical consequences of seemingly trivial levels of anemia are surprisingly severe, this study investigates if hemoglobin concentration accurately represents the underlying red cell mass in elderly patients…
- Trial name
- NCT01011361
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Eosinophilic Esophagitis
Efficacy and Safety Study of Reslizumab to Treat Eosinophilic Esophagitis in Subjects Aged 5 to 18 Years
This trial will study three doses of reslizumab versus placebo in children with eosinophilic esophagitis (EE). The objectives of the trial will be to study the effectiveness of reslizumab in improving the clinical signs and…
- Trial name
- NCT00538434
- Testing
- Reslizumab, Saline
- Where
- 37 sites in United States, Canada
- Volunteers
- 227 people
- Sponsor
- Ception Therapeutics
Iron Deficiency Anemia
Efficacious Iron for Iron Deficiency Anemia in Adults Aged ≥18 Years
Iron deficiency anemia (IDA) is a widespread condition affecting many people globally. Despite the many cases of IDA, there are few studies that compare the effectiveness of different types of iron supplements with a greater…
- Trial name
- NCT06303531
- Testing
- Ferrous Fumarate, Polysaccharide Iron, Ferrous Ascorbate
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Dr. Anil K. Gupta Medicine Professional Corporation
Lymphoma
Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, and vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00726700
- Testing
- pegfilgrastim, rituximab, cyclophosphamide
- Volunteers
- 109 people
- Sponsor
- Universität des Saarlandes
Hematologic Malignancy, Treatment Adherence
Improving Quality of Life in Older Patients With Frailty and Hematological Cancer Through Geriatric Assessment
The Improve study is a randomized controlled trial investigating the efficacy of adding comprehensive geriatric assessment and treatment to standard of care compared with standard of care in older, frail patients with…
- Conditions
- Hematologic Malignancy, Treatment Adherence, Treatment Complication, Frailty
- Trial name
- IMPROVE (NCT06373471)
- Testing
- Comprehensive geriatric assessment (CGA) and treatment
- Where
- Denmark
- Volunteers
- 152 people
- Sponsor
- Odense University Hospital
Leukemia, Myelodysplastic Syndromes
Low-Dose Decitabine Compared With Standard Supportive Care in Treating Older Patients With Myelodysplastic Syndrome
RATIONALE: Decitabine may help myelodysplasia cells develop into normal stem cells. It is not yet known if decitabine is more effective than standard supportive care in treating myelodysplastic syndrome.
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00043134
- Testing
- decitabine
- Where
- 46 sites in Austria, Belgium and 8 more
- Volunteers
- 220 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Malaria, Severe Anemia
Post-discharge Malaria Chemoprevention(PMC) Study
This study evaluates the efficacy and safety of 3 months of malaria chemoprevention post-discharge using dihydroartemisinin piperaquine (DHA-P) in children under 5 years of age admitted with severe anemia.
- Trial name
- PMC (NCT02671175)
- Testing
- dihydroartemisinin-piperaquine
- Where
- 9 sites in Kenya, Uganda
- Volunteers
- 1,049 people
- Sponsor
- Liverpool School of Tropical Medicine
Hypertension, Hand Grip Strength
The Effect of an Oral Nutritional Supplement on the Nutritional and Health Outcomes of the Elderly
I am conducting this research to find out if a peanut based food that is ready to use would improve the nutritional and health outcomes of the elderly when they consume it daily for 12 weeks.
- Conditions
- Hypertension, Hand Grip Strength, Body Weight, Iron Deficiency
- Trial name
- NCT06773975
- Testing
- Oral nutritional supplementation
- Where
- Ghana
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Ghana
Hematologic Malignancies
Umbilical Cord Transplantation for the Elderly Population
While cord blood transplants have been performed safely in elderly patients, many still relapse. The investigators propose to intensify the preparative regimen for this patient group in an attempt to decrease relapses, and…
- Trial name
- NCT01484470
- Testing
- StemEx
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Loyola University
Acute Myeloid Leukemia
TBF Conditioning Regimen for Haploidentical Stem Cell Transplantation in Elderly AML Patients in First Complete Remission
Acute myeloid leukemia (AML) is a serious blood cancer that mainly affects older adults. For patients who achieve their first complete remission (CR1), allogeneic hematopoietic stem cell transplantation (HSCT) may provide a…
- Trial name
- TBF-AML (NCT07563920)
- Testing
- Thiotepa, Busulfan (BU), Fludarabine
- Volunteers
- 93 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Myelodysplastic Syndromes, Leukemia Myeloid Acute
A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated in the validation of the psychometric…
- Conditions
- Myelodysplastic Syndromes, Leukemia Myeloid Acute, Multiple Myeloma, Leukemia, Lymphocytic, Chronic, B-Cell
- Trial name
- NCT02842229
- Where
- 15 sites in Spain
- Volunteers
- 117 people
- Sponsor
- Celgene
Acute Myeloid Leukemia
D-CTAG in the Treatment of Newly Diagnosed Acute Myeloid Leukemia in Elderly Patients
With the aging of society, the incidence of elderly leukemia in China has been increasing year by year. The elderly patients with Acute Leukemia have poor basal state, and there are many important organ diseases such as heart…
- Trial name
- NCT04168138
- Testing
- rhTPO
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huihan Wang
Acute Myeloid Leukemia
Extension Study With Tosedostat in Relapsed/Refractory Acute Myeloid Leukemia
The purpose of this study is to evaluate the long-term efficacy and safety profile of tosedostat in elderly patients suffering from refractory or relapsed Acute Myeloid Leukemia.
- Trial name
- NCT01180426
- Testing
- CHR-2797
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Chroma Therapeutics
Multiple Myeloma
A Prospective Study Comparing DRd With VRd-lite in Elderly Newly Diagnosed Multiple Myeloma
The purpose of the study is to compare the efficacy and safety of daratumumab, lenalidomide and dexamethasone (DRd) to that of modified bortezomib, lenalidomide and dexamethasone (VRd-lite), in terms of progression-free survival…
- Trial name
- NCT06497738
- Where
- 6 sites in China
- Volunteers
- 112 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
AML, MDS
Aza With or Without ATRA in Newly Diagnosed Unfit AML or Intermediate,High or Very High Risk MDS
This is a randomized, open-label, multicenter study to compare the efficacy and safety of AZA with or without ATRA in newly diagnosed unfit AML or Intermediate,High or Very High Risk MDS
- Conditions
- AML, MDS, Old Age; Debility, Hematologic Cancer
- Trial name
- NCT05175508
- Testing
- Azacitidine, all trans retinoic acid
- Where
- China
- Volunteers
- 180 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Leukemia, Acute Myeloid Leukemia (AML)
Azacitidine + Lenalidomide Combo in the Elderly With Previously Treated AML & High-Risk MDS
The purpose of the trial is to study how the elderly patients who have previously undergone treatment for acute myeloid leukemia and high-rRisk myelodysplastic syndromes, respond to a combined treatment with azacitidine and…
- Conditions
- Leukemia, Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS)
- Trial name
- NCT01442714
- Testing
- Azacitidine, Lenalidomide
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Stanford University
Acute Leukemias
Study of Efficacy and Safety of LDE225 in Adult Patients With Relapsed/Refractory Acute Leukemia
The study will evaluate the efficacy, safety and tolerability of two dosing schedules of LDE225 in patients with relapsed/refractory acute leukemia or elderly patients with untreated acute leukemia.
- Trial name
- NCT01826214
- Testing
- LDE225
- Where
- 23 sites in United States, Australia and 9 more
- Volunteers
- 70 people
- Sponsor
- Novartis Pharmaceuticals
Acute Myeloid Leukemia (AML), Elderly
Effectiveness of Medium-Dose Cytarabine Combined With Venetoclax for Consolidation Therapy in Elderly Patients With Intermediate to High-Risk Acute Myeloid Leukemia
A Single-center, Single-arm, Prospective Clinical Study of Intermediate-dose Cytarabine in Combination with Venetoclax for Consolidation Therapy of Middle- and High-risk Acute Myeloid Leukemia in the Elderly
- Trial name
- NCT06990321
- Testing
- Intermediate-dose Cytarabine in Combination with Venetoclax
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Yehui Tan
Acute Myeloid Leukemia, Induction Chemotherapy
Study of DAC Combined With HAAG Regimen in Newly Diagnosed AML Patients Older Than 60
The purpose of this study is to evaluate the safety and efficacy of DAC combined with HAAG regimen in the induction treatment of newly diagnosed AML patients older than 60 years.
- Trial name
- NCT04083911
- Testing
- Decitabine, Homoharringtonine, Aclarubicin, Cytarabine and G-CSF
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Plasma Cell Myeloma
Evaluation of Comprehensive Geriatric Assessment and Laboratory Biomarkers in Elderly Patients With Multiple Myeloma
This study evaluates the association between a comprehensive geriatric assessment and laboratory biomarkers with the side effects of chemotherapy in older patients with multiple myeloma (MM).
- Trial name
- NCT05918185
- Testing
- Biospecimen Collection, Comprehensive Geriatric Assessment, Electronic Health Record Review
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Mayo Clinic