Clinical trials: Geriatric Patients, open to volunteers
Lung Cancer (NSCLC), Elderly (People Aged 65 or More)
Oral Metronomic Vinorelbine and PD-1 Inhibitors in Elderly Non-small Cell Lung Cancer
The goal of this observational study is to evaluate the efficacy and safety of oral metronomic vinorelbine and PD-1 inhibitors in elderly patients with unoperable, locally advanced or metastatic non-small-cell lung cancer.
- Trial name
- NCT07041320
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Chest Hospital
Mild Cognitive Impairment, Dementia Prevention
Effectiveness of Non-pharmacological Interventions for Dementia Prevention in Elderly Patients With Mild Cognitive Impairment
The aims of this study is to evaluate the effectiveness of non-pharmacological interventions program in preventing progression from mild cognitive impairment to dementia in patients with mild cognitive impairment in the short…
- Trial name
- NCT06453746
- Testing
- Home-based cognitive training exercises, Supervised cognitive training exercises
- Where
- Vietnam
- Volunteers
- 192 people
- Sponsor
- Gia Dinh People Hospital
Children Aged 6 Years and Above With Moderate - to - Severe Active Crohn's Disease
A Clinical Trial of Taibowei® Adalimumab Injection in the Treatment of Chinese Pediatric Patients With Moderately to Severely Active Crohn's Disease
This study is a real - world clinical research of adalimumab. The project plans to enroll 30 subjects, aiming to evaluate the incidence of serious adverse events (SAEs) within 12, 26, and 52 weeks after treatment; as well as the…
- Trial name
- NCT07564505
- Testing
- Adalimumab Solution for Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Myocardial Infarction, Cardiac Rehabilitation
Construction and Application of an Intelligent Collaborative Cardiac Rehabilitation App for Middle-aged and Young Patients With Myocardial Infarction
This study is guided by the intervention mapping theory, combined with Fogg's behavior model and digital health technologies, focusing on the key rehabilitation obstacles and behavioral characteristics of young and middle-aged MI…
- Conditions
- Myocardial Infarction, Cardiac Rehabilitation, APP
- Trial name
- NCT07289815
- Testing
- Cardiac Rehabilitation Management App, Conventional Rehabilitation Guidance
- Volunteers
- 232 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Prostate Cancer
Immediate Curative vs Conservative Treatment in Older Men With M0, High-risk Prostate Cancer
It is currently unclear if immediate curative treatment (radiotherapy or surgery) of high-risk prostate cancer without metastasis in older men (>=75 years) generates the same survival benefits as in younger patients or if the…
- Trial name
- GrandP/SPCG19 (NCT05448547)
- Testing
- Radiotherapy or surgery, initial observation, Hormone therapy
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- Sven Löffeler
Post Induction Hypotension
Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery
Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery due to small incisions, low stress response, and high patient tolerance.
- Trial name
- NCT07374458
- Testing
- Esketamine, Bilateral Lower Limb Elevation
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Sarcopenia
(De)Prescribing in Hospitalized Sarcopenic Geriatric Patients
The goal of this clinical trial is to compare the effects of a deprescribing pharmacotherapy approach to the STOPP-START approach (usual care) in geriatric patients with sarcopenia and polypharmacy.
- Trial name
- MEDEGESARC (NCT05757765)
- Testing
- deprescribing pharmacotherapy approach (DPA), STOPP-START deprescribing approach (SSA)
- Volunteers
- 160 people
- Sponsor
- Zuyderland Medisch Centrum
Mantle Cell Lymphoma
PirtobrUtinib as Frontline Therapy for Elderly Unfit/Frail Patient With MAntle Cell Lymphoma
This is a prospective, multicenter, phase II study, in elderly patients affected by Mantle cell lymphoma (MCL) defined as unfit/frail according to Simplified Geriatric Assessment (sGA) and previously untreated.
- Trial name
- FIL_PUMA (NCT07207785)
- Testing
- Pirtobrutinib
- Where
- 20 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Sarcopenia in Elderly
A Study of PLH-2301 in Subjects With Sarcopenia
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of PLH-2301 in subjects with sarcopenia.
- Trial name
- PLH-2301_P2 (NCT07390552)
- Testing
- PLH-2301
- Where
- 5 sites in South Korea
- Volunteers
- 168 people
- Sponsor
- Pluto Inc.
Post-ERCP Adverse Events, ERCP Complications
Factors for Prolonged Hospital Stays in Patients Undergoing ERCP
Endoscopic retrograde cholangiopancreatography (ERCP) is a crucial minimally invasive technique for the diagnosis and treatment of biliary and pancreatic diseases.
- Trial name
- NCT07568626
- Where
- 5 sites in China
- Volunteers
- 504 people
- Sponsor
- Air Force Military Medical University, China
Major Depressive Diorder, Early Life Trauma
Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse
The purpose of this clinical research study is to understand how effective and safe an investigational study drug called lumateperone is and whether it works to reduce the severity of depressive symptoms in adults with Major…
- Trial name
- ITI-ELA-MDD (NCT07369115)
- Testing
- Lumateperone 42 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Acute Musculoskeletal Pain
Virtual Reality and Standard Care vs. Standard Care Alone for Acute MSK Pain in Geriatric ED Patients
The proposed Virtual Reality as an Adjunct to Pain Management for Geriatric Patients in the ED (VRAP-ED) project will take place in the Emergency Medicine Department at Maimonides Medical Center.
- Trial name
- NCT06685107
- Testing
- Standard of Care Analgesia, Standard of Care Analgesia + Virtual Reality
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Antonios Likourezos
Neurodegenerative Diseases, Cognition Disorders in Old Age
Probiotics in Mild Alzheimer's Disease
The main objective is to investigate whether administration of probiotics to patients with mild Alzheimer's Disease (AD) reduces neuroinflammation, improves cognitive function and modifies neurophysiological measures, compared to…
- Trial name
- NCT06181513
- Testing
- Probiotic Blend Capsule
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- University of Nicosia
Small Cell Lung Cancer Extensive Stage, ELDERLY PEOPLE
Etoposide Plus Benmelstobart Followed by Maintenance Therapy of Benmelstobart Plus Anlotinib in First-line Treatment of Elderly Patients with Extensive Stage Small Cell Lung Cancer: a Single-arm, Prospective Trial
This is a prospective, single-arm clinical study to evaluate the efficacy and safety of etoposide in combination with bemosubezumab and sequential Benmelstobart in combination with Anlotinib as first-line treatment for elderly…
- Trial name
- NCT06825208
- Volunteers
- 29 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Elderly, Cancer Surgery
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal.
- Conditions
- Elderly, Cancer Surgery, Dexmedetomidine, Long-Term Survivors
- Trial name
- NCT06030804
- Testing
- Dexmedetomidine
- Where
- 40 sites in China
- Volunteers
- 4,532 people
- Sponsor
- Peking University First Hospital
Older People
Underprescribing in Geriatric Patients: a Prevalence Study and Analysis of Factors Contributing to Potential Prescription Omissions (Under-PRES)
This observational study will determine the prevalence of underprescription in a cohort of elderly patients, recruited at the time of an outpatient geriatric visit, or hospitalized, upon admission to a geriatric ward.
- Trial name
- Under-PRES (NCT06904638)
- Where
- 2 sites in Italy
- Volunteers
- 374 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Type 2 Diabetes Mellitus (T2DM), Hyperglycemia
Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hyperglycemia, Metabolic Syndrome, Older Adults (65 Years and Older)
- Trial name
- EFIR (NCT07574333)
- Testing
- Intermittent Hypoxic-Hyperoxic Training (3 days), Intermittent Hypoxic-Hyperoxic Training (10 days), Normoxic gas breathing
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Delirium, Hypoxia
Nocturnal Hypoxia in Geriatric Patients After Hip Fracture
Delirium is a common complication following hip fracture surgery (HFS) in older people. Postoperative hypoxia has also been associated with delirium, but not specifically in geriatric patients.
- Trial name
- HIPOX (NCT04007432)
- Testing
- pulse oxymeter
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hip Fracture, Geriatrics
Clinical Efficacy of Exoskeleton Robot-Assisted Rehabilitation on Lower Limb Functional Recovery in Elderly Patients With Hip Fracture
With the intensification of population aging, hip fracture, as a common bone disease, is seeing an increasing incidence rate among the elderly population.
- Conditions
- Hip Fracture, Geriatrics, Lower Extremity Dysfunction, Postoperative Rehabilitation
- Trial name
- NCT07323147
- Testing
- Exoskeleton, Conventional rehabilitation program
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Hai bao