Clinical trials: Gingival Crevicular Fluid
Gingival and Periodontal Disease, Space Maintenance
The Effects of Fixed Space Maintainers Luting with Self-Adhesive Resin Cement on the Gingival Crevicular Fluid of Interleukin-18 Level
Background:In pediatric dentistry, fixed space maintainers are crucial for preserving the space in edentulous areas following premature tooth loss and promoting the healthy development of the dental arch, maxilla, and mandibula.
- Conditions
- Gingival and Periodontal Disease, Space Maintenance, Resin Cements, Interleukin
- Trial name
- NCT06811597
- Testing
- Voco Meron Conventional Glass Ionomer, High-Q-Bond Band™ self-adhesive resin cement.
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Afyonkarahisar Health Sciences University
Stage II Grade B Periodontitis
Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B Periodontitis
This randomized controlled clinical trial will evaluate the effectiveness of locally delivered active oxygen gel and chlorhexidine gel as adjuncts to scaling and root planing in the treatment of stage II grade B…
- Trial name
- NCT07840716
- Testing
- Active oxygen gel, Chlorhexidine gel
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Periodontitis and Rheumatoid Arthritis
ESTIMATION OF GINGIVAL CREVICULAR LEVEL OF YKL40
The presence of YKL- 40 an acute phase protein in both chronic periodontitis and rheumatoid arthritis. However, till date no studies has been done on the levels of gingival crevicular fluid YKL-40 following scaling and root…
- Trial name
- NCT03995615
- Testing
- scaling and root planing
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Gingivitis
Evaluation of Gingival Crevicular Fluid Cytokine Profiles in Children and Young Adults With Gingivitis
This prospective observational case-control study aims to compare gingival crevicular fluid (GCF) biomarker profiles between children and young adults diagnosed with gingivitis.
- Trial name
- NCT07607639
- Testing
- Gingival Crevicular Fluid Biomarker Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Chronic Periodontitis
Osteoprotegerin Before and After Periodontal Surgery
The study hypothesis: Is Osteoprotegerin a diagnostic and/or prognostic marker of periodontal disease?
- Trial name
- NCT02160613
- Testing
- Open flap debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls
Periodontitis is an inflammatory disease characterized by periodontal tissue destruction caused by bacterial infection. The immune response plays an important role in the progression of periodontitis.
- Trial name
- NCT05306860
- Testing
- No intervention was applied to the groups the samples will be collected in terms of the diagnosis (periodontitis, healthy)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Periodontitis, Gingival Crevicular Fluid
Gingival Crevicular Fluid (GCF) Bactericidal Permeability Protein (BPI) and Interleukin (IL)-1 Beta
Objective: The aim of this study is to determine the amounts of BPI (Bactericidal permeability protein) and interleukin-1beta (IL-1β) in gingival fluid samples obtained from individuals with periodontally healthy and periodontal…
- Conditions
- Periodontitis, Gingival Crevicular Fluid, Interleukin 1-beta, Bactericidal Permeability Protein
- Trial name
- NCT06295666
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontal Diseases
GCF Levels of Chemokines in Periodontitis
This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes.
- Trial name
- NCT06291454
- Testing
- Routine periodontal examination
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ordu University
Chronic Periodontitis, Diabetes Mellitus
Gingival Crevicular Fluid Vaspin and Omentin Levels in Type 2 Diabetic Patients With Chronic Periodontitis
The aim of the present study were 1) to determine the role of these adipokines in the pathogenesis of periodontal disease, inflammation and tissue destruction comparing with gingival crevicular fluid (GCF) levels of TNF-α, which…
- Trial name
- NCT02544347
- Testing
- gingival crevicular fluid, non-surgical periodontal treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontal Diseases, Obesity
Evaluation of Periodontal Diseases and Obesity in Women
The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin…
- Trial name
- NCT03442920
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Periodontitis
Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels
The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic…
- Trial name
- NCT04053660
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ordu University
Periodontitis
Evaluation of Prognostic Potentials of Gingival Crevicular Fluid E-cadherin and Total Antioxidant Capacity
Ability to anticipate the outcomes of periodontal therapy at baseline visit is crucial to outline and customize a treatment plan with predictable outcomes and cost-effectiveness.
- Trial name
- NCT05994885
- Testing
- Root surface debridement
- Where
- Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ali A Abdulkareem
Smoking, Periodontitis
The Effect of Smoking and Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Cyclophilin A and EMMPRIN Levels
This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis.
- Conditions
- Smoking, Periodontitis, Non-surgical Periodontal Treatment
- Trial name
- NCT04430764
- Testing
- non-surgical periodontal treatment
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ege University
Orthodontic Tooth Movement, Gingival Crevicular Fluid
Intermittent Vibrational Force During Orthodontic Treatment With Aligners
This three-arm cross-over randomized clinical trial (allocation ratio of 1:1:1) will aim to explore whether the application of intermittent vibratory forces modify RANKL and OPG concentrations in patients undergoing orthodontic…
- Conditions
- Orthodontic Tooth Movement, Gingival Crevicular Fluid, Biomarkers
- Trial name
- NCT05316636
- Testing
- Vibrational forces, Orthodontic treatment with clear aligners
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Universidad Complutense de Madrid
Acute Coronary Syndrome, Periodontitis
Neutrophil Elastase, Elastase Alpha-1 Proteinase, Periodontitis, Gingival Crevicular Fluid and Acute Coronary Syndrome
Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS).
- Trial name
- NCT04785235
- Testing
- Non-Surgical Periodontal Therapy
- Volunteers
- 43 people
- Sponsor
- Baskent University
Chronic Periodontitis, Diabetes Mellitus
Chemerin and IL-6 Levels in Diabetes and Periodontitis
The aims of the present study were to determine the gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) levels and to analyse the relationship between chemerin and IL-6 in periodontal health and in chronic…
- Trial name
- NCT02596581
- Testing
- non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontitis (Stage 3)
Effects of Non-Surgical Periodontal Treatment on Inflammatory and Bone Markers in Periodontitis Patients
The goal of this study is to learn how a standard treatment called Scaling and Root Planing (SRP) affects specific biochemical markers in people with advanced gum disease (periodontitis).
- Trial name
- GPNMB-PERIO St (NCT07475013)
- Testing
- Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Type 2 Diabetes Mellitus
Prolactin Levels in Type 2 Diabetic Patients With Stage III Periodontitis
evaluate the role of prolactin hormone in the pathogenesis of periodontitis by assessing its local gingival levels and assess clinical parameters in patients who have type two diabetes
- Trial name
- prolactin (NCT06941246)
- Testing
- Non Surgical Periodontal Treatment, paper points, ELISA Kits
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Periodontitis, Periodontal Health
Asprosin Level in Individuals With Periodontal Disease
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis…
- Conditions
- Periodontitis, Periodontal Health, Gingivitis
- Trial name
- ALIGCF (NCT06627972)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Smoking, Healthy Volenteers
Evaluation of GCF MMP-1, -8 and Growth Factor Levels in Smokers With Periodontal Health
Increased levels of cytokines in GCF have been demonstrated in smoker subjects with chronic periodontitis. It is not surprising that increased levels of inflammation associated molecules in GCF has been observed in smokers with…
- Trial name
- NCT02014857
- Testing
- Gingival Crevicular Fluid Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ege University