Clinical trials: Glaucoma; Drugs
Glaucoma, Neovascular
Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied
The researchers in this trial want to learn how the drug aflibercept works in in Japanese patients with increased eye pressure that is caused by new blood vessels growing in the eye (neovascular glaucoma or NVG).
- Trial name
- VENERA (NCT03639675)
- Testing
- Aflibercept (EYLEA, BAY86-5321), Topical IOP-lowering drugs
- Where
- 7 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Bayer
Glaucoma
Clinical Evaluation of Efficacy of SLT to Topical Medication in Lowering IOP
The purpose of this study is to compare Selective laser trabeculoplasty (SLT) and topical medications for initial treatment of open-angle glaucoma /Ocular Hypertension based on intraocular pressure reduction, treatment side…
- Trial name
- NCT01639807
- Testing
- Latanoprost, SLT
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Aurolab
Normal Tension Glaucoma (NTG), Glaucoma
DSLT in Normal Tension Glaucoma (NTG) Asian Eyes
The goal of this clinical trial is to evaluate the efficacy of direct selective laser trabeculoplasty (DSLT) or laser treatment in Asian patients with normal tension glaucoma.
- Conditions
- Normal Tension Glaucoma (NTG), Glaucoma, Open Angle Glaucoma (OAG), Glaucoma, Open Angle
- Trial name
- NCT07300852
- Testing
- Direct Selective Laser Trabeculoplasty (DSLT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ngoc Nguyen Inc.
Compliance
Compliance With Once Daily Glaucoma Medication
A study to examine patient compliance with once daily glaucoma medication
- Trial name
- NCT00333463
- Testing
- Intervention
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Alcon Research
Glaucoma
Visual Function Changes After Intraocular Pressure Reduction
During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure…
- Trial name
- NCT00435058
- Testing
- timolol maleate 0,5%, brimonidine tartrate 0,2%, travoprost 0,004%
- Volunteers
- 54 people
- Sponsor
- University of Sao Paulo
Glaucoma
Improve Glaucoma Medication Adherence
The proposed study is a randomized controlled trial enrolling Veterans with medically treated glaucoma who report less than 100% adherence to the prescribed glaucoma therapy.
- Trial name
- MAGIC (NCT03052257)
- Testing
- Educational - glaucoma, Dose monitoring and reminder, Educational - general
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Dry Eye Disease (DED), Glaucoma
Blinking Exercise Study
The goal of this clinical trial is to evaluate whether a structured blinking exercise can improve symptoms and signs of dry eye disease (DED) in adults with glaucoma who are using topical intraocular pressure-lowering…
- Trial name
- NCT07554937
- Testing
- Structured Blinking Exercise Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Drug Effect (Glaucoma Drugs)
Pupillary Response After Glaucoma Medication
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
- Trial name
- pupil (NCT02522039)
- Testing
- Latanoprost, Timolol, Dorzolamide
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Glaucoma
Success of Transitioning Uncontrolled Glaucoma Patients From Prior Mono or Adjunctive Therapy to DuoTrav
The purpose of this study is to assess the safety and efficacy of transitioning uncontrolled glaucoma patients to DuoTrav from other mono or adjunctive therapies.
- Trial name
- NCT00519753
- Testing
- Travoprost 0.004%/timolol maleate 0.5% fixed combination ophthalmic solution (DuoTrav)
- Where
- Germany
- Volunteers
- 522 people
- Sponsor
- Alcon Research
Glaucoma Medication Adherence
The Impact of a Brief Educational Intervention on Glaucoma Adherence
OBJECTIVE Our objective was to determine whether two group educational sessions plus one-on-one eye drop instillation training would improve adherence to glaucoma therapy as measured by pharmacy claims data in a cohort of newly…
- Trial name
- NCT02097979
- Testing
- Glaucoma Educational Intervention
- Where
- Canada
- Sponsor
- Maisonneuve-Rosemont Hospital
Glaucoma, Ocular Hypertension
Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to learn if two different doses of the SpyGlass Bimatoprost-Drug Ring System (BIM-DRS) work to treat adult pseudophakic patients with either glaucoma or ocular hypertension.
- Trial name
- NCT07641296
- Testing
- BIM-DRS Low Dose, BIM-DRS High Dose, SpyGlass IOL with silicone pads (no drug)
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Glaucoma, Hypertension
Efficiency of XAL-EASE Device in Glaucoma and/or Ocular Hypertension (OHT) Patients, Treated With Xalatan or Xalacom
Xal-Ease is a novel Pfizer-Pharmacia device aimed to significantly facilitate the Xalatan/Xalacom instillation and to avoid loss of Xalatan/Xalacom eye drops due to incorrect instillation.
- Trial name
- NCT01125306
- Testing
- Xal-Ease
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Open Angle Glaucoma, Ocular Hypertension
MINIject Global Long-Term Follow-up Study
The study will assess the long-term (up to 5 years) safety and performance in patients with open-angle glaucoma uncontrolled by topical hypotensive medications who had previously been implanted with a MINIject glaucoma implant.
- Trial name
- STAR-GLOBAL (NCT04524416)
- Testing
- Minimally invasive glaucoma surgery (MIGS)
- Where
- 9 sites in Colombia, France and 4 more
- Volunteers
- 116 people
- Sponsor
- iSTAR Medical
Age-Related Macular Degeneration
The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma
The goal of this clinical trial is to learn if education about additional task lighting, enhanced contrast, enlarged print instructions, smart apps and organizational strategies will improve medication management skills.
- Trial name
- NCT06593405
- Testing
- occupational therapy interventions for low vision care
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- MCPHS University
Glaucoma, Ocular Hypertension
Survey of Patients Taking IOP-Lowering Eye Drops
Survey to assess perspectives of patients prescribed IOP-lowering eye drops at a single office visit.
- Trial name
- NCT02384772
- Testing
- Survey
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- ForSight Vision5, Inc.
Glaucoma, Open-Angle, Glaucoma Eye
MINIject Glaucoma Implant in European Patients
The study will evaluate the efficacy and safety of the MINIject glaucoma implant and Intraocular Pressure (IOP) lowering effects with or without glaucoma medications. The procedure will be a stand-alone surgery.
- Conditions
- Glaucoma, Open-Angle, Glaucoma Eye, Intraocular Pressure
- Trial name
- STAR-II (NCT03624361)
- Testing
- Glaucoma device implantation in a stand-alone procedure
- Where
- 8 sites in France, Germany and 1 more
- Volunteers
- 29 people
- Sponsor
- iSTAR Medical
Glaucoma, Narrow Angle
Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs
The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0.1% vs. 0.2% after laser peripheral iridotomy (LPI).
- Trial name
- NCT01417858
- Testing
- YAG laser peripheral iridotomy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal do Paraná
Hypertension
The Effect of Antihypertensive Medication Timing on Morbidity and Mortality
High blood pressure is common and its presence increases the risk of cardiovascular mortality and morbidity (most notably stroke, myocardial infarction, and congestive heart failure).
- Trial name
- NCT02990663
- Testing
- Use of blood pressure lowering medication at bedtime, Use of blood pressure lowering medication in the morning
- Where
- 5 sites in Canada
- Volunteers
- 3,357 people
- Sponsor
- University of Alberta
Glaucoma, Ocular Hypertension
Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED)
This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
- Trial name
- NCT00108017
- Testing
- MK0507A, dorzolamide hydrochloride (+) timolol maleate, Comparator: timolol maleate, Duration of Treatment: Part 1) 6 wk timolol maleate run in
- Volunteers
- 330 people
- Sponsor
- Merck Sharp & Dohme LLC
Open Angle Glaucoma, Ocular Hypertension
Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT
This clinical trial, led by Dr. Enitan A. Sogbesan at the Hamilton Regional Eye Clinic, St. Joseph's Healthcare Hamilton, aims to compare the efficacy and safety of non-steroidal anti-inflammatory drug (NSAID) ketorolac alone…
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Postoperative Inflammation
- Trial name
- CES-NSLT (NCT06498440)
- Testing
- Ketorolac 0.5% Eye Drops, Ketorolac 0.5% and Fluorometholone 0.1% Eye Drops
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- St. Joseph's Healthcare Hamilton