Clinical trials: Gestational Trophoblastic Tumor, active
Gestational Trophoblastic Neoplasia
Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7
The goal of this clinical trial is to evaluate the efficacy and safety of toripalimab plus actinomycin-D as fist-line treatment in patients with gestational trophoblastic neoplasia with FIGO score 7.
- Trial name
- TA7 (NCT06020755)
- Testing
- Toripalimab, Actinomycin-D
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Peking Union Medical College Hospital
Peritoneal Mesothelioma, Gestational Trophoblastic Tumor
IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers
Immune checkpoint inhibitors (ICI) have revolutionized the management of advanced cancers. However, most rare cancers have been excluded from this progress due to the lack of clinical trials involving these diseases.
- Conditions
- Peritoneal Mesothelioma, Gestational Trophoblastic Tumor, Anaplastic Thyroid Carcinomas, Gastroenteropancreatic Neuroendocrine Tumor
- Trial name
- IMMUNORARE5 (NCT06790706)
- Testing
- DOMVANALIMAB + ZIMBERELIMAB, DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4
- Where
- 15 sites in France
- Volunteers
- 27 people
- Sponsor
- Hospices Civils de Lyon
Gestational Trophoblastic Neoplasia, Complete Hydatiform Mole
Uterine Artery Doppler Flow Velocimetry Parameters for Predicting the Occurrence of Persistent Gestational Trophoblastic Neoplasia After Evacuation of Complete Hydatiform Mole
This Prospective study will be conducted To copare uterine blood flow using Doppler ultrasound before and after evacuation of hydatiform mole between female patients with remissions and those with development of post-molar…
- Trial name
- NCT07333326
- Volunteers
- 175 people
- Sponsor
- Minia University
Gestational Trophoblastic Neoplasia
The Psychological Impact of GTN on Women Who Have Completed Chemotherapy Treatment
A cross-sectional retrospective study of a sample of 20 women who completed single agent or multi agent chemotherapy: between 6 weeks and 24 months post treatment involving a semi structured telephone interview.
- Trial name
- PI-GTN (NCT06169644)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Gestational Trophoblastic Neoplasia
Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia
The purpose of this study is to evaluate the efficacy and safety of camrelizumab and apatinib as combination therapy in patients with ultra high-risk (Cohort A) and high-risk chemo-refractory or relapsed (Cohort B) gestational…
- Trial name
- NCT05139095
- Testing
- Camrelizumab plus apatinib CohortA, Camrelizumab plus apatinib Cohort B
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
Gestational Trophoblastic Neoplasias (GTN)
Avelumab and Methotrexate in in Low-risk Gestational Trophoblastic Neoplasias as First Line Treatment
Gestational trophoblastic neoplasias (GTN) are characterized by the persistence of elevated hCG titers after complete uterine evacuation of a partial hydatidiform mole (PHM) or a complete hydatidiform mole.
- Trial name
- TROPHAMET (NCT04396223)
- Testing
- Avelumab Injection, Methotrexate 1 GM Injection
- Where
- 9 sites in France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Hydatidiform Moles
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles
The researchers' laboratory is studying a rare class of highly recurrent hydatidiform moles. These are usually complete hydatidiform moles (CHM), but sometimes they are partial hydatidiform moles PHM).
- Trial name
- NCT01008501
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hydatidiform Mole, Gestational Trophoblastic Neoplasia
Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule
The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A.
- Trial name
- NCT03785574
- Testing
- Follow up, chemotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Gestational Trophoblastic Neoplasias (GTN)
Clinicopathological Features , Outcomes and Prognostic Factors of High Risk Patients of Gestational Trophoblastic Neoplasia
Aim of the Study This study aims to investigate the clinical and pathological features, treatment outcomes, and prognostic factors in high-risk patients with Gestational Trophoblastic Neoplasia (GTN).
- Trial name
- NCT06900699
- Volunteers
- 42 people
- Sponsor
- Assiut University
Hydatidiform Mole
A Multi-center Cohort Study of Hydatidiform Mole in China (CN-HM-01)
This observational study aims to establish a national cohort of patients with hydatidiform mole (molar pregnancy) to investigate its malignant transformation rate and malignant transformation mechanisms, with the goal of…
- Trial name
- CN-HM-01 (NCT07202728)
- Testing
- No intervention
- Where
- 14 sites in China
- Volunteers
- 1,489 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Neoplasm, Trophoblastic, Gestational Trophoblastic Disease
The French National Reference Centre of GTD
The French Gestational Trophoblastic Disease (GTD) centre has been set up and active by registering, monitoring and treating women with GTD since november 1999.
- Conditions
- Neoplasm, Trophoblastic, Gestational Trophoblastic Disease, Hydatidiform Mole, Hydatidiform Mole, Invasive
- Trial name
- French GTDC (NCT02892877)
- Where
- France
- Volunteers
- 25,500 people
- Sponsor
- Hospices Civils de Lyon
Gestational Trophoblastic Neoplasia
Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic Neoplasia
Study of hysteroscopic repeat curettage as the first-line treatment in low-risk postmolar gestational trophoblastic neoplasia compared with the MTX single drug chemotherapy
- Trial name
- NCT03703271
- Testing
- Methotrexate, hysteroscopic repeat curettage
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Gestational Trophoblastic Tumor, Gestational Trophoblastic Neoplasia
Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia
The investigators conducted a randomized trial to study how well multi-day methotrexate protocol works compared to biweekly single-dose actinomycin D protocol in treating patients with low-risk gestational trophoblastic…
- Conditions
- Gestational Trophoblastic Tumor, Gestational Trophoblastic Neoplasia, Stage I Gestational Trophoblastic Tumor, Stage II Gestational Trophoblastic Tumor
- Trial name
- NCT04562558
- Testing
- Methotrexate, Leucovorin, Dactinomycin
- Where
- China
- Volunteers
- 228 people
- Sponsor
- xiang yang
Acinar Cell Carcinoma, Adenoid Cystic Carcinoma
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may…
- Conditions
- Acinar Cell Carcinoma, Adenoid Cystic Carcinoma, Adrenal Cortical Carcinoma, Adrenal Gland Pheochromocytoma
- Trial name
- NCT02834013
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography Test
- Where
- 1,007 sites in United States, Guam
- Volunteers
- 798 people
- Sponsor
- National Cancer Institute (NCI)
Gestational Trophoblastic Neoplasia
Clinical Specialty Queue For Gestational Trophoblastic Neoplasia
The aim of this study is to establish a bidirectional cohort study of GTN specific diseases, including 1020 retrospective cases Queue and 1000 prospective cohorts.
- Trial name
- NCT06681259
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Gestational Trophoblastic Neoplasia
Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6
Whether toripalimab plus actinomycin-D as fist-line treatment can achieve a higher complete response rate than actinomycin-D alone.
- Trial name
- TA56 (NCT06028672)
- Testing
- Toripalimab, Actinomycin-D
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Hydatidiform Mole
A Cohort Study of Hydatidiform Mole
The purpose of this study is to construct a cohort for the hydatidiform mole.
- Trial name
- NCT05637892
- Testing
- No intervention
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University