Clinical trials: Gingivitis
Plaque, Gingivitis
Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study
The objective of this randomized, single-center, examiner-blind, controlled, parallel group, six-month clinical study is to compare the antiplaque/antigingivitis potential of a no-alcohol essential oil containing mouthrinse and…
- Conditions
- Plaque, Gingivitis, Gum Inflammation, Bleeding
- Trial name
- NCT02980497
- Testing
- Listerine Zero Mouthwash (without alcohol), Listerine Antiseptic Mouthwash (with alcohol)
- Where
- Brazil
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Healthy
Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria Saliva and Bioaerosol Contamination Phase 2
To evaluate the antibacterial efficacy of a commercial mouthwash containing 1.5% hydrogen peroxide in reducing the levels of bacteria in bioaerosols generated by dental prophylaxis.
- Trial name
- NCT04717063
- Testing
- Peroxyl Oral Product
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Stannous Fluoride and Gingivitis
8-week study using stannous fluoride toothpaste on subjects with gingivitis ("unhealthy") and without gingivitis ("healthy"). Gingivitis index will be performed at BL, Week 4 and Week 8.
- Trial name
- NCT05326373
- Testing
- Stannous fluoride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingivitis
A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice
The objective of this clinical study is to assess the effects of a 0.454% stannous fluoride dentifrice on gingivitis and plaque after 3 months when compared to a negative control.
- Trial name
- NCT03936569
- Testing
- Marketed Toothpaste, Marketed Cavity Protection Toothpaste
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingival Inflammation, Dental Plaque
A Study to Measure the Effect of a Toothpaste Containing Proteins and Enzymes and a Fluoride Toothpaste on Gingival Health
This study is a double-blind, randomised, parallel group efficacy study. A minimum of 240 healthy female and male participants aged 18-70 years will be enrolled onto the study according to the inclusion/exclusion criteria.
- Trial name
- NCT06932211
- Testing
- Toothpaste containing proteins and enzymes, Control fluoride toothpaste
- Where
- China
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Gingivitis
Evaluate Inflammation Caused by Gingivitis in Adults
The purpose of this study is to compare the anti-inflammatory efficacy of a dentifrice
- Trial name
- NCT00941668
- Testing
- Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Gingivitis
A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health
The aim of this study will be to evaluate the ability of using an experimental dentifrice containing 0.454 percent (%) weight for weight (w/w) Stannous Fluoride (SnF2) to reduce gingivitis and plaque accumulation, compared with a…
- Trial name
- NCT07704905
- Testing
- Test Dentifrice, Reference Dentifrice (Colgate Cavity Protection Dentifrice)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis
A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
The purpose of this study is to evaluate and compare the gingival health of a test dentifrice (0.454% weight by weight [w/w] stannous fluoride) to a negative control dentifrice by comparing modified gingival index, bleeding index…
- Trial name
- NCT04123665
- Testing
- Stannous fluoride, Sodium monofluorophosphate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Plaque, Gingivitis
Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health
Since over 50% of the US population have gingivitis, mouthrinses serve as a valuable adjunct to brushing and flossing. The primary objective is to determine the effectiveness of the oral rinse in reducing plaque and gingivitis…
- Trial name
- NCT04197427
- Testing
- Experimental Oral Rinse
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- You First Services
Gingivitis, Plaque
Self-selection Study of the Toothwave Toothbrush
This study objective is to test the Silk'n Toothwave self-selection, by potential end users. Additionally, this study will evaluate if contraindicated subjects will self-exclude from use of the device and the ability to…
- Conditions
- Gingivitis, Plaque, Calculus, Tooth Discoloration
- Trial name
- NCT04023097
- Testing
- Toothwave toothbrush
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Gingivitis
Clinical Study to Assess Therapeutic Delay and Resolution of Induced Gingivitis
Evaluate a stannous technology for its effect on the neutrophil phenotype during an induced gingivitis state.
- Trial name
- NCT05731778
- Testing
- Stannous Fluoride Toothpaste, Colgate fluoride toothpaste
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Gingival Bleeding
Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual Toothbrush
This is a study to evaluate the safety and the efficacy of an electric flosser (interproximal cleaning aid), when used with a manual toothbrush, on gingivitis and dental plaque removal.
- Conditions
- Gingivitis, Gingival Bleeding, Dental Plaque
- Trial name
- NCT07779564
- Testing
- Electric Flosser, Manual Toothbrush
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Flaus, Inc
Gingivitis
A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
The aim of this study is to develop a daily use toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride with the intention of providing improved/ fast gum healing.
- Trial name
- NCT04737538
- Testing
- Experimental Dentrifrice, Positive control dentifrice, Negative control dentifrice
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingivitis
A Follow-Up Survey of Oral Hygiene and Health Outcomes for Women Previously Enrolled in "OHMOM"
The objective of this study is to assess oral health, oral hygiene knowledge, and daily oral hygiene practices of women who participated in a randomized controlled trial (2011001) at University of Alabama Birmingham during the…
- Trial name
- OHBABY (NCT02922010)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingivitis
Clinical Study Examining the Control of Plaque and Gingivitis
The objective of this six-month clinical investigation is to evaluate the efficacy of a silica-free meridol toothpaste versus Colgate Cavity Protection Toothpaste in the control of established dental plaque and gingivitis.
- Trial name
- NCT07842978
- Testing
- Silica Free Meridol, Meridol, Colgate Dental Product
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Clinical Investigation of PerioGard (Test) Regimen
The objective of this three-month clinical research study is to evaluate the clinical efficacy of the PerioGard (test) regimen (0.45% SnF-HW Toothpaste, CPC-Zinc-Fluoride Mouthwash, Gummy Toothbrush) compared to the control…
- Trial name
- NCT07210138
- Testing
- PeriGuard regimen, Colgate Dental Cream regimen
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque
Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals
The purpose of the study is to assess the effect of enzyme containing lozenges on dental plaque accumulation in healthy adults.
- Trial name
- NCT05082103
- Testing
- Enzyme lozenge 1, Enzyme lozenge 2
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Gingivitis
A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
The purpose of this study is to investigate the effectiveness of usage of a range of oral products (toothpaste, mouth rinse, denture cleanser) on the oral health of partial denture wearers compared to existing oral hygiene…
- Trial name
- NCT04290624
- Testing
- Experimental Dentifrice: Stannous Fluoride, COREGA Denture Foaming Cleanser, Mouth rinse: Sodium Fluoride
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis
Meta-analysis of Stannous Fluoride and the Effects on Gingival Health
The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on gingivitis relative to a positive or negative control dentifrice.
- Trial name
- NCT03970759
- Testing
- Stannous Fluoride Dentifrice, Positive control dentifrice, Negative control dentifrice
- Where
- United States
- Volunteers
- 2,890 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Calculus
Testing if Tartarase Can Remove Dental Tartar
This study was designed to find our whether a novel toothpaste containing safe digestive enzymes (Tartarase) was able to remove pre-existing dental tartar when compared to a well-known toothpaste (Crest).
- Trial name
- NCT06139835
- Testing
- Tartarase
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pontis Biologics, Inc.