Clinical trials: Girls
Ovarian Carcinoma
REGorafenib vsTamoxifen in Patients With Platinum-sensitive OVARian Carcinoma and Isolated Biological Progression
The objective of this randomized phase II is to evaluate the benefit of regorafenib for ovarian patients who reported a confirmed elevated CA-125 level under surveillance or bevacizumab, compared with tamoxifen.
- Trial name
- REGOVAR (NCT02584465)
- Testing
- Tamoxifen, Regorafenib
- Where
- 21 sites in France
- Volunteers
- 68 people
- Sponsor
- ARCAGY/ GINECO GROUP
Exocrine Pancreas Carcinoma, Malignant Solid Neoplasm
Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial
This phase II ComboMATCH treatment trial evaluates the effectiveness of palbociclib and binimetinib in treating patients with RAS-mutated cancers.
- Conditions
- Exocrine Pancreas Carcinoma, Malignant Solid Neoplasm, Ovarian Low Grade Serous Adenocarcinoma, Stage IV Ovarian Cancer AJCC v8
- Trial name
- NCT05554367
- Testing
- Binimetinib, Biopsy Procedure, Biospecimen Collection
- Where
- 265 sites in United States, Puerto Rico
- Volunteers
- 199 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Kidney Disease(CKD), Multimorbidity
Acceptability and Feasibility of Interventions for Integrated Care of Chronic Kidney Disease With Other Long-term Health Conditions in Malawi: a Qualitative Study
The burden of chronic kidney disease (CKD) is rising globally, but disproportionately impacting on low- and middle-income countries (LMIC) including Malawi, which have the fewest resources to manage it.
- Conditions
- Chronic Kidney Disease(CKD), Multimorbidity, Long-term Health Conditions
- Trial name
- Impso (NCT06807567)
- Testing
- Receipt of healthcare for long-term conditions, Provision of healthcare, Policy making
- Where
- Malawi
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Infertility, Infertility, Female
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells
To develop a deeper understanding of endometrial-embryo crosstalk through basic research, uncover therapeutic targets and to improve reproductive outcome.
- Conditions
- Infertility, Infertility, Female, Aneuploidy
- Trial name
- Ca2+ (NCT04865367)
- Testing
- Exposure to culture media
- Where
- United Arab Emirates
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Interstitial Cystitis, Bladder Pain Syndrome
A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
The aim of this study is to assess whether IW-3300 is safe and works for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS).
- Trial name
- NCT05740007
- Testing
- IW-3300 rectal foam
- Where
- 53 sites in United States
- Volunteers
- 98 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Ovarian Cancer
ISIS 5132 in Treating Patients With Metastatic or Recurrent Ovarian Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of ISIS 5132 in treating patients who have metastatic or…
- Trial name
- NCT00003892
- Testing
- ISIS 5132
- Where
- 66 sites in United States, Canada and 1 more
- Volunteers
- 22 people
- Sponsor
- NCIC Clinical Trials Group
Acute Coronary Syndrome, Atrial Fibrillation
Short- and Long-term Health Effects of Air Pollution in Poland
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack…
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury
- Trial name
- EP-PARTICLES (NCT05198492)
- Testing
- Impact of air pollution
- Where
- Poland
- Volunteers
- 8,300,000 people
- Sponsor
- Medical University of Bialystok
Communication Skills, Patient Satisfaction
Empathy Training and Its Effect on Maternity Nurses' Communication Skills
The goal of this clinical trial is to evaluate the effectiveness of empathy skills training on Maternity Nurses' Communication and Parturient Women's Perception of Empathetic Care.
- Trial name
- NCT07248592
- Testing
- Maternity Nurse Empathy and Communication Skills Training Program
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Nephrolithiasis
Ultrasound First Clinical Decision Support for Suspected Nephrolithiasis
This is a randomized trial to determine the effectiveness of a clinical decision support tool on image ordering for patients with suspected nephrolithiasis.
- Trial name
- NCT03461536
- Testing
- Ultrasound-first Clinical Decision Support tool
- Where
- United States
- Volunteers
- 388 people
- Sponsor
- University of California, San Francisco
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Renal Stones
Management of Medium Sized Renal Stones
Urinary stone disease is a common urological condition that affects millions of people worldwide, often leading to significant morbidity and healthcare costs.
- Trial name
- NCT06720311
- Testing
- Modified Tubeless Super-Mini Percutaneous Nephrolithotomy, Flexible Ureterorenoscopy, Shockwave Lithotripsy
- Volunteers
- 90 people
- Sponsor
- Assiut University
Hyponatremia, Ascites
Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
The purpose of the study is to investigate the efficacy and safety for the management of hyponatremia and ascites in patients with liver cirrhosis.
- Trial name
- TONIC (NCT01716611)
- Testing
- Tolvaptan
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Konkuk University Medical Center
Obstetric Labor Complications, Vacuum Extraction; Failure, Affecting Fetus or Newborn
Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery
Randomized Control Trial for Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery.
- Conditions
- Obstetric Labor Complications, Vacuum Extraction; Failure, Affecting Fetus or Newborn, Complicated Labour/Delivery Livebirth
- Trial name
- NCT04888871
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Acute Kidney Injury, Acute Renal Failure
Prevention of Intradialytic Hypotension in Acute Kidney Injury Patients
Intradialytic hypotension (IH) is a major complication during acute hemodialysis. The aim of this study was to evaluate the effects of dialysate temperature (DT) reduction with Na and ultrafiltration (UF) profiling on…
- Trial name
- NCT00971971
- Testing
- Dialysis, Standard SLED
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Perinatal Mental Health, Reproductive Behavior
Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine
The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.
- Conditions
- Perinatal Mental Health, Reproductive Behavior, Women, Cohort Studies
- Trial name
- NCT07551934
- Testing
- Psychological Assessment, Routine Clinical Data Collection
- Where
- Ukraine
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Taras Shevchenko National University of Kyiv
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
This phase I clinical trial is studying the side effects and best dose of giving gamma-secretase inhibitor RO4929097 and cediranib maleate together in treating patients with advanced solid tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT01131234
- Testing
- Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Patients With Anorexia Nervosa
Bone Loss in Patients With Anorexia Nervosa
Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term…
- Trial name
- NCT01907464
- Testing
- clinical parameters description, para clinical parameters description, hormonal parameters dosing
- Where
- France
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Recurrent Urinary Tract Infection
Probiotics for Girls With Recurring Urinary Tract Infections
Probiotics are dietary supplements containing potentially beneficial bacterial strains such as Lactobacillus. The safety of oral administration of probiotics has been demonstrated in hundreds of studies using adults over the last…
- Trial name
- NCT00789464
- Testing
- Lactobacillus reuteri DSM 17938, trimethoprim/sulfamethoxazole
- Where
- United States
- Sponsor
- Baylor College of Medicine
Chronic Kidney Disease, Arrhythmia
Defining The Role Of Dialysate Magnesium In Arrhythmogenicity On Dialysis
The study is being performed to better understand dialysis techniques which keep heart functions stable during dialysis. People on dialysis have a high risk for heart disease and strokes.
- Trial name
- NCT00242164
- Testing
- Dialysate Magnesium (Concentration)
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Depression, Anxiety
Treating Common Mental Disorders in Women in Mozambique by Addressing Intimate Partner Violence in Couples
Adapting mental health treatments to address modifiable interpersonal problems has the potential to improve and sustain outcomes in low-resource settings where treatment gaps persist.
- Conditions
- Depression, Anxiety, PTSD, Intimate Partner Violence
- Trial name
- NCT06252909
- Testing
- Interpersonal Psychotherapy for Couples, Interpersonal Psychotherapy (Individual)
- Volunteers
- 108 people
- Sponsor
- New York State Psychiatric Institute
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