Clinical trials: Gingivitis, completed
Periodontitis Chronic Generalized Severe, Gingivitis
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Periodontal disease is a chronic progressive state of inflammation pertaining to supporting tissues of the dentition that culminates in loss of the affected teeth.
- Conditions
- Periodontitis Chronic Generalized Severe, Gingivitis, Inflammatory Response
- Trial name
- NCT06016023
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Gingivitis, Dental Plaque
A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal
The main goal of this study is to evaluate and compare the efficacy of an on-market dentifrice containing 67 percent (%) sodium bicarbonate and 0.31% sodium fluoride to a reference regular fluoride dentifrice on treating gingival…
- Trial name
- NCT05654662
- Testing
- Corsodyl Original Dentifrice, Colgate Cavity Protection Dentifrice
- Where
- United Kingdom
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- HALEON
Periodontitis, Periodontal Diseases
Vitamin D Supplementation Prior to Non-surgical Periodontal Therapy
The purpose of this study is to test the feasibility i. e. to examine all aspects necessary for the implementation of a future randomized clinical trial (RCT) that aims to determine whether non-surgical periodontal treatment can…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Inflammation
- Trial name
- NCT05398770
- Testing
- Vitamin D supplementation (30 µg/d)
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- University of Tromso
Dental Plaque, Dental Plaque Induced Gingivitis
Clinical Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC)
This is an experimental gingivitis clinical study to evaluate gum health efficacy from the combination effect of water flosser and chemistry (0.075% CPC) compared to water flosser and water and to no oral hygiene regimen with a…
- Conditions
- Dental Plaque, Dental Plaque Induced Gingivitis, Dental Plaque and Gingivitis, Gingivitis
- Trial name
- WFPOC (NCT06607172)
- Testing
- oral irrigator, Cetylpyridinium Chloride (CPC)
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Functional Chewing Gum in Reduction of Gingival Inflammation
The aim of this prospective randomized 3-month double-blinded single center study is to determine whether a chewing gum device with food additive chitosan, will aid in reducing gingival inflammation by supplementing traditional…
- Trial name
- NCT03237624
- Testing
- Functional Chitosan Chewing Gum, Control Chewing Gum, Oral hygiene measures
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Maryland, Baltimore
Gingivitis
Propolis Containing Chewing Gum and Gingivitis
Propolis is a natural, non-toxic, sticky substance produced by honeybees that can kill bacteria, fungi, and larvae invading the beehive. It has been used in the treatment of infections and healing of wounds and burns for years.
- Trial name
- NCT06685419
- Testing
- Propolis containing gum
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- naksaka
Gingivitis, Ultra-processed Food
Impact of Ultra-Processed Food Intake on Gingival Tissue Health
The shift towards consuming more industrialized food products, particularly ultra-processed foods, has been linked to a rise in non-communicable diseases globally.
- Conditions
- Gingivitis, Ultra-processed Food, Prevention
- Trial name
- NCT06411535
- Testing
- Full-mouth ultrasonic debridement plus Nutritional counseling, Full-mouth ultrasonic debridement
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University of Siena
Plaque, Dental, Gingivitis
Evaluation of Toothbrush Bristles in Plaque Reduction
The purpose of this cross-over clinical research is to evaluate the cleaning efficacy of toothbrushes tufted with two types of tapered bristles and end rounded bristles in removal of interdental plaque with clinical measurement…
- Trial name
- NCT04681885
- Testing
- Tapered bristles A, Tapered bristles B, End rounded bristles
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sunstar Americas
Periodontitis, Periodontal Health
Asprosin Level in Individuals With Periodontal Disease
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis…
- Conditions
- Periodontitis, Periodontal Health, Gingivitis
- Trial name
- ALIGCF (NCT06627972)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Dental Plaque
Livionex Oral Microbiome and Dental Plaque Control in HSCT Recipients
Children undergoing chemotherapy, radiation treatment and Hematopoietic Stem Cell Transplantation (HSCT) have significant difficulties achieving good oral hygiene and dental plaque control.
- Trial name
- NCT02617407
- Testing
- Livionex® Dental Gel, PreviDent 5000 plus/Tom's of Maine Children's toothpaste, Kolibree Toothbrush
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Dental Plaque
Comparison of the Clinical and Microbiological Effects of CHX and HOCl Containing Mouthwashes
The primary objective of the study is to compare the antiplaque and anti-inflammatory effects of HOCl mouth rinse with those of CHX mouth rinse.
- Trial name
- NCT06589193
- Testing
- HOCl, CHX
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Baskent University
Gingivitis
Dietary Diversities: Exploring the Influence of Keto Diet and Intermittent Fasting on Oral Health and Salivary Inflammatory Biomarkers
This study aims to investigate the impact of short term, two distinct dietary interventions, namely the Keto diet and Intermittent Fasting on oral health by measuring the severity of: Periodontal diseases (Gingivitis).
- Trial name
- NCT06597708
- Testing
- keto diet, intermittent fasting with calorie restriction
- Where
- Iraq
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Polycystic Ovary Syndrome, Gingivitis
Evaluation of the Effect of Non-Surgical Periodontal Treatment in Women With Polycystic Ovary Syndrome
The goal of this clinical trial is to compare women with polycystic ovary syndrome and systemically healthy woman in relation to their gums and gum treatment outcomes as well as to investigate the role of a new biomarker in gum…
- Trial name
- NCT06567132
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Gingivitis, Plaque
Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.
The objective of this six-month clinical research study is to evaluate the clinical efficacy of two dentifrices - Toothpaste containing zinc lactate and Colgate Cavity Protection Toothpaste in reducing gingivitis and dental…
- Trial name
- NCT06563518
- Testing
- Meridol, Colgate Cavity Protection
- Where
- Thailand
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Plaque
Effect of Probiotic Toothpaste and Regular Toothpaste on Plaque Levels of Orthodontic Patients
This study is set to determine the improvement in plaque levels utilizing Plaque Index Simplified scores in orthodontic patients using probiotic toothpaste and regular toothpaste.
- Trial name
- NCT06473792
- Testing
- Probiotic Toothpaste
- Where
- Pakistan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Kanza Tahir
Periodontitis, Gingivitis
Herbal Pralines - Oral Health
This randomized, double-blinded, placebo-controlled two-arm, parallel group clinical trial is designed to evaluate the impact of the consumption of two herbal pralines containing 200 mg nitrate on clinical signs of gingival…
- Trial name
- NCT06090851
- Testing
- herbal nitrate Pralines with nitrate, herbal nitrate Pralines without nitrate
- Where
- 2 sites in Germany
- Volunteers
- 44 people
- Sponsor
- Wuerzburg University Hospital
Peri-Implantitis, Peri-implant Mucositis
Peri-implant Conditions Mimic Periodontal Conditions
Except for patients with referred clinical bruxism and uncontrolled medical conditions, the study included 123 implants with implanted fixed prostheses that had lasted at least six months after functional prosthetic loading.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Peri-implant Health, Periodontitis
- Trial name
- NCT06128850
- Testing
- disease
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Gingivitis, Orthodontics
Effectiveness of Different Types of Toothbrushes on Periodontal Health in Orthodontic Patients
The goal of this clinical trial is to compare the effectiveness of different toothbrushes in patients with fixed orthodontic appliances who have gingival inflammation. The main questions it aims to answer are: 1.
- Trial name
- NCT06510179
- Testing
- Toothbrushing
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Okan University
Dental Implantation, Peri-implant Mucositis
Evaluation of Peri-implant Conditions of Orthodontic Mini Implants
This observational study aims to evaluate the peri-implant conditions of mini implants placed during orthodontic treatment. Orthodontic mini implants are commonly used as temporary anchorage devices to prevent or reduce unwanted…
- Conditions
- Dental Implantation, Peri-implant Mucositis, Gingival Inflammation, Implant Stability
- Trial name
- NCT06491849
- Testing
- Peri-implant Condition Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. Mehmet Selim Yildiz
Oral Dysbiosis
Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis
Dysbiosis is a condition in which the normal function of an ecological net is altered. In dysbiosis a state of inflammation, a loss of hydration, a change in pH, a loss of the barrier function are all allies of key pathogens that…
- Trial name
- NCT05463484
- Testing
- Test composition Saliactive® (olive product, betaine and xylitol), Control
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Mucosa Innovations, S.L.