Clinical trials: Gingiva Disorder
Gingivitis, Plaque
The Effects of Oscillating-Rotating Electric Toothbrushes on Plaque and Gingival Health
The aim of this analysis was to compare the effects of oscillating-rotating (O-R), side-to-side (sonic), and manual toothbrushes on plaque and gingival health after multiple uses.
- Trial name
- NCT04017507
- Testing
- Oscillating-rotating electric toothbrush, Side-to-side electric toothbrush, Manual toothbrush
- Where
- United States
- Volunteers
- 2,145 people
- Sponsor
- Procter and Gamble
Microbial Colonization
Colonisation Efficacy of a Probiotic Chewing Gum.
To evaluate the colonization efficacy (the ability of a probiotic bacteria to remain in the mouth) delivered in a chewing gum format.
- Trial name
- NCT05624177
- Testing
- Streptococcus salivarius M18 probiotic 1 billion colony forming units chewing gum (chew 5 minutes), Streptococcus salivarius M18 probiotic 1 billion colony forming units chewing gum (chew 10 minutes)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Gingivitis, Plaque
Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis
The objective of this clinical research study is to collect and analyze plaque and oral health measures in a population with high plaque/low gingivitis and high plaque/high gingivitis
- Trial name
- NCT07614490
- Testing
- sodium monofluorophosphate toothpaste
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Pancreatic Cancer
A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer
The purpose of this study is to determine whether the combination of MM-141 plus nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone based on Progression Free Survival (PFS) in front-line…
- Trial name
- CARRIE (NCT02399137)
- Testing
- MM-141, Gemcitabine, Nab-Paclitaxel
- Where
- 66 sites in United States, Canada and 4 more
- Volunteers
- 88 people
- Sponsor
- Merrimack Pharmaceuticals
Gingival Bleeding, Plaque Induced Gingival Disease
Comparative Study to Evaluate the Efficacy of an Alcohol-free Mouthwash Regimen With CPC+Zn, Flossing and Brushing, and an Alcohol-based Mouthwash Regimen With Essential Oils in Reducing Plaque and Gingivitis.
This is a Phase III, randomized, one-center, parallel group, double blinded, clinical study to evaluate the efficacy of an alcohol-free mouthwash containing CPC+Zn as compared to dental flossing and to rising with an essential…
- Conditions
- Gingival Bleeding, Plaque Induced Gingival Disease, Gingival Diseases, Gingivitis and Periodontal Diseases
- Trial name
- PGMWII (NCT06598072)
- Testing
- Mouthwash CPC+Zn+F, Essential oils mouthwash, Dental floss
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Colgate Palmolive
Gingivitis
Evaluation of the Effect of the Toothpaste on Delicate Gums
The goal of this study is to learn if a toothpaste works to alleviate gingivitis in adults. It will also learn about the safety of the product.
- Trial name
- NCT07494747
- Testing
- Gingivitis toothpaste, Regular toothpaste
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Lacer S.A.
Gingivitis
A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks
The aim of this study is to investigate the impact of a stannous fluoride containing toothpaste in reducing gingivitis when used twice daily for a maximum for 3 weeks, when compared to a standard sodium fluoride toothpaste…
- Trial name
- NCT04050722
- Testing
- Sensodyne Repair and Protect, Colgate Cavity Protection
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mouth, Edentulous
Study to Evaluate Bone and Gum Dimension Changes Around Dental Implants Placed in Different Positions in Bone.
The purpose of this study is to test two standard of care techniques of placing dental implants, and to compare how people's bones and gums respond to two different depths at which implants are placed.
- Trial name
- NCT01759537
- Testing
- Ankylos dental endosseous implants-Sub-crestal, Ankylos dental endosseous implants-Epi-crestal
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dentsply International
Gingivitis, Dental Plaque Accumulation
6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health
The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health.
- Trial name
- NCT07414173
- Testing
- Test Mouthrinse, Control Mouthrinse
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Dental Plaque
A Clinical Comparison of an Experimental Power Brush Compared to a Manual Toothbrush
The objective of the study is to evaluate and compare the efficacy of an experimental power brush to a regular manual brush in the reduction of gingivitis and dental plaque over an 8 week period by using the Modified Gingival…
- Trial name
- NCT03624647
- Testing
- Power toothbrush, Manual toothbrush
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingival Diseases
Pilot Efficacy Study to Treat Gingivitis
The primary purpose is to demonstrate the efficacy of a prescription mouthrinse in human subjects for treatment of Gingivitis.
- Trial name
- NCT00391547
- Testing
- Frio Oral Rinse
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Biomedical Development Corporation
Gingivitis, Plaque
Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.
Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided.
- Trial name
- NCT06244303
- Testing
- manual Tooth Brush + Colgate Total TP (0.454% SnF, 1100 ppm F), manual toothbrush + Colgate dental cream
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Recession
A Pilot Clinical Trial of Gintuit (TM)in Establishing a Functional Zone of Attached Gingiva
The purpose of this study is to evaluate the safety and efficacy of Gintuit compared to a free autogenous graft using donor tissue harvested from the subject's palate in the treatment of subjects who have an insufficient zone of…
- Trial name
- NCT01547962
- Testing
- Gintuit, autologous Free Gingival Graft (FGG)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Organogenesis
Gingivitis, Dental Plaque
A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal
The main goal of this study is to evaluate and compare the efficacy of an on-market dentifrice containing 67 percent (%) sodium bicarbonate and 0.31% sodium fluoride to a reference regular fluoride dentifrice on treating gingival…
- Trial name
- NCT05654662
- Testing
- Corsodyl Original Dentifrice, Colgate Cavity Protection Dentifrice
- Where
- United Kingdom
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis
Effects of Antioxidant Dentifrice on Gingivitis
The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.
- Trial name
- NCT02102295
- Testing
- Experimental toothpaste, Control toothpaste
- Where
- 4 sites in Japan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Lion Corporation
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque and Gingivitis
The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
This is a six (6) month, double-blind, parallel, controlled clinical trial utilizing one hundred and sixty (160) adults to evaluate the reduction of dental plaque and gingivitis.
- Trial name
- NCT02243046
- Testing
- Control toothpaste, Experimental toothpaste, Active Comparator
- Where
- Dominican Republic
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Evaluation of the Addition of an Interdental Cleaning Device to Manual Brushing on Gingival Health
This study evaluates the addition of an interdental cleaning device paired with a manual toothbrush compared to using a manual toothbrush only. Plaque removal, reduction of gingival bleeding and reduction of gingival inflammation.
- Trial name
- NCT02836223
- Testing
- Interdental cleaning device, Manual Tooth brush
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Water Pik, Inc.
Dental Plaque
Investigation of Dental Plaque and Gingival Index
Investigation of inhibitory effect of prototype toothpaste on dental plaque formation via modified gingival margin plaque index method.
- Trial name
- NCT00759031
- Testing
- Sodium Monofluorophosphate, Triclosan/Fluoride/Copolymer
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
A Study to Evaluate the Effect of a Test (Sodium Bicarbonate) Toothpaste on the Oral Microbiome
The aim of this 12-week clinical study is to evaluate the effect of a toothpaste containing sodium bicarbonate over time on the oral microbiome and to explore its effect in comparison to a regular fluoride toothpaste in…
- Trial name
- NCT07273539
- Testing
- Sodium Bicarbonate Toothpaste, Sodium Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- HALEON