Clinical trials: Gingival Neoplasms
Head and Neck Neoplasms, Radiodermatitis
Topical Boswellia Serrata 2% to Prevent Radiation Dermatitis in Head and Neck Cancer
This study evaluates a topical 2% Boswellia serrata (Indian olibanum) gum-resin cream for the prevention of acute radiation-induced dermatitis in patients with head and neck cancer undergoing radiotherapy.
- Trial name
- NCT07778290
- Testing
- Boswellia serrata 2% topical cream
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Youssef Hashem Hafez
Periodontitis
GCF PLAP-1, Sclerostin and TNF-α Levels in Periodontitis
Periodontal ligament-associated protein-1 (PLAP-1) and sclerostin play an important role in the suppression of bone formation. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine involved in periodontal…
- Trial name
- NCT05656989
- Testing
- Periodontal clinical measurements and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Palatal Neoplasms, Lip Neoplasm
Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
Objectives Validate the OncAlert® RAPID Test by demonstrating that NPV > (1 -prevalence). Evaluate the independent and associated contribution of readily available clinical variables including age, race, gender, HPV status…
- Conditions
- Palatal Neoplasms, Lip Neoplasm, Gingival Neoplasms, Leukoplakia, Oral
- Trial name
- NCT03239834
- Testing
- OncAlert
- Where
- 26 sites in United States
- Volunteers
- 893 people
- Sponsor
- Vigilant Biosciences, Inc.
Oral Leukoplakia, Oral Leukoplakia of Tongue
Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore
Oral squamous cell carcinomas (OSCC) is among the most common malignancies worldwide. Early detection and prevention of OSCC is thought to have the highest potential to reduce morbidity and mortality.
- Conditions
- Oral Leukoplakia, Oral Leukoplakia of Tongue, Oral Leukoplakia of Gingiva, Oral Lichen Planus
- Trial name
- PREDICT-OLP (NCT03975322)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Colon Cancer Screening
Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy
Colorectal cancer is the second leading cause of cancer deaths that could be prevented in the United States. Colonoscopy is the best test for finding and removing polyps before they turn into cancer.
- Trial name
- NCT07320989
- Testing
- Chewing Sugar-Free Gum During Bowel Preparation, Standard Bowel Prep (2L PEG-ELP), Standard Bowel Prep
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Chemotherapy-induced Oral Mucositis
Using Gum Arabic for Cancer Patients to Protect From Oral Mucositis Caused by Chemotherapy: ِِِAn Experimental Study
This study was designed to investigate the effect of Gum Arabic (GA) on cancer patients to prevent chemotherapy-induced oral mucositis.
- Trial name
- NCT03348241
- Testing
- Gum Arabic, Chemotherapy, Lifestyle counseling
- Volunteers
- 386 people
- Sponsor
- University of Science and Technology, Yemen
Polycystic Ovary Syndrome
Effects of Gum Arabic Ingestion on Hormonal and Metabolic Changes in Patients With Polycystic Ovary Syndrome
To assess the effects on hormonal and metabolic changes in the PCOs patients after ingestion of Arabic gum
- Trial name
- GA&PCO (NCT04215380)
- Testing
- Acacia Senegal extract, Pectin
- Where
- Sudan
- Volunteers
- 60 people
- Sponsor
- Lamis Kaddam
Mammary Neoplasm, Human, Periodontal Diseases
Cytokine Profiles in Breast Cancer Patients Undergoing Chemotherapy
Aim: This study evaluated the effects of non-surgical periodontal therapy (NSPT) on the cytokine profile and the correlation to clinical parameters of patients undergoing chemotherapy for breast cancer.
- Conditions
- Mammary Neoplasm, Human, Periodontal Diseases, Chemotherapy Effect
- Trial name
- NCT03244943
- Testing
- Non surgical periodontal Treatment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Oral Epithelial Dysplasia, Precancerous Conditions
Oral Epithelial Dysplasia Informational Needs Questionnaire
Background: Oral epithelial dysplasia (OED) is a condition with an increased risk of oral cancer. Due to the current changes in the factors associated with these diseases (because of human papillomavirus), it is expected that…
- Conditions
- Oral Epithelial Dysplasia, Precancerous Conditions, Precancerous Lesions, Oral Lichen Planus
- Trial name
- ODIN-Q (NCT04153266)
- Testing
- No intervention is planned for this study
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Polycystic Ovary Syndrome, Inflammation Gum
Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation
Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense.
- Conditions
- Polycystic Ovary Syndrome, Inflammation Gum, Cytokines
- Trial name
- NCT03264846
- Testing
- Collection of Serum and Saliva Samples
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ebru Saglam
Upper Gingival Squamous Cell Carcinoma
Role of FCγRIIIA and FCγRIIA Receptor Polymorphisms
Hypothesis: Cetuximab, an anti-EGFR antibody, is used with radiotherapy in the treatment of locally advanced and inoperable upper aerodigestive tract cancers.
- Trial name
- FCR-VADS (NCT01827956)
- Testing
- Cetuximab
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Institut Bergonié
Periodontitis, Adult, Periodontal Pocket
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant.
- Conditions
- Periodontitis, Adult, Periodontal Pocket, Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT03453476
- Testing
- SRP and Fotosan 630
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
This study is an open-label, international, multi-center, Phase 2 study in adult patients with recurrent, locally-advanced or metastatic solid tumors, which harbor the NRG1 gene fusion.
- Conditions
- Locally Advanced Solid Tumor, Metastatic Solid Tumor, Pancreatic Cancer, Lung Cancer
- Trial name
- NCT04383210
- Testing
- Seribantumab
- Where
- 42 sites in United States, Australia and 2 more
- Volunteers
- 54 people
- Sponsor
- Elevation Oncology
Periodontitis, Periodontal Health
Asprosin Level in Individuals With Periodontal Disease
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis…
- Conditions
- Periodontitis, Periodontal Health, Gingivitis
- Trial name
- ALIGCF (NCT06627972)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)
The study is an open-label phase I/II clinical trial. The study will enroll patients to receive neoadjuvant SBRT plus 1 or 2 doses of neoadjuvant pembrolizumab with concurrent ficerafusp alfa (4 doses) prior to definitive…
- Trial name
- NCT07552558
- Testing
- Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Washington University School of Medicine
Paralytic Ileus
Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer
Following extensive abdominal surgery for the treatment of endometrial or ovarian cancer, paralytic ileus frequently develops. Gum chewing can promotes the return of bowel function through the cephalic-vagal reflex and increased…
- Trial name
- NCT01389986
- Testing
- Gum chewing
- Where
- Thailand
- Sponsor
- Chiang Mai University