Clinical trials: Glaucoma, Open-angle
Glaucoma, Ocular Hypertension
A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)
Evaluate the effectiveness of dorzolamide-timolol (Cosopt®) as first line therapy in reducing intraocular pressure in patients with untreated Open angle glaucoma (OAG) or Ocular hypertension (OH).
- Trial name
- NCT00546286
- Testing
- dorzolamide hydrochloride (+) timolol maleate, Comparator: dorzolamide HCl/timolol maleate + prostaglandin
- Volunteers
- 170 people
- Sponsor
- Merck Sharp & Dohme LLC
Glaucoma, Ocular Hypertension
Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to learn if two different doses of the SpyGlass Bimatoprost-Drug Ring System (BIM-DRS) work to treat adult pseudophakic patients with either glaucoma or ocular hypertension.
- Trial name
- NCT07641296
- Testing
- BIM-DRS Low Dose, BIM-DRS High Dose, SpyGlass IOL with silicone pads (no drug)
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Glaucoma Open-Angle
A Prospective Interventional Cohort Study to Evaluate the Efficacy and Safety of the AquaLumen, a Novel Filtration Procedure for the Treatment of Open Angle Glaucoma
The study will follow a group of patients with glaucoma disease that undergo a surgical procedure intended to reduce the intra-ocular pressure (IOP) for a period of one year.
- Trial name
- NCT06809647
- Testing
- Glaucoma surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- PLU Ophthalmic
Glaucoma, Open Angle Glaucoma
Long-term Safety and Performance of the ARGOS-SC Suprachoroidal Pressure Sensor System in Patients With Glaucoma Underwent Non-penetrating Glaucoma Surgery
The purpose of this study is to evaluate the long-term safety and performance of the ARGOS-SC system.
- Trial name
- NCT04773106
- Testing
- ARGOS-SC suprachoroidal pressure sensor
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 22 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Glaucoma, Inflammatory Response
Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma
The present study's main objective is to assess if there is a significant difference between either of the treatments frequently used in post-op, namely a topic cortisone-based treatment, an non-steroidal anti-inflammatory drug…
- Trial name
- SLT (NCT01058278)
- Testing
- Selective Laser trabeculoplasty
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Open Angle Glaucoma, Ocular Hypertension
Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Pseudoexfoliation Syndrome
- Trial name
- NCT00121147
- Testing
- Travatan, Azopt, Alphagan P
- Where
- 21 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hermann Eye Center
Open-Angle Glaucoma
Collaborative Initial Glaucoma Treatment Study (CIGTS)
To compare the long-term effect of treating newly diagnosed open-angle glaucoma with standard medical treatment versus filtration surgery.
- Trial name
- NCT00000149
- Testing
- Beta Blocker, Trabeculectomy, Argon Laser Trabeculoplasty
- Sponsor
- National Eye Institute (NEI)
Primary Open Angle Glaucoma
Structure Function Correlation in Primary Open Angle Glaucoma
Glaucoma is an optic neuropathy characterised by progressive degeneration of retinal ganglion cells and axons that leads to nerve fibre loss, optic disc cupping, and consecutive glaucomatous visual field defects.
- Trial name
- STR_FN (NCT02028572)
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Vasan Eye Care Hospital
Glaucoma
A Clinical Study Comparing the Inflammatory Response of the Ex-Press Mini Shunt to Trabeculectomy
The less invasive nature of the Ex-Press Mini shunt with mitomycin C induces less post-operative inflammation than trabeculectomy with mitomycin c.
- Trial name
- Optonol (NCT00597181)
- Testing
- Trabeculectomy with mitomycin c, Ex-Press mini shunt with mitomycin c
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Glaucoma, Open-Angle
A Prospective Evaluation of Glaucoma Subjects Treated With Two Second Generation iStents and One iStent Supra
Prospective Evaluation of Open-Angle Glaucoma Subjects treated with two second generation iStents and one iStent Supra
- Trial name
- GCF-041 (NCT03255798)
- Testing
- G2 and G3
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Glaukos Corporation
Primary Open-angle Glaucoma
Impact of Glaucoma and Visual Field Loss on Life Space
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT03673644
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Alabama at Birmingham
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular Hypertension
This study will evaluate the safety and efficacy of new ophthalmic formulations of bimatoprost in patients with open angle glaucoma and ocular hypertension.
- Trial name
- NCT01157364
- Testing
- bimatoprost 20 µg generation 2, bimatoprost 15 µg generation 2, bimatoprost 10 µg generation 2
- Where
- 57 sites in United States, Australia and 8 more
- Volunteers
- 109 people
- Sponsor
- Allergan
GLAUCOMA 1, OPEN ANGLE, D (Disorder), Cataract
Comparison of Visual Outcomes and Patient Satisfaction in Mild to Moderate Glaucoma Patients Undergoing Cataract Surgery With EDOF Versus Monofocal IOLs
Cataract is the leading cause of reversible vision loss, while glaucoma remains the primary cause of irreversible blindness, often impairing contrast sensitivity (CS), glare tolerance, and dark adaptation.
- Trial name
- NCT07436871
- Testing
- Cataract surgery (Monofocal intraocular lens implantation), cataract surgery (Extended depht of focus intraocular lens implantation)
- Volunteers
- 74 people
- Sponsor
- OMIQ Research
Glaucoma, Open-Angle, Glaucoma
Exercise Intervention in Primary Open-angle Glaucoma
EYE-FIT is a randomized clinical trial with a two-arm parallel design aimed at assessing the impact of performing a structured and supervised physical training program on the different variables associated with glaucoma…
- Trial name
- EYE-FIT (NCT05704777)
- Testing
- Exercise, Control
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- Universidad de Granada
Open Angle Glaucoma, Eye Diseases
Effect of Repeated Low-Level Red-Light Therapy on Visual Field Damage in Primary Open-angle Glaucoma
The purpose of this study is to investigate the effect of repeated low-level red-light therapy on existing visual field damages in primary open-angle glaucoma patients.
- Trial name
- NCT05309811
- Testing
- RLRL therapy, Routine IOP-lowering medications
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Open-Angle Glaucoma
Early Manifest Glaucoma Trial (EMGT)
The primary purpose is to compare the effect of immediate therapy to lower the intraocular pressure (IOP) versus late or no treatment on the progression of newly detected open-angle glaucoma, as measured by increasing visual…
- Trial name
- NCT00000132
- Testing
- Betaxolol, Argon Laser Trabeculoplasty
- Where
- 2 sites in Sweden
- Sponsor
- National Eye Institute (NEI)
Glaucoma
Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension
Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults with Primary Open Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT07168902
- Testing
- BL1107 Low dose, BL1107 High dose, Timolol maleate 0.5%
- Where
- 14 sites in United States
- Volunteers
- 252 people
- Sponsor
- Bausch & Lomb Incorporated
Glaucoma, Ocular Hypertension (OH)
A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
The purpose of this study is to evaluate the efficacy, safety and duration of the L-PPDS (latanoprost punctal plug delivery system) at different dose levels.
- Trial name
- NCT01481051
- Testing
- Latanoprost-PPDS
- Where
- 6 sites in United States
- Volunteers
- 57 people
- Sponsor
- Mati Therapeutics Inc.
Glaucoma, Glaucoma, Open Angle
AqueSys XEN 45 Glaucoma Implant in Refractory Glaucoma
To establish the safety and performance of the AqueSys XEN 45 Glaucoma Implant in eyes with refractory glaucoma.
- Trial name
- NCT02036541
- Testing
- AqueSys XEN 45 Glaucoma Implant
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- AqueSys, Inc.
Open-angle Glaucoma, Ocular Hypertension
A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension
The purpose of this study is to assess patient compliance with DuoTrav versus concomitant administration of Timolol 0.5% plus TRAVATAN in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00465803
- Testing
- Travoprost 0.004%/timolol 0.5% ophthalmic solution, Travoprost ophthalmic solution, 0.004%, Timolol maleate ophthalmic solution, 0.5%
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Alcon Research